Nexium 24hr and Hypertonic bladder - a phase IV clinical study of FDA data


Hypertonic bladder is found among people who take Nexium 24hr, especially for people who are female, 40-49 old, have been taking the drug for 10+ years.

The phase IV clinical study analyzes which people take Nexium 24hr and have Hypertonic bladder. It is created by eHealthMe based on reports of 44,164 people who have side effects when taking Nexium 24hr from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 18, 2023

44,164 people reported to have side effects when taking Nexium 24hr.
Among them, 6 people (0.01%) have Hypertonic bladder.

What is Nexium 24hr?

Nexium 24hr has active ingredients of esomeprazole magnesium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 44,325 Nexium 24hr users for its effectiveness, alternative drugs and more.

What is Hypertonic bladder?

Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate) is found to be associated with 1,099 drugs and 491 conditions by eHealthMe.

Number of Nexium 24hr and Hypertonic bladder reports submitted per year:

Could Nexium 24hr cause Hypertonic bladder?

Time on Nexium 24hr when people have Hypertonic bladder *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 33.33 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 66.67 %

Gender of people who have Hypertonic bladder when taking Nexium 24hr *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Hypertonic bladder when taking Nexium 24hr *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 50 %
  • 50-59: 25 %
  • 60+: 25 %

Common drugs people take besides Nexium 24hr *:

  1. Nexium: 4 people, 66.67%
  2. Prilosec: 4 people, 66.67%
  3. Prevacid: 4 people, 66.67%
  4. Prevacid 24 Hr: 4 people, 66.67%
  5. Dexilant: 2 people, 33.33%
  6. Fish Oil: 2 people, 33.33%
  7. Aciphex: 2 people, 33.33%
  8. Prilosec Otc: 1 person, 16.67%
  9. Promethazine: 1 person, 16.67%
  10. Baclofen: 1 person, 16.67%

Common side effects people have besides Hypertonic bladder *:

  1. Acute Kidney Failure: 4 people, 66.67%
  2. Chronic Kidney Disease: 4 people, 66.67%
  3. Urination - Painful: 2 people, 33.33%
  4. Blood Creatinine Increased: 2 people, 33.33%
  5. Hypertensive Nephropathy (hypertensive renal disease): 2 people, 33.33%
  6. Micturition Urgency (urgency to pass the urine): 2 people, 33.33%
  7. Diarrhea: 2 people, 33.33%
  8. Weight Increased: 1 person, 16.67%
  9. Feeling Jittery: 1 person, 16.67%
  10. Indigestion: 1 person, 16.67%

Common conditions people have *:

  1. Stress And Anxiety: 2 people, 33.33%
  2. Pain: 2 people, 33.33%
  3. High Blood Cholesterol: 2 people, 33.33%
  4. Swallowing Difficulty: 1 person, 16.67%
  5. Presbyoesophagus (abnormal shape of the swallowing tube): 1 person, 16.67%
  6. Nausea (feeling of having an urge to vomit): 1 person, 16.67%
  7. Migraine (headache): 1 person, 16.67%
  8. Indigestion: 1 person, 16.67%
  9. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 16.67%
  10. Hypersensitivity: 1 person, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Nexium 24hr and have Hypertonic bladder?

Check whether Hypertonic bladder is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Hypertonic bladder and when was it recovered:

Expand to all the drugs that have ingredients of esomeprazole magnesium:

Alternative drugs to, pros and cons of Nexium 24hr:

Common Nexium 24hr side effects:

Browse all side effects of Nexium 24hr:

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Hypertonic bladder treatments and more:

COVID vaccines that are related to Hypertonic bladder:

Common drugs associated with Hypertonic bladder:

All the drugs that are associated with Hypertonic bladder:

Common conditions associated with Hypertonic bladder:

All the conditions that are associated with Hypertonic bladder:

How the study uses the data?

The study uses data from the FDA. It is based on esomeprazole magnesium (the active ingredients of Nexium 24hr) and Nexium 24hr (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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