Metoprolol succinate and Muscle twitching - a phase IV clinical study of FDA data


Muscle twitching is found among people who take Metoprolol succinate, especially for people who are male, 60+ old, have been taking the drug for 6 - 12 months.

The phase IV clinical study analyzes which people take Metoprolol succinate and have Muscle twitching. It is created by eHealthMe based on reports of 47,070 people who have side effects when taking Metoprolol succinate from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On Jul, 04, 2022

47,070 people reported to have side effects when taking Metoprolol succinate.
Among them, 64 people (0.14%) have Muscle twitching.

What is Metoprolol succinate?

Metoprolol succinate has active ingredients of metoprolol succinate. It is often used in high blood pressure. eHealthMe is studying from 49,347 Metoprolol succinate users for its effectiveness, alternative drugs and more.

What is Muscle twitching?

Muscle twitching is found to be associated with 2,291 drugs and 1,753 conditions by eHealthMe.

Number of Metoprolol succinate and Muscle twitching reports submitted per year:

Could Metoprolol succinate cause Muscle twitching?

Time on Metoprolol succinate when people have Muscle twitching *:

  • < 1 month: 16.67 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 66.67 %
  • 1 - 2 years: 16.67 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Muscle twitching when taking Metoprolol succinate *:

  • female: 43.33 %
  • male: 56.67 %

Age of people who have Muscle twitching when taking Metoprolol succinate *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 2.27 %
  • 20-29: 2.27 %
  • 30-39: 0.0 %
  • 40-49: 11.36 %
  • 50-59: 20.45 %
  • 60+: 63.64 %

Common drugs people take besides Metoprolol succinate *:

  1. Xyrem: 8 people, 12.50%
  2. Neurontin: 8 people, 12.50%
  3. Lasix: 7 people, 10.94%
  4. Lipitor: 7 people, 10.94%
  5. Coumadin: 6 people, 9.38%
  6. Clonazepam: 6 people, 9.38%
  7. Xarelto: 6 people, 9.38%
  8. Cymbalta: 6 people, 9.38%
  9. Nitrostat: 5 people, 7.81%
  10. Lisinopril: 5 people, 7.81%

Common side effects people have besides Muscle twitching *:

  1. Fatigue (feeling of tiredness): 18 people, 28.12%
  2. Fall: 16 people, 25.00%
  3. Stress And Anxiety: 16 people, 25.00%
  4. Weakness: 14 people, 21.88%
  5. Pain In Extremity: 14 people, 21.88%
  6. Dizziness: 14 people, 21.88%
  7. Nausea (feeling of having an urge to vomit): 10 people, 15.62%
  8. Weight Decreased: 9 people, 14.06%
  9. Hypoaesthesia (reduced sense of touch or sensation): 9 people, 14.06%
  10. Muscle Spasms (muscle contraction): 9 people, 14.06%

Common conditions people have *:

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 12.50%
  2. Stress And Anxiety: 8 people, 12.50%
  3. Agitation (state of anxiety or nervous excitement): 6 people, 9.38%
  4. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 9.38%
  5. High Blood Cholesterol: 5 people, 7.81%
  6. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 6.25%
  7. Depression: 4 people, 6.25%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 4.69%
  9. Pain In Extremity: 3 people, 4.69%
  10. Muscle Spasms (muscle contraction): 3 people, 4.69%

* Approximation only. Some reports may have incomplete information.

Do you take Metoprolol succinate and have Muscle twitching?

Check whether Muscle twitching is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Alternative drugs to, pros and cons of Metoprolol succinate:

Muscle twitching treatments and more:

COVID vaccines that are related to Muscle twitching:

How severe was Muscle twitching and when was it recovered:

Expand to all the drugs that have ingredients of metoprolol succinate:

Common drugs associated with Muscle twitching:

All the drugs that are associated with Muscle twitching:

Common conditions associated with Muscle twitching:

All the conditions that are associated with Muscle twitching:

How the study uses the data?

The study uses data from the FDA. It is based on metoprolol succinate (the active ingredients of Metoprolol succinate) and Metoprolol succinate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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