Methotrexate and Joint swelling - a phase IV clinical study of FDA data

Summary:

Joint swelling is found among people who take Methotrexate, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years.

The phase IV clinical study analyzes which people take Methotrexate and have Joint swelling. It is created by eHealthMe based on reports of 517,446 people who have side effects when taking Methotrexate from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Mar, 16, 2023

517,446 people reported to have side effects when taking Methotrexate.
Among them, 29,058 people (5.62%) have Joint swelling.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 521,868 Methotrexate users for its effectiveness, alternative drugs and more.

What is Joint swelling?

Joint swelling is found to be associated with 3,256 drugs and 2,781 conditions by eHealthMe.

Number of Methotrexate and Joint swelling reports submitted per year:

Could Methotrexate cause Joint swelling?

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Joint swelling?

Check whether Joint swelling is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

Related studies

How severe was Joint swelling and when was it recovered:

Joint swelling in Methotrexate

Expand to all the drugs that have ingredients of methotrexate sodium:

Joint swelling and drugs with ingredients of methotrexate sodium (16,923 reports)

Alternative drugs to, pros and cons of Methotrexate:

Methotrexate (521,868 reports)

Common Methotrexate side effects:

Drug ineffective: 104,668 reports
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints): 52,705 reports
Joint pain: 45,719 reports
Pain: 44,785 reports
Fatigue (feeling of tiredness): 36,266 reports
Rashes (redness): 30,738 reports
Joint swelling: 29,058 reports

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Joint swelling treatments and more:

Joint swelling (118,588 reports)

COVID vaccines that are related to Joint swelling:

Common drugs associated with Joint swelling:

All the drugs that are associated with Joint swelling:

Joint swelling (3,256 drugs)

Common conditions associated with Joint swelling:

All the conditions that are associated with Joint swelling:

Joint swelling (2,781 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.