Methotrexate and Lymphedema - from FDA reports


Lymphedema is found among people who take Methotrexate, especially for people who are female, 50-59 old also take medication Arava, . This review analyzes which people have Lymphedema with Methotrexate. It is created by eHealthMe based on reports of 231,270 people who have side effects when taking Methotrexate from FDA , and is updated regularly.

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If you take Methotrexate and have Lymphedema, find out what symptoms you could have in 1 year or longer.

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On Dec, 22, 2017

231,270 people reported to have side effects when taking Methotrexate.
Among them, 8 people (0.0%) have Lymphedema

Number of reports submitted per year:

Could Methotrexate cause Lymphedema?

Gender of people who have Lymphedema when taking Methotrexate *:

  • female: 87.5 %
  • male: 12.5 %

Age of people who have Lymphedema when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 100 %
  • 60+: 0.0 %

Top co-used drugs for these people *:

  • Prednisone (7 people, 87.50%)
  • Ibuprofen (7 people, 87.50%)
  • Arava (7 people, 87.50%)
  • Hydrochlorothiazide (5 people, 62.50%)
  • Chloroquine Phosphate (4 people, 50.00%)

Top other side effects for these people *:

  • Pain (7 people, 87.50%)
  • Malaise (7 people, 87.50%)
  • High Blood Pressure (7 people, 87.50%)
  • Dry Throat (7 people, 87.50%)
  • Drug Ineffective (7 people, 87.50%)

* Approximation only. Some reports may have incomplete information.

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Do you have Lymphedema when taking Methotrexate?

Expand the study to include all drugs with the same ingredients

Lymphedema and drugs with ingredients of methotrexate sodium.

Expand the study to include reports from both FDA and eHealthMe

Lymphedema and Methotrexate from FDA and eHealthMe reports


Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. (latest outcomes from Methotrexate 234,881 users)


Lymphedema (a condition of localized fluid retention and tissue swelling of lymph node) has been reported by people with rheumatoid arthritis, deep venous thrombosis, neoplasm malignant, breast cancer, birth control (latest reports from 96 Lymphedema patients).

Browse all side effects of Methotrexate

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Drugs that are associated with Lymphedema


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What would happen?

Forecast new side effects and undetected conditions when you take Methotrexate and have Lymphedema.

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