Nicotine and Application site erythema - a phase IV clinical study of FDA data
Summary:
Application site erythema is found among people who take Nicotine, especially for people who are female, 60+ old, have been taking the drug for < 1 month.
The phase IV clinical study analyzes which people take Nicotine and have Application site erythema. It is created by eHealthMe based on reports of 17,828 people who have side effects when taking Nicotine from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.
Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.
17,828 people reported to have side effects when taking Nicotine.
Among them, 532 people (2.98%) have Application site erythema.
What is Nicotine?
Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 16,826 Nicotine users for its effectiveness, alternative drugs and more.
What is Application site erythema?
Application site erythema (redness of the skin at application site) is found to be associated with 1,171 drugs and 880 conditions by eHealthMe.
Number of Nicotine and Application site erythema reports submitted per year:

Time on Nicotine when people have Application site erythema *:
Gender of people who have Application site erythema when taking Nicotine*:
Age of people who have Application site erythema when taking Nicotine *:
Common drugs people take besides Nicotine *:
Common side effects people have besides Application site erythema *:
Common conditions people have *:
* Approximation only. Some reports may have incomplete information.
Do you take Nicotine and have Application site erythema?
Check whether Application site erythema is associated with a drug or a conditionHow to use the study?
You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.
Related studies
How severe was Application site erythema and when was it recovered:
Expand to all the drugs that have ingredients of nicotine:
- Application site erythema and drugs with ingredients of nicotine (3,421 reports)
Alternative drugs to, pros and cons of Nicotine:
- Nicotine (16,826 reports)
Common Nicotine side effects:
- Abdominal discomfort: 124 reports
- Abdominal distension: 111 reports
- Abdominal pain: 222 reports
- Abdominal pain upper: 188 reports
- Abnormal dreams: 281 reports
- Accidental overdose (therapeutic agent): 281 reports
- Acute kidney failure: 232 reports
- Aggression: 102 reports
- Agitation (state of anxiety or nervous excitement): 250 reports
- Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 104 reports
- Anaemia (lack of blood): 202 reports
- Anger: 140 reports
- Anhedonia (inability to experience pleasure from activities usually found enjoyable): 128 reports
- Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 192 reports
- Application site erythema (redness of the skin at application site): 532 reports
- Application site irritation: 122 reports
- Application site pain: 249 reports
- Application site pruritus (application site severe itching of the skin): 462 reports
- Application site rash: 318 reports
- Application site reaction: 143 reports
- Application site swelling: 110 reports
- Arrhythmias (irregular heartbeat): 231 reports
- Asthma: 150 reports
- Back pain: 240 reports
- Blood creatinine increased: 114 reports
- Blood glucose increased: 137 reports
- Breathing difficulty: 736 reports
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 147 reports
- Cardiac arrest: 114 reports
- Cellulitis (infection under the skin): 107 reports
- Chest pain: 477 reports
- Chronic kidney disease: 213 reports
- Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe): 252 reports
- Completed suicide (act of taking one's own life): 168 reports
- Confusional state: 245 reports
- Constipation: 243 reports
- Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 162 reports
- Cough: 269 reports
- Death: 282 reports
- Dehydration (dryness resulting from the removal of water): 141 reports
- Dependence: 119 reports
- Depressed mood: 126 reports
- Depression: 441 reports
- Diabetes: 112 reports
- Diarrhea: 451 reports
- Disturbance in attention: 111 reports
- Dizziness: 801 reports
- Drowsiness: 279 reports
- Drug abuse and dependence: 338 reports
- Drug administration error: 120 reports
- Drug dependence: 507 reports
- Drug hypersensitivity: 171 reports
- Drug ineffective: 1,456 reports
- Drug toxicity: 166 reports
- Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 231 reports
- Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother): 435 reports
- Dry mouth: 113 reports
- Emotional distress: 143 reports
