Mirena and Melasma - from FDA reports

Melasma is found among people who take Mirena, especially for people who are 40-49 old , have been taking the drug for 2 - 5 years, also take medication Mefenamic Acid, and have Heavy or prolong menstrual bleeding. This review analyzes which people have Melasma with Mirena. It is created by eHealthMe based on reports of 98,847 people who have side effects when taking Mirena from FDA, and is updated regularly.

On Jul, 15, 2018

98,847 people reported to have side effects when taking Mirena.
Among them, 51 people (0.05%) have Melasma

Number of reports submitted per year:

Could Mirena cause Melasma?

Time on Mirena when people have Melasma *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 20 %
  • 1 - 2 years: 30 %
  • 2 - 5 years: 30 %
  • 5 - 10 years: 20 %
  • 10+ years: 0.0 %

Age of people who have Melasma when taking Mirena *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 46.88 %
  • 40-49: 50.0 %
  • 50-59: 3.12 %
  • 60+: 0.0 %

Top conditions involved for these people *:

  1. Heavy Or Prolong Menstrual Bleeding: 12 people, 23.53%
  2. Menstruation Irregular: 1 person, 1.96%
  3. Intra-Uterine Contraceptive Device: 1 person, 1.96%
  4. Asthma: 1 person, 1.96%

Top co-used drugs for these people *:

  1. Mesalamine: 2 people, 3.92%
  2. Mefenamic Acid: 2 people, 3.92%
  3. Spironolactone: 1 person, 1.96%
  4. Plaquenil: 1 person, 1.96%
  5. Paxil: 1 person, 1.96%

Top other side effects for these people *:

  1. Abdominal Distension: 4 people, 7.84%
  2. Depression: 3 people, 5.88%
  3. Amenorrhea (absence of a menstrual period in a woman of reproductive age): 3 people, 5.88%
  4. Weight Increased: 3 people, 5.88%
  5. Hot Flush (sudden feelings of heat): 2 people, 3.92%

* Approximation only. Some reports may have incomplete information.

Experience matters! A new approach to health care:

What's next: manage your medications

Related studies


Mirena has active ingredients of levonorgestrel. It is often used in birth control. (latest outcomes from Mirena 100,169 users)


Melasma (the mask of pregnancy when present in pregnant women) is a tan or dark skin discoloration) has been reported by people with birth control, heavy or prolong menstrual bleeding, hormone replacement therapy, multiple sclerosis, melasma (latest reports from 648 Melasma patients).

Drugs that are associated with Melasma
Melasma (262 drugs)
Could your condition cause Melasma
Melasma (156 conditions)
Mirena side effects
Browse all side effects of Mirena
a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

What would happen?

Predict new side effects and undetected conditions when you take Mirena and have Melasma

You are not alone. Join our personalized support groups:

You may be interested in these posts

More posts for: Mirena, Melasma

Recent updates

General studies
Active Support Groups
Latest posts

NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.