Methotrexate and Dna antibody positive - a phase IV clinical study of FDA data

Summary:

Dna antibody positive is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Methotrexate and have Dna antibody positive. It is created by eHealthMe based on reports of 517,446 people who have side effects when taking Methotrexate from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.



On Nov, 24, 2022

517,446 people reported to have side effects when taking Methotrexate.
Among them, 48 people (0.01%) have Dna antibody positive.


What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 521,798 Methotrexate users for its effectiveness, alternative drugs and more.

What is Dna antibody positive?

Dna antibody positive is found to be associated with 235 drugs and 163 conditions by eHealthMe.

Number of Methotrexate and Dna antibody positive reports submitted per year:

Could Methotrexate cause Dna antibody positive?

Time on Methotrexate when people have Dna antibody positive *:

  • < 1 month: 33.33 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 33.33 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 33.33 %
  • 10+ years: 0.0 %

Gender of people who have Dna antibody positive when taking Methotrexate *:

  • female: 86.05 %
  • male: 13.95 %

Age of people who have Dna antibody positive when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 2.94 %
  • 20-29: 2.94 %
  • 30-39: 23.53 %
  • 40-49: 23.53 %
  • 50-59: 23.53 %
  • 60+: 23.53 %

Common drugs people take besides Methotrexate *:

  1. Remicade: 23 people, 47.92%
  2. Folic Acid: 10 people, 20.83%
  3. Enbrel: 8 people, 16.67%
  4. Humira: 7 people, 14.58%
  5. Prednisone: 6 people, 12.50%
  6. Omeprazole: 5 people, 10.42%
  7. Prednisolone: 4 people, 8.33%
  8. Ketoprofen: 4 people, 8.33%
  9. Celebrex: 3 people, 6.25%
  10. Voltaren: 3 people, 6.25%

Common side effects people have besides Dna antibody positive *:

  1. Antinuclear Antibody Positive: 21 people, 43.75%
  2. Lupus-Like Syndrome (a disease symptom matches with lupus an immune disease): 13 people, 27.08%
  3. Rashes (redness): 9 people, 18.75%
  4. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 7 people, 14.58%
  5. Pain: 6 people, 12.50%
  6. Fever: 6 people, 12.50%
  7. Drug Ineffective: 5 people, 10.42%
  8. Pericarditis (inflammation of the pericardium): 5 people, 10.42%
  9. Pericardial Effusion (fluid around the heart): 5 people, 10.42%
  10. Joint Pain: 5 people, 10.42%

Common conditions people have *:

  1. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 8.33%
  2. Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 6.25%
  3. Pustular Psoriasis (raised bumps on the skin that are filled with pus): 2 people, 4.17%
  4. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 2.08%
  5. Reflux Oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus): 1 person, 2.08%
  6. Psoriasis (immune-mediated disease that affects the skin): 1 person, 2.08%
  7. Liver Disorder (liver diseases): 1 person, 2.08%
  8. Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 1 person, 2.08%
  9. High Blood Cholesterol: 1 person, 2.08%
  10. Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 2.08%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Dna antibody positive?

Check whether Dna antibody positive is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.



Related publications that referenced our studies

Related studies

How severe was Dna antibody positive and when was it recovered:

Expand to all the drugs that have ingredients of methotrexate sodium:

Alternative drugs to, pros and cons of Methotrexate:

Common Methotrexate side effects:

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Dna antibody positive treatments and more:

COVID vaccines that are related to Dna antibody positive:

All the drugs that are associated with Dna antibody positive:

All the conditions that are associated with Dna antibody positive:

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

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DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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