Methotrexate and Pml - from FDA reports


Pml is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 5 - 10 years, also take medication Prednisone, and have Systemic lupus erythematosus. This study is created by eHealthMe based on reports of 289,603 people who have side effects when taking Methotrexate from FDA, and is updated regularly.

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On Sep, 11, 2018

289,603 people reported to have side effects when taking Methotrexate.
Among them, 379 people (0.13%) have Pml


Number of reports submitted per year:

Could Methotrexate cause Pml?

Time on Methotrexate when people have Pml *:

Gender of people who have Pml when taking Methotrexate *:

  • female: 64.48 %
  • male: 35.52 %

Age of people who have Pml when taking Methotrexate *:

Top conditions involved for these people *:

  1. Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 27 people, 7.12%
  2. Tonsil Cancer: 22 people, 5.80%
  3. Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 18 people, 4.75%
  4. Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 15 people, 3.96%
  5. Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 15 people, 3.96%

Click here to view more results or personalize the results to your gender and age

Top co-used drugs for these people *:

  1. Prednisone: 62 people, 16.36%
  2. Folic Acid: 53 people, 13.98%
  3. Cyclophosphamide: 50 people, 13.19%
  4. Rituxan: 45 people, 11.87%
  5. Prednisolone: 42 people, 11.08%

Click here to view more results or personalize the results to your gender and age

Top other side effects for these people *:

  1. Jc Virus Infection: 48 people, 12.66%
  2. Speech Impairment (Adult) (inability to speak (adult)): 34 people, 8.97%
  3. Pneumonia: 23 people, 6.07%
  4. Lymphopenia (an abnormally low level of lymphocytes in the blood): 23 people, 6.07%
  5. Weakness: 21 people, 5.54%

Click here to view more results or personalize the results to your gender and age

* Approximation only. Some reports may have incomplete information.

FDA reports used in this study



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Do you have Pml while taking Methotrexate?



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What would happen?

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