Who have Pml with Methotrexate - from FDA reports


Pml is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 5 - 10 years, also take medication Prednisone, and have Systemic lupus erythematosus. This study is created by eHealthMe based on reports of 304,233 people who have side effects when taking Methotrexate from FDA, and is updated regularly.

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On Jan, 17, 2019

304,233 people reported to have side effects when taking Methotrexate.
Among them, 436 people (0.14%) have Pml


Number of reports submitted per year:

Could Methotrexate cause Pml?

Time on Methotrexate when people have Pml *:

  • < 1 month: 9.52 %
  • 1 - 6 months: 26.98 %
  • 6 - 12 months: 15.87 %
  • 1 - 2 years: 1.59 %
  • 2 - 5 years: 14.29 %
  • 5 - 10 years: 28.57 %
  • 10+ years: 3.17 %

Gender of people who have Pml when taking Methotrexate *:

  • female: 63.42 %
  • male: 36.58 %

Age of people who have Pml when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 0.52 %
  • 10-19: 5.25 %
  • 20-29: 3.94 %
  • 30-39: 4.99 %
  • 40-49: 14.17 %
  • 50-59: 24.67 %
  • 60+: 46.46 %

Top conditions involved for these people *:

  1. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 27 people, 6.19%
  2. Tonsil Cancer: 22 people, 5.05%
  3. Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 18 people, 4.13%
  4. Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 15 people, 3.44%
  5. Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 15 people, 3.44%
  6. Osteoporosis (bones weak and more likely to break): 14 people, 3.21%
  7. Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 14 people, 3.21%
  8. Hepatitis B: 14 people, 3.21%
  9. Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 14 people, 3.21%
  10. High Blood Pressure: 14 people, 3.21%

Top co-used drugs for these people *:

  1. Prednisone: 62 people, 14.22%
  2. Folic Acid: 53 people, 12.16%
  3. Rituxan: 52 people, 11.93%
  4. Cyclophosphamide: 50 people, 11.47%
  5. Prednisolone: 42 people, 9.63%
  6. Remicade: 41 people, 9.40%
  7. Azathioprine: 35 people, 8.03%
  8. Methylprednisolone: 28 people, 6.42%
  9. Humira: 26 people, 5.96%
  10. Nexium: 25 people, 5.73%

Top other side effects for these people *:

  1. Jc Virus Infection: 66 people, 15.14%
  2. Speech Impairment (Adult) (inability to speak (adult)): 35 people, 8.03%
  3. Pneumonia: 23 people, 5.28%
  4. Lymphopenia (an abnormally low level of lymphocytes in the blood): 23 people, 5.28%
  5. Weakness: 22 people, 5.05%
  6. Confusion: 19 people, 4.36%
  7. Drug Ineffective: 18 people, 4.13%
  8. Swallowing Difficulty: 18 people, 4.13%
  9. Fever: 17 people, 3.90%
  10. Dizziness: 16 people, 3.67%

* Approximation only. Some reports may have incomplete information.

Do you have Pml while taking Methotrexate?


You are not alone:




Related studies

Methotrexate

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Pml has been reported by people with multiple sclerosis, relapsing-remitting multiple sclerosis, chronic lymphocytic leukaemia, non-hodgkin's lymphoma, rheumatoid arthritis (latest reports from 9,144 Pml patients).


Drugs that are associated with Pml
Pml (839 drugs)
Could your condition cause Pml
Pml (604 conditions)
Methotrexate side effects

Browse by gender and age

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+


Browse all side effects of Methotrexate
a b c d e f g h i j k l m n o p q r s t u v w x y z

Compare Methotrexate to similar drugs:

Related publications that referenced our studies


What would happen?

Predict new side effects and undetected conditions when you take Methotrexate and have Pml


FDA reports used in this study



Recent updates

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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