Who have Tic douloureux with Methotrexate - from FDA reports


Tic douloureux is found among people who take Methotrexate, especially for people who are female, 50-59 old , have been taking the drug for 6 - 12 months, also take medication Enbrel, and have Psoriatic arthropathy. This study is created by eHealthMe based on reports of 304,233 people who have side effects when taking Methotrexate from FDA, and is updated regularly.

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On Jan, 10, 2019

304,233 people reported to have side effects when taking Methotrexate.
Among them, 38 people (0.01%) have Tic douloureux


Number of reports submitted per year:

Could Methotrexate cause Tic douloureux?

Time on Methotrexate when people have Tic douloureux *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 25 %
  • 6 - 12 months: 25 %
  • 1 - 2 years: 25 %
  • 2 - 5 years: 25 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Tic douloureux when taking Methotrexate *:

  • female: 94.59 %
  • male: 5.41 %

Age of people who have Tic douloureux when taking Methotrexate *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 7.41 %
  • 20-29: 0.0 %
  • 30-39: 7.41 %
  • 40-49: 14.81 %
  • 50-59: 40.74 %
  • 60+: 29.63 %

Top conditions involved for these people *:

  1. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 13.16%
  2. Neuralgia (pain in one or more nerves): 3 people, 7.89%
  3. Depression: 3 people, 7.89%
  4. Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 7.89%
  5. High Blood Pressure: 3 people, 7.89%
  6. Psoriasis (immune-mediated disease that affects the skin): 2 people, 5.26%
  7. Pain: 2 people, 5.26%
  8. Migraine (headache): 1 person, 2.63%
  9. Acidosis (build-up of carbon dioxide in the blood): 1 person, 2.63%
  10. Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 1 person, 2.63%

Top co-used drugs for these people *:

  1. Humira: 12 people, 31.58%
  2. Enbrel: 12 people, 31.58%
  3. Folic Acid: 11 people, 28.95%
  4. Orencia: 5 people, 13.16%
  5. Lyrica: 4 people, 10.53%
  6. Remicade: 4 people, 10.53%
  7. Simvastatin: 3 people, 7.89%
  8. Celebrex: 3 people, 7.89%
  9. Trileptal: 3 people, 7.89%
  10. Diovan: 3 people, 7.89%

Top other side effects for these people *:

  1. Herpes Zoster: 5 people, 13.16%
  2. The Flu (the flu is caused by an influenza virus): 5 people, 13.16%
  3. Pain: 5 people, 13.16%
  4. Psoriasis (immune-mediated disease that affects the skin): 4 people, 10.53%
  5. Sinusitis (inflammation of sinus): 4 people, 10.53%
  6. Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 10.53%
  7. Fatigue (feeling of tiredness): 3 people, 7.89%
  8. Hair Loss: 3 people, 7.89%
  9. Joint Pain: 3 people, 7.89%
  10. Foot Deformity (functional disability of foot): 3 people, 7.89%

* Approximation only. Some reports may have incomplete information.

FDA reports used in this study



Do you have Tic douloureux while taking Methotrexate?


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Browse by gender and age

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+


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