Methotrexate and Headache - a phase IV clinical study of FDA data
We study 566,827 people who have side effects when taking Methotrexate. Headache is found, especially among people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take Enbrel and have Psoriatic arthropathy.
The phase IV clinical study analyzes which people take Methotrexate and have Headache. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
566,827 people reported to have side effects when taking Methotrexate.
Among them, 28,536 people (5.03%) have Headache.
What is Methotrexate?
Methotrexate has active ingredients of methotrexate sodium. It is used in rheumatoid arthritis. Currently, eHealthMe is studying from 571,355 Methotrexate users.
What is Headache?
Headache (pain in head) is found to be associated with 5,264 drugs and 5,646 conditions by eHealthMe. Currently, we are studying 714,741 people who have Headache.
Number of Methotrexate and Headache reports submitted per year:
Time on Methotrexate when people have Headache *:
Gender of people who have Headache when taking Methotrexate*:
Age of people who have Headache when taking Methotrexate *:
Common drugs people take besides Methotrexate *:
Common side effects people have besides Headache *:
Common conditions people have *:
* Approximation only. Some reports may have incomplete information.
Do you take Methotrexate and have Headache?Check whether Headache is associated with a drug or a condition
How to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related publications that referenced our studies
- Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Methotrexate side effects by duration, gender and age:
- Methotrexate side effects (571,355 reports)
Headache treatments and more:
- Headache (714,741 reports)
Common drugs associated with Headache:
- Prednisone: 34,946 reports
- Methotrexate: 28,536 reports
- Humira: 26,867 reports
- Enbrel: 26,565 reports
- Aspirin: 21,238 reports
- Otezla: 16,774 reports
- Xeljanz: 16,267 reports
- Omeprazole: 15,229 reports
- Ibuprofen: 15,134 reports
- Vitamin d: 14,927 reports
All the drugs that are associated with Headache:
- Headache (5,264 drugs)
Common conditions associated with Headache:
- Multiple sclerosis: 41,461 reports
- Rheumatoid arthritis: 40,932 reports
- High blood pressure: 24,649 reports
- Primary pulmonary hypertension: 21,717 reports
- Psoriasis: 21,398 reports
All the conditions that are associated with Headache:
- Headache (5,646 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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