Nexium and Z-e syndrome - a phase IV clinical study of FDA data


We study 237,574 people who have side effects when taking Nexium. Z-e syndrome is found, especially among people who are male, 50-59 old, have been taking the drug for 2 - 5 years, also take Prilosec and have Gastritis.

The phase IV clinical study analyzes which people take Nexium and have Z-e syndrome. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 03, 2023

237,574 people reported to have side effects when taking Nexium.
Among them, 13 people (0.01%) have Z-e syndrome.

What is Nexium?

Nexium has active ingredients of esomeprazole magnesium. It is used in gastroesophageal reflux disease. Currently, eHealthMe is studying from 242,320 Nexium users.

What is Z-e syndrome?

Z-e syndrome (increased production of the hormone gastrin from a small tumour of pancreas) is found to be associated with 145 drugs and 173 conditions by eHealthMe. Currently, we are studying 1,239 people who have Z-e syndrome.

Number of Nexium and Z-e syndrome reports submitted per year:

Could Nexium cause Z-e syndrome?

Time on Nexium when people have Z-e syndrome *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 100 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Z-e syndrome when taking Nexium *:

  • female: 38.46 %
  • male: 61.54 %

Age of people who have Z-e syndrome when taking Nexium *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 10 %
  • 50-59: 50 %
  • 60+: 40 %

Common drugs people take besides Nexium *:

  1. Prilosec Otc: 5 people, 38.46%
  2. Prilosec: 5 people, 38.46%
  3. Protonix: 4 people, 30.77%
  4. Sucralfate: 3 people, 23.08%
  5. Prevacid: 3 people, 23.08%
  6. Lovastatin: 3 people, 23.08%
  7. Prednisone: 2 people, 15.38%
  8. Omeprazole: 2 people, 15.38%
  9. Lasix: 1 person, 7.69%
  10. Chantix: 1 person, 7.69%

Common side effects people have besides Z-e syndrome *:

  1. Oesophageal Stenosis (narrowing of oesophagus): 5 people, 38.46%
  2. Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 5 people, 38.46%
  3. Chronic Kidney Disease: 4 people, 30.77%
  4. Acquired Oesophageal Web (structural abnormalities in the oesophagus): 4 people, 30.77%
  5. Acute Kidney Failure: 4 people, 30.77%
  6. Gastritis (inflammation of stomach): 4 people, 30.77%
  7. Renal Cell Carcinoma (a kidney cancer): 4 people, 30.77%
  8. Interstitial Nephritis (inflammation of the kidney): 4 people, 30.77%
  9. Renal Cyst (kidney cyst): 3 people, 23.08%
  10. Neoplasm Malignant (cancer tumour): 2 people, 15.38%

Common conditions people have *:

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 7.69%
  2. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 1 person, 7.69%
  3. Oesophageal Spasm (contraction of oesophagus): 1 person, 7.69%
  4. Irritable Bowel Syndrome: 1 person, 7.69%
  5. Intervertebral Disc Degeneration (spinal disc degeneration): 1 person, 7.69%
  6. Ill-Defined Disorder: 1 person, 7.69%
  7. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 7.69%
  8. Hypersensitivity: 1 person, 7.69%
  9. Gout (uric acid crystals building up in the body): 1 person, 7.69%
  10. Gastritis (inflammation of stomach): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Nexium and have Z-e syndrome?

Check whether Z-e syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

Nexium side effects by duration, gender and age:

Z-e syndrome treatments and more:

All the drugs that are associated with Z-e syndrome:

All the conditions that are associated with Z-e syndrome:

How the study uses the data?

The study uses data from the FDA. It is based on esomeprazole magnesium (the active ingredients of Nexium) and Nexium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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