Methotrexate and Drug level increased - a phase IV clinical study of FDA data
We study 566,827 people who have side effects when taking Methotrexate. Drug level increased is found, especially among people who are male, 60+ old, have been taking the drug for < 1 month, also take Inflectra and have Crohn's disease.
The phase IV clinical study analyzes which people take Methotrexate and have Drug level increased. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
566,827 people reported to have side effects when taking Methotrexate.
Among them, 868 people (0.15%) have Drug level increased.
What is Methotrexate?
Methotrexate has active ingredients of methotrexate sodium. It is used in rheumatoid arthritis. Currently, eHealthMe is studying from 571,366 Methotrexate users.
What is Drug level increased?
Drug level increased is found to be associated with 1,506 drugs and 1,096 conditions by eHealthMe. Currently, we are studying 18,176 people who have Drug level increased.
Number of Methotrexate and Drug level increased reports submitted per year:
Time on Methotrexate when people have Drug level increased *:
Gender of people who have Drug level increased when taking Methotrexate*:
Age of people who have Drug level increased when taking Methotrexate *:
Common drugs people take besides Methotrexate *:
Common side effects people have besides Drug level increased *:
Common conditions people have *:
* Approximation only. Some reports may have incomplete information.
Do you take Methotrexate and have Drug level increased?Check whether Drug level increased is associated with a drug or a condition
How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Methotrexate side effects by duration, gender and age:
- Methotrexate side effects (571,366 reports)
Drug level increased treatments and more:
- Drug level increased (18,176 reports)
Common drugs associated with Drug level increased:
- Tacrolimus: 1,419 reports
- Metformin: 1,308 reports
- Prednisone: 1,055 reports
- Clozapine: 882 reports
- Methotrexate: 868 reports
- Amlodipine: 686 reports
- Omeprazole: 659 reports
- Furosemide: 610 reports
- Acetaminophen: 559 reports
- Prednisolone: 555 reports
All the drugs that are associated with Drug level increased:
- Drug level increased (1,506 drugs)
Common conditions associated with Drug level increased:
- High blood pressure: 794 reports
- Depression: 600 reports
- Schizophrenia: 562 reports
- Pain: 505 reports
- Epilepsy: 492 reports
- Type 2 diabetes: 474 reports
- Atrial fibrillation/flutter: 421 reports
- Kidney transplant: 389 reports
- Fever: 345 reports
All the conditions that are associated with Drug level increased:
- Drug level increased (1,096 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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