Who have Diarrhoea with Methotrexate - from FDA reports


Diarrhoea is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Humira, and have Psoriatic arthropathy. This study is created by eHealthMe based on reports of 289,603 people who have side effects when taking Methotrexate from FDA, and is updated regularly.

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On Nov, 14, 2018

289,603 people reported to have side effects when taking Methotrexate.
Among them, 8,822 people (3.05%) have Diarrhoea


Number of reports submitted per year:

Could Methotrexate cause Diarrhoea?

Time on Methotrexate when people have Diarrhoea *:

  • < 1 month: 38.25 %
  • 1 - 6 months: 18.03 %
  • 6 - 12 months: 9.07 %
  • 1 - 2 years: 9.51 %
  • 2 - 5 years: 11.69 %
  • 5 - 10 years: 8.85 %
  • 10+ years: 4.59 %

Gender of people who have Diarrhoea when taking Methotrexate *:

  • female: 74.49 %
  • male: 25.51 %

Age of people who have Diarrhoea when taking Methotrexate *:

  • 0-1: 0.99 %
  • 2-9: 4.06 %
  • 10-19: 5.72 %
  • 20-29: 3.57 %
  • 30-39: 6.94 %
  • 40-49: 13.23 %
  • 50-59: 26.29 %
  • 60+: 39.19 %

Top conditions involved for these people *:

  1. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 729 people, 8.26%
  2. Pain: 524 people, 5.94%
  3. High Blood Pressure: 500 people, 5.67%
  4. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 462 people, 5.24%
  5. Psoriasis (immune-mediated disease that affects the skin): 425 people, 4.82%

Click here to view more results or personalize the results to your gender and age

Top co-used drugs for these people *:

  1. Humira: 1,936 people, 21.95%
  2. Enbrel: 1,919 people, 21.75%
  3. Folic Acid: 1,146 people, 12.99%
  4. Plaquenil: 815 people, 9.24%
  5. Arava: 781 people, 8.85%

Click here to view more results or personalize the results to your gender and age

Top other side effects for these people *:

  1. Nausea (feeling of having an urge to vomit): 2,414 people, 27.36%
  2. Nausea And Vomiting: 2,115 people, 23.97%
  3. Fatigue (feeling of tiredness): 1,352 people, 15.33%
  4. Drug Ineffective: 1,256 people, 14.24%
  5. Abdominal Pain: 1,245 people, 14.11%

Click here to view more results or personalize the results to your gender and age

* Approximation only. Some reports may have incomplete information.

FDA reports used in this study



Do you have Diarrhoea while taking Methotrexate?


You are not alone:




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Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 293,222 users)

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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