Methotrexate and Leukaemoid reaction - a phase IV clinical study of FDA data


Leukaemoid reaction is found among people who take Methotrexate, especially for people who are female, 60+ old.

The phase IV clinical study analyzes which people take Methotrexate and have Leukaemoid reaction. It is created by eHealthMe based on reports of 517,446 people who have side effects when taking Methotrexate from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Jan, 31, 2023

517,446 people reported to have side effects when taking Methotrexate.
Among them, 7 people (0.0%) have Leukaemoid reaction.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 521,886 Methotrexate users for its effectiveness, alternative drugs and more.

What is Leukaemoid reaction?

Leukaemoid reaction (elevated white blood cell count, or leukocytosis, that is a physiological response to stress or infection) is found to be associated with 276 drugs and 138 conditions by eHealthMe.

Number of Methotrexate and Leukaemoid reaction reports submitted per year:

Could Methotrexate cause Leukaemoid reaction?

Gender of people who have Leukaemoid reaction when taking Methotrexate *:

  • female: 85.71 %
  • male: 14.29 %

Age of people who have Leukaemoid reaction when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 16.67 %
  • 40-49: 0.0 %
  • 50-59: 16.67 %
  • 60+: 66.67 %

Common drugs people take besides Methotrexate *:

  1. Prednisone: 4 people, 57.14%
  2. Solu-Medrol: 3 people, 42.86%
  3. Pentoxifylline: 2 people, 28.57%
  4. Remicade: 2 people, 28.57%
  5. Folic Acid: 2 people, 28.57%
  6. Zoloft: 1 person, 14.29%
  7. Biaxin: 1 person, 14.29%
  8. Celebrex: 1 person, 14.29%
  9. Diovan: 1 person, 14.29%
  10. Fosamax: 1 person, 14.29%

Common side effects people have besides Leukaemoid reaction *:

  1. T-Cell Lymphoma (a blood cell cancer): 3 people, 42.86%
  2. Weight Increased: 1 person, 14.29%
  3. Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 1 person, 14.29%
  4. Blood Albumin Decreased: 1 person, 14.29%
  5. Bone Marrow Failure: 1 person, 14.29%
  6. Chest Pain: 1 person, 14.29%
  7. Fever: 1 person, 14.29%
  8. Haemoglobin Decreased: 1 person, 14.29%
  9. Liver Function Tests Nos Abnormal: 1 person, 14.29%
  10. Metastases To Peritoneum (cancer spreads to peritoneum): 1 person, 14.29%

Common conditions people have *:

  1. Venous Insufficiency (poor circulation of blood caused by damaged or enlarged veins): 2 people, 28.57%
  2. Purpura (purplish discoloration of the skin): 2 people, 28.57%
  3. Polyneuropathy Chronic (chronic neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 2 people, 28.57%
  4. Osteoporosis (bones weak and more likely to break): 2 people, 28.57%
  5. Hypotension (abnormally low blood pressure): 2 people, 28.57%
  6. Dyslipidaemia (abnormal amount of lipids): 2 people, 28.57%

* Approximation only. Some reports may have incomplete information.

Do you take Methotrexate and have Leukaemoid reaction?

Check whether Leukaemoid reaction is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Leukaemoid reaction and when was it recovered:

Expand to all the drugs that have ingredients of methotrexate sodium:

Alternative drugs to, pros and cons of Methotrexate:

Common Methotrexate side effects:

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Leukaemoid reaction treatments and more:

COVID vaccines that are related to Leukaemoid reaction:

All the drugs that are associated with Leukaemoid reaction:

All the conditions that are associated with Leukaemoid reaction:

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Methotrexate) and Methotrexate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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