Nexium and Abnormal weight gain - a phase IV clinical study of FDA data


We study 237,574 people who have side effects when taking Nexium. Abnormal weight gain is found, especially among people who are female, 20-29 old, also take Celebrex and have High blood pressure.

The phase IV clinical study analyzes which people take Nexium and have Abnormal weight gain. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 30, 2023

237,574 people reported to have side effects when taking Nexium.
Among them, 16 people (0.01%) have Abnormal weight gain.

What is Nexium?

Nexium has active ingredients of esomeprazole magnesium. It is used in gastroesophageal reflux disease. Currently, eHealthMe is studying from 242,320 Nexium users.

What is Abnormal weight gain?

Abnormal weight gain is found to be associated with 820 drugs and 654 conditions by eHealthMe. Currently, we are studying 17,582 people who have Abnormal weight gain.

Number of Nexium and Abnormal weight gain reports submitted per year:

Could Nexium cause Abnormal weight gain?

Gender of people who have Abnormal weight gain when taking Nexium *:

  • female: 60 %
  • male: 40 %

Age of people who have Abnormal weight gain when taking Nexium *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 7.14 %
  • 20-29: 28.57 %
  • 30-39: 7.14 %
  • 40-49: 14.29 %
  • 50-59: 21.43 %
  • 60+: 21.43 %

Common drugs people take besides Nexium *:

  1. Celebrex: 5 people, 31.25%
  2. Ambien: 3 people, 18.75%
  3. Vicodin: 3 people, 18.75%
  4. Seroquel: 3 people, 18.75%
  5. Oxycet: 3 people, 18.75%
  6. Remicade: 3 people, 18.75%
  7. Zantac: 3 people, 18.75%
  8. Inderal: 3 people, 18.75%
  9. Lexapro: 2 people, 12.50%
  10. Norvasc: 2 people, 12.50%

Common side effects people have besides Abnormal weight gain *:

  1. Weakness: 5 people, 31.25%
  2. Fatigue (feeling of tiredness): 4 people, 25.00%
  3. Abdominal Pain: 4 people, 25.00%
  4. Nausea And Vomiting: 4 people, 25.00%
  5. Stress And Anxiety: 3 people, 18.75%
  6. Nausea (feeling of having an urge to vomit): 3 people, 18.75%
  7. Confusional State: 3 people, 18.75%
  8. Head Injury: 3 people, 18.75%
  9. Feeling Abnormal: 3 people, 18.75%
  10. Arrhythmias (irregular heartbeat): 3 people, 18.75%

Common conditions people have *:

  1. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 18.75%
  2. Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 18.75%
  3. High Blood Pressure: 3 people, 18.75%
  4. Vitamin D Decreased: 2 people, 12.50%
  5. Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 12.50%
  6. High Blood Cholesterol: 2 people, 12.50%
  7. Abdominal Discomfort: 2 people, 12.50%
  8. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 12.50%
  9. Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 1 person, 6.25%
  10. Diabetes: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Nexium and have Abnormal weight gain?

Check whether Abnormal weight gain is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Nexium side effects by duration, gender and age:

Abnormal weight gain treatments and more:

Common drugs associated with Abnormal weight gain:

All the drugs that are associated with Abnormal weight gain:

Common conditions associated with Abnormal weight gain:

All the conditions that are associated with Abnormal weight gain:

How the study uses the data?

The study uses data from the FDA. It is based on esomeprazole magnesium (the active ingredients of Nexium) and Nexium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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