Metoclopramide and Monoclonal gammopathy - a phase IV clinical study of FDA data


We study 76,991 people who have side effects when taking Metoclopramide. Monoclonal gammopathy is found, especially among people who are male, 50-59 old, have been taking the drug for 10+ years, also take Albuterol and have Multiple myeloma.

The phase IV clinical study analyzes which people take Metoclopramide and have Monoclonal gammopathy. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 28, 2023

76,991 people reported to have side effects when taking Metoclopramide.
Among them, 12 people (0.02%) have Monoclonal gammopathy.

What is Metoclopramide?

Metoclopramide has active ingredients of metoclopramide hydrochloride. It is used in nausea. Currently, eHealthMe is studying from 77,443 Metoclopramide users.

What is Monoclonal gammopathy?

Monoclonal gammopathy is found to be associated with 477 drugs and 215 conditions by eHealthMe. Currently, we are studying 2,498 people who have Monoclonal gammopathy.

Number of Metoclopramide and Monoclonal gammopathy reports submitted per year:

Could Metoclopramide cause Monoclonal gammopathy?

Time on Metoclopramide when people have Monoclonal gammopathy *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 100 %

Gender of people who have Monoclonal gammopathy when taking Metoclopramide *:

  • female: 50 %
  • male: 50 %

Age of people who have Monoclonal gammopathy when taking Metoclopramide *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 25 %
  • 50-59: 75 %
  • 60+: 0.0 %

Common drugs people take besides Metoclopramide *:

  1. Albuterol: 8 people, 66.67%
  2. Zometa: 7 people, 58.33%
  3. Pepcid: 7 people, 58.33%
  4. Alprazolam: 6 people, 50.00%
  5. Prevacid: 6 people, 50.00%
  6. Lisinopril: 6 people, 50.00%
  7. Lipitor: 6 people, 50.00%
  8. Lexapro: 6 people, 50.00%
  9. Furosemide: 6 people, 50.00%
  10. Celebrex: 6 people, 50.00%

Common side effects people have besides Monoclonal gammopathy *:

  1. Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 8 people, 66.67%
  2. Pain: 8 people, 66.67%
  3. Breathing Difficulty: 8 people, 66.67%
  4. Weight Loss: 7 people, 58.33%
  5. Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 7 people, 58.33%
  6. Neuropathy Peripheral (surface nerve damage): 7 people, 58.33%
  7. Arthritis (form of joint disorder that involves inflammation of one or more joints): 7 people, 58.33%
  8. Thrombocytopenia (decrease of platelets in blood): 7 people, 58.33%
  9. Depression: 7 people, 58.33%
  10. Stress And Anxiety: 6 people, 50.00%

Common conditions people have *:

  1. Multiple Myeloma (cancer of the plasma cells): 5 people, 41.67%
  2. Pain: 3 people, 25.00%
  3. Indigestion: 3 people, 25.00%
  4. Hiv Infection: 3 people, 25.00%
  5. High Blood Cholesterol: 3 people, 25.00%
  6. Depression: 3 people, 25.00%
  7. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 3 people, 25.00%
  8. Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 2 people, 16.67%
  9. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 8.33%
  10. Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Metoclopramide and have Monoclonal gammopathy?

Check whether Monoclonal gammopathy is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Metoclopramide side effects by duration, gender and age:

Monoclonal gammopathy treatments and more:

Common drugs associated with Monoclonal gammopathy:

All the drugs that are associated with Monoclonal gammopathy:

All the conditions that are associated with Monoclonal gammopathy:

How the study uses the data?

The study uses data from the FDA. It is based on metoclopramide hydrochloride (the active ingredients of Metoclopramide) and Metoclopramide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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