Naprosyn and Cardiac valve disease - a phase IV clinical study of FDA data


Cardiac valve disease is found among people who take Naprosyn, especially for people who are female, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Naprosyn and have Cardiac valve disease. It is created by eHealthMe based on reports of 15,552 people who have side effects when taking Naprosyn from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Jan, 24, 2023

15,552 people reported to have side effects when taking Naprosyn.
Among them, 20 people (0.13%) have Cardiac valve disease.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 15,944 Naprosyn users for its effectiveness, alternative drugs and more.

What is Cardiac valve disease?

Cardiac valve disease (heart valve disease) is found to be associated with 1,286 drugs and 706 conditions by eHealthMe.

Number of Naprosyn and Cardiac valve disease reports submitted per year:

Could Naprosyn cause Cardiac valve disease?

Time on Naprosyn when people have Cardiac valve disease *:

  • < 1 month: 50 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 50 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Cardiac valve disease when taking Naprosyn *:

  • female: 65 %
  • male: 35 %

Age of people who have Cardiac valve disease when taking Naprosyn *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 37.5 %
  • 40-49: 0.0 %
  • 50-59: 12.5 %
  • 60+: 50.0 %

Common drugs people take besides Naprosyn *:

  1. Tylenol: 7 people, 35.00%
  2. Diflucan: 6 people, 30.00%
  3. Allopurinol: 6 people, 30.00%
  4. Prilosec: 6 people, 30.00%
  5. Ondansetron: 5 people, 25.00%
  6. Novolin R: 5 people, 25.00%
  7. Mirtazapine: 5 people, 25.00%
  8. Metoprolol Tartrate: 5 people, 25.00%
  9. Methotrexate: 5 people, 25.00%
  10. Lantus: 5 people, 25.00%

Common side effects people have besides Cardiac valve disease *:

  1. Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 7 people, 35.00%
  2. Breathing Difficulty: 7 people, 35.00%
  3. Depression: 6 people, 30.00%
  4. Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 6 people, 30.00%
  5. Oedema Peripheral (superficial swelling): 6 people, 30.00%
  6. Hypotension (abnormally low blood pressure): 5 people, 25.00%
  7. Hypocalcaemia (levels of calcium in blood serum are abnormally low): 5 people, 25.00%
  8. Hypoalbuminaemia (levels of albumin in blood serum are abnormally low): 5 people, 25.00%
  9. Hyperhidrosis (abnormally increased sweating): 5 people, 25.00%
  10. Hyperglycemia (high blood sugar): 5 people, 25.00%

Common conditions people have *:

  1. Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 5 people, 25.00%
  2. Tumor Lysis Syndrome: 5 people, 25.00%
  3. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 25.00%
  4. Stress And Anxiety: 3 people, 15.00%
  5. Breathing Difficulty: 2 people, 10.00%
  6. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 10.00%
  7. Gastric Disorder (disease of stomach): 2 people, 10.00%
  8. High Blood Pressure: 2 people, 10.00%
  9. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 10.00%
  10. Iron Deficiency Anaemia: 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Naprosyn and have Cardiac valve disease?

Check whether Cardiac valve disease is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Cardiac valve disease and when was it recovered:

Expand to all the drugs that have ingredients of naproxen:

Alternative drugs to, pros and cons of Naprosyn:

Common Naprosyn side effects:

Browse all side effects of Naprosyn:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Cardiac valve disease treatments and more:

COVID vaccines that are related to Cardiac valve disease:

Common drugs associated with Cardiac valve disease:

All the drugs that are associated with Cardiac valve disease:

Common conditions associated with Cardiac valve disease:

All the conditions that are associated with Cardiac valve disease:

How the study uses the data?

The study uses data from the FDA. It is based on naproxen (the active ingredients of Naprosyn) and Naprosyn (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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