- Fainting (loss of consciousness and postural tone): 152 reports
- Fall: 274 reports
- Fatigue (feeling of tiredness): 558 reports
- Fever: 312 reports
- Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 823 reports
- Gait disturbance: 173 reports
- Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 140 reports
- General physical health deterioration (weak health status): 106 reports
- Hallucinations (sensations that appear real but are created by your mind): 183 reports
- Headache (pain in head): 642 reports
- Head injury: 133 reports
- Heart attack: 245 reports
- Heart palpitations (feelings or sensations that your heart is pounding or racing): 278 reports
- Heart rate increased: 195 reports
- High blood cholesterol: 116 reports
- High blood pressure: 506 reports
- Hyperhidrosis (abnormally increased sweating): 264 reports
- Hypersensitivity: 254 reports
- Hypoaesthesia (reduced sense of touch or sensation): 185 reports
- Hypotension (abnormally low blood pressure): 383 reports
- Indigestion: 124 reports
- Injury: 153 reports
- Insomnia (sleeplessness): 483 reports
- Irritability: 219 reports
- Itching: 303 reports
- Jaundice neonatal (yellowing of skin in neonate): 122 reports
- Joint pain: 206 reports
- Loss of consciousness: 325 reports
- Low birth weight baby: 190 reports
- Malaise (a feeling of general discomfort or uneasiness): 527 reports
- Maternal exposure during pregnancy (use of substance during pregnancy): 485 reports
- Memory loss: 166 reports
- Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 101 reports
- Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 105 reports
- Mood swings (an extreme or rapid change in mood): 123 reports
- Multiple drug overdose: 147 reports
- Muscle aches (muscle pain): 135 reports
- Muscle spasms (muscle contraction): 122 reports
- Nausea (feeling of having an urge to vomit): 1,170 reports
- Nausea and vomiting: 589 reports
- Nervousness: 173 reports
- Nicotine dependence: 845 reports
- Nightmares (unpleasant dreams): 190 reports
- Oedema peripheral (superficial swelling): 169 reports
- Overdose: 826 reports
- Pain: 498 reports
- Pain in extremity: 312 reports
- Panic disorder: 140 reports
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 233 reports
- Pleural effusion (water on the lungs): 137 reports
- Pneumonia: 389 reports
- Premature baby: 420 reports
- Premature delivery: 313 reports
- Pulmonary embolism (blockage of the main artery of the lung): 127 reports
- Pulmonary oedema (fluid accumulation in the lungs): 209 reports
- Quit smoking: 111 reports
- Rashes (redness): 644 reports
- Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 204 reports
- Sepsis (a severe blood infection that can lead to organ failure and death): 144 reports
- Sleep disorder: 176 reports
- Speech impairment (adult) (inability to speak (adult)): 136 reports
- Stress and anxiety: 821 reports
- Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 149 reports
- Suicidal ideation: 214 reports
- Swelling: 103 reports
- Thrombocytopenia (decrease of platelets in blood): 136 reports
- Tremor (trembling or shaking movements in one or more parts of your body): 296 reports
- Urinary tract infection: 169 reports
- Urticaria (rash of round, red welts on the skin that itch intensely): 166 reports
- Ventricular septal defect (a hole in the heart, is a common heart defect that's present at birth (congenital)): 122 reports
- Vision blurred: 156 reports
- Weakness: 412 reports
- Weight decreased: 246 reports
- Weight increased: 228 reports
- Wheezing (a high-pitched whistling sound made while you breath): 123 reports
- Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 137 reports
Browse all side effects of Nicotine:
a b c d e f g h i j k l m n o p q r s t u v w x y zApplication site erythema treatments and more:
- Application site erythema (24,256 reports)
COVID vaccines that are related to Application site erythema:
- Application site erythema in Moderna COVID Vaccine
- Application site erythema in Pfizer BioNTech Covid Vaccine
- Application site erythema in Johnson and Johnson Covid Vaccine
Common drugs associated with Application site erythema:
- Abreva: 274 reports
- Aldara: 119 reports
- Amlodipine: 172 reports
- Androderm: 150 reports
- Androgel: 101 reports
- Aspirin: 466 reports
- Atenolol: 164 reports
- Axiron: 133 reports
- Butrans: 1,550 reports
- Calcium: 158 reports
- Catapres-tts-1: 238 reports
- Climara: 170 reports
- Clonazepam: 108 reports
- Clonidine: 258 reports
- Combipatch: 218 reports
- Coumadin: 101 reports
- Crestor: 107 reports
- Cymbalta