Mitoxantrone and Left ventricular failure - a phase IV clinical study of FDA data


Left ventricular failure is found among people who take Mitoxantrone, especially for people who are female, 20-29 old.

The phase IV clinical study analyzes which people take Mitoxantrone and have Left ventricular failure. It is created by eHealthMe based on reports of 7,190 people who have side effects when taking Mitoxantrone from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Mar, 26, 2023

7,190 people reported to have side effects when taking Mitoxantrone.
Among them, 19 people (0.26%) have Left ventricular failure.

What is Mitoxantrone?

Mitoxantrone has active ingredients of mitoxantrone hydrochloride. eHealthMe is studying from 7,198 Mitoxantrone users for its effectiveness, alternative drugs and more.

What is Left ventricular failure?

Left ventricular failure (left ventricle fails to contract forcefully) is found to be associated with 1,351 drugs and 603 conditions by eHealthMe.

Number of Mitoxantrone and Left ventricular failure reports submitted per year:

Could Mitoxantrone cause Left ventricular failure?

Gender of people who have Left ventricular failure when taking Mitoxantrone *:

  • female: 70.59 %
  • male: 29.41 %

Age of people who have Left ventricular failure when taking Mitoxantrone *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 43.75 %
  • 30-39: 0.0 %
  • 40-49: 31.25 %
  • 50-59: 6.25 %
  • 60+: 18.75 %

Common drugs people take besides Mitoxantrone *:

  1. Herceptin: 2 people, 10.53%
  2. Busulfex: 2 people, 10.53%
  3. Cyclophosphamide: 2 people, 10.53%
  4. Dexamethasone: 2 people, 10.53%
  5. Zevalin: 1 person, 5.26%
  6. Cisplatin: 1 person, 5.26%
  7. Cladribine: 1 person, 5.26%
  8. Cytarabine: 1 person, 5.26%
  9. Etoposide: 1 person, 5.26%
  10. Fluconazole: 1 person, 5.26%

Common side effects people have besides Left ventricular failure *:

  1. Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 5 people, 26.32%
  2. Haematotoxicity (toxins that destroy red blood cells): 5 people, 26.32%
  3. Bradycardia (abnormally slow heart action): 5 people, 26.32%
  4. Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system): 5 people, 26.32%
  5. Hepatotoxicity (chemical-driven liver damage): 4 people, 21.05%
  6. Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 4 people, 21.05%
  7. Infection: 4 people, 21.05%
  8. Febrile Neutropenia (fever with reduced white blood cells): 3 people, 15.79%
  9. Cardiotoxicity (damage to the heart muscle): 3 people, 15.79%
  10. Fever: 2 people, 10.53%

Common conditions people have *:

  1. Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 7 people, 36.84%
  2. Acute Lymphocytic Leukaemia Recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent): 5 people, 26.32%
  3. Refractory Cancer (cancer that has not responded to treatment): 1 person, 5.26%
  4. Follicle Centre Lymphoma, Follicular Grade I, Ii, Iii Stage Iv: 1 person, 5.26%
  5. Bone Marrow Failure: 1 person, 5.26%
  6. Bone Marrow Conditioning Regimen: 1 person, 5.26%
  7. Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Mitoxantrone and have Left ventricular failure?

Check whether Left ventricular failure is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Left ventricular failure and when was it recovered:

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Alternative drugs to, pros and cons of Mitoxantrone:

Common Mitoxantrone side effects:

Browse all side effects of Mitoxantrone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Left ventricular failure treatments and more:

COVID vaccines that are related to Left ventricular failure:

Common drugs associated with Left ventricular failure:

All the drugs that are associated with Left ventricular failure:

Common conditions associated with Left ventricular failure:

All the conditions that are associated with Left ventricular failure:

How the study uses the data?

The study uses data from the FDA. It is based on mitoxantrone hydrochloride (the active ingredients of Mitoxantrone) and Mitoxantrone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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