Methotrexate and Bone formation decreased - a phase IV clinical study of FDA data


Bone formation decreased is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years.

The phase IV clinical study analyzes which people take Methotrexate and have Bone formation decreased. It is created by eHealthMe based on reports of 517,446 people who have side effects when taking Methotrexate from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 07, 2023

517,446 people reported to have side effects when taking Methotrexate.
Among them, 12 people (0.0%) have Bone formation decreased.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 521,855 Methotrexate users for its effectiveness, alternative drugs and more.

What is Bone formation decreased?

Bone formation decreased is found to be associated with 125 drugs and 55 conditions by eHealthMe.

Number of Methotrexate and Bone formation decreased reports submitted per year:

Could Methotrexate cause Bone formation decreased?

Time on Methotrexate when people have Bone formation decreased *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 100 %
  • 10+ years: 0.0 %

Gender of people who have Bone formation decreased when taking Methotrexate *:

  • female: 91.67 %
  • male: 8.33 %

Age of people who have Bone formation decreased when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 27.27 %
  • 50-59: 0.0 %
  • 60+: 72.73 %

Common drugs people take besides Methotrexate *:

  1. Omeprazole: 8 people, 66.67%
  2. Prednisone: 5 people, 41.67%
  3. Penicillamine: 4 people, 33.33%
  4. Humira: 3 people, 25.00%
  5. Ketoprofen: 3 people, 25.00%
  6. Alendronic Acid: 3 people, 25.00%
  7. Atenolol: 3 people, 25.00%
  8. Calcium: 3 people, 25.00%
  9. Captopril: 3 people, 25.00%
  10. Diclofenac Sodium: 3 people, 25.00%

Common side effects people have besides Bone formation decreased *:

  1. Femur Fracture: 8 people, 66.67%
  2. Resorption Bone Increased: 4 people, 33.33%
  3. Broken Bone: 3 people, 25.00%
  4. Oedema Peripheral (superficial swelling): 3 people, 25.00%
  5. Joint Swelling: 3 people, 25.00%
  6. Joint Pain: 3 people, 25.00%
  7. Fracture Delayed Union (delayed cure of broken bone): 3 people, 25.00%
  8. Vitamin D Abnormal: 2 people, 16.67%
  9. Drug Intolerance (drug sensitivity): 2 people, 16.67%
  10. Dysstasia (difficulty in standing): 2 people, 16.67%

Common conditions people have *:

  1. Bone Density Decreased: 4 people, 33.33%
  2. Insomnia (sleeplessness): 3 people, 25.00%
  3. High Blood Pressure: 3 people, 25.00%
  4. Gastric Disorder (disease of stomach): 3 people, 25.00%
  5. Depression: 3 people, 25.00%
  6. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 8.33%
  7. Herpes Virus Infection: 1 person, 8.33%
  8. Bone Loss: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Bone formation decreased?

Check whether Bone formation decreased is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Bone formation decreased and when was it recovered:

Expand to all the drugs that have ingredients of methotrexate sodium:

Alternative drugs to, pros and cons of Methotrexate:

Common Methotrexate side effects:

Browse all side effects of Methotrexate:

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Bone formation decreased treatments and more:

COVID vaccines that are related to Bone formation decreased:

All the drugs that are associated with Bone formation decreased:

All the conditions that are associated with Bone formation decreased:

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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