Metoclopramide and Sjogren syndrome - a phase IV clinical study of FDA data


We study 76,991 people who have side effects when taking Metoclopramide. Sjogren syndrome is found, especially among people who are female, 60+ old, have been taking the drug for 5 - 10 years, also take Escitalopram and have Pain.

The phase IV clinical study analyzes which people take Metoclopramide and have Sjogren syndrome. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 30, 2023

76,991 people reported to have side effects when taking Metoclopramide.
Among them, 36 people (0.05%) have Sjogren syndrome.

What is Metoclopramide?

Metoclopramide has active ingredients of metoclopramide hydrochloride. It is used in nausea. Currently, eHealthMe is studying from 77,443 Metoclopramide users.

What is Sjogren syndrome?

Sjogren syndrome (a disease that causes dryness in the mouth and eyes) is found to be associated with 1,522 drugs and 921 conditions by eHealthMe. Currently, we are studying 11,583 people who have Sjogren syndrome.

Number of Metoclopramide and Sjogren syndrome reports submitted per year:

Could Metoclopramide cause Sjogren syndrome?

Time on Metoclopramide when people have Sjogren syndrome *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 40 %
  • 2 - 5 years: 20 %
  • 5 - 10 years: 40 %
  • 10+ years: 0.0 %

Gender of people who have Sjogren syndrome when taking Metoclopramide *:

  • female: 87.88 %
  • male: 12.12 %

Age of people who have Sjogren syndrome when taking Metoclopramide *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 10 %
  • 30-39: 10 %
  • 40-49: 10 %
  • 50-59: 0.0 %
  • 60+: 70 %

Common drugs people take besides Metoclopramide *:

  1. Escitalopram: 15 people, 41.67%
  2. Novalgin: 7 people, 19.44%
  3. Xyrem: 5 people, 13.89%
  4. Singulair: 4 people, 11.11%
  5. Valtrex: 4 people, 11.11%
  6. Protonix: 4 people, 11.11%
  7. Promethazine: 4 people, 11.11%
  8. Hydrocodone Bitartrate And Acetaminophen: 4 people, 11.11%
  9. Hydrochlorothiazide: 4 people, 11.11%
  10. Oxycontin: 3 people, 8.33%

Common side effects people have besides Sjogren syndrome *:

  1. Stress And Anxiety: 24 people, 66.67%
  2. Pain: 22 people, 61.11%
  3. Back Pain: 22 people, 61.11%
  4. Headache (pain in head): 20 people, 55.56%
  5. Pain In Extremity: 20 people, 55.56%
  6. Intervertebral Disc Degeneration (spinal disc degeneration): 19 people, 52.78%
  7. Joint Pain: 19 people, 52.78%
  8. Muscle Aches (muscle pain): 19 people, 52.78%
  9. Dizziness: 19 people, 52.78%
  10. Depression: 18 people, 50.00%

Common conditions people have *:

  1. Pain: 19 people, 52.78%
  2. Depression: 16 people, 44.44%
  3. High Blood Pressure: 16 people, 44.44%
  4. Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 15 people, 41.67%
  5. Pneumonia: 15 people, 41.67%
  6. Micturition Urgency (urgency to pass the urine): 15 people, 41.67%
  7. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 15 people, 41.67%
  8. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 13.89%
  9. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 8.33%
  10. Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Metoclopramide and have Sjogren syndrome?

Check whether Sjogren syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Metoclopramide side effects by duration, gender and age:

Sjogren syndrome treatments and more:

Common drugs associated with Sjogren syndrome:

All the drugs that are associated with Sjogren syndrome:

Common conditions associated with Sjogren syndrome:

All the conditions that are associated with Sjogren syndrome:

How the study uses the data?

The study uses data from the FDA. It is based on metoclopramide hydrochloride (the active ingredients of Metoclopramide) and Metoclopramide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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