Methotrexate and Pml - from FDA reports


Pml is found among people who take Methotrexate, especially for people who are female, 60+ old , have been taking the drug for 5 - 10 years, also take medication Prednisone, and have Tonsil cancer. This review analyzes which people have Pml with Methotrexate. It is created by eHealthMe based on reports of 231,270 people who have side effects when taking Methotrexate from FDA , and is updated regularly.


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On Apr, 06, 2018

231,270 people reported to have side effects when taking Methotrexate.
Among them, 342 people (0.15%) have Pml


Number of reports submitted per year:

Could Methotrexate cause Pml?

Time on Methotrexate when people have Pml *:

  • < 1 month: 9.43 %
  • 1 - 6 months: 22.64 %
  • 6 - 12 months: 18.87 %
  • 1 - 2 years: 1.8900000000000001 %
  • 2 - 5 years: 13.21 %
  • 5 - 10 years: 30.19 %
  • 10+ years: 3.77 %

Gender of people who have Pml when taking Methotrexate *:

  • female: 65.87 %
  • male: 34.13 %

Age of people who have Pml when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 0.67 %
  • 10-19: 6.71 %
  • 20-29: 2.35 %
  • 30-39: 6.38 %
  • 40-49: 18.12 %
  • 50-59: 21.81 %
  • 60+: 43.96 %

Top conditions involved for these people *:

  • Tonsil Cancer: 22 people, 6.43%
  • Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 21 people, 6.14%
  • Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 15 people, 4.39%
  • Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 15 people, 4.39%
  • Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 14 people, 4.09%

Top co-used drugs for these people *:

  • Prednisone: 62 people, 18.13%
  • Folic Acid: 53 people, 15.50%
  • Cyclophosphamide: 50 people, 14.62%
  • Rituxan: 43 people, 12.57%
  • Prednisolone: 42 people, 12.28%

Top other side effects for these people *:

  • Jc Virus Infection: 39 people, 11.40%
  • Speech Impairment (Adult) (inability to speak (adult)): 32 people, 9.36%
  • Pneumonia: 23 people, 6.73%
  • Weakness: 19 people, 5.56%
  • Drug Ineffective: 18 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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Related studies

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Pml has been reported by people with multiple sclerosis, relapsing-remitting multiple sclerosis, chronic lymphocytic leukaemia, non-hodgkin's lymphoma, rheumatoid arthritis (latest reports from 7,860 Pml patients).


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