Methotrexate and Leukoencephalopathy - from FDA reports


Summary

Leukoencephalopathy is found among people who take Methotrexate, especially for people who are female, 10-19 old , have been taking the drug for < 1 month, also take medication Cytarabine, and have Acute lymphocytic leukemia (all). This review analyzes which people have Leukoencephalopathy with Methotrexate. It is created by eHealthMe based on reports of 231,270 people who have side effects when taking Methotrexate from FDA , and is updated regularly.

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On Oct, 19, 2017

231,270 people reported to have side effects when taking Methotrexate.
Among them, 506 people (0.22%) have Leukoencephalopathy


Number of reports submitted per year:

Could Methotrexate cause Leukoencephalopathy?

Time on Methotrexate when people have Leukoencephalopathy *:

  • < 1 month: 64.65 %
  • 1 - 6 months: 23.23 %
  • 6 - 12 months: 6.06 %
  • 1 - 2 years: 3.03 %
  • 2 - 5 years: 1.01 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 2.02 %

Gender of people who have Leukoencephalopathy when taking Methotrexate *:

  • female: 60.45 %
  • male: 39.55 %

Age of people who have Leukoencephalopathy when taking Methotrexate *:

  • 0-1: 0.49 %
  • 2-9: 20.34 %
  • 10-19: 38.24 %
  • 20-29: 2.7 %
  • 30-39: 5.88 %
  • 40-49: 5.15 %
  • 50-59: 11.52 %
  • 60+: 15.69 %

Top conditions involved for these people *:

  • Acute Lymphocytic Leukemia (all) (140 people, 27.67%)
  • Non-Hodgkin's Lymphoma (26 people, 5.14%)
  • Central Nervous System Lymphoma (20 people, 3.95%)
  • Preventive Health Care (18 people, 3.56%)
  • Lymphoma (17 people, 3.36%)

Top co-used drugs for these people *:

  • Cytarabine (146 people, 28.85%)
  • Cyclophosphamide (84 people, 16.60%)
  • Etoposide (73 people, 14.43%)
  • Prednisone (48 people, 9.49%)
  • Mercaptopurine (44 people, 8.70%)

Top other side effects for these people *:

  • Speech Impairment (adult) (62 people, 12.25%)
  • Weakness (52 people, 10.28%)
  • Neurotoxicity (47 people, 9.29%)
  • Headache (37 people, 7.31%)
  • Convulsion (36 people, 7.11%)

* Approximation only. Some reports may have incomplete information.

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Do you have Leukoencephalopathy when taking Methotrexate?

Expand the study to include all drugs with the same ingredients

Leukoencephalopathy and drugs with ingredients of methotrexate sodium.

Expand the study to include reports from both FDA and eHealthMe

Leukoencephalopathy and Methotrexate from FDA and eHealthMe reports

Methotrexate

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 234,881 users)

Leukoencephalopathy

Leukoencephalopathy (disease of the white matter in the brain) has been reported by people with acute lymphocytic leukemia (all), rheumatoid arthritis, high blood pressure, multiple myeloma, pain (latest reports from 2,596 Leukoencephalopathy patients).

Browse all side effects of Methotrexate

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Drugs that are associated with Leukoencephalopathy

Leukoencephalopathy

Could your condition cause Leukoencephalopathy

Leukoencephalopathy

Related studies

What would happen?

Forecast new side effects and undetected conditions when you take Methotrexate and have Leukoencephalopathy.

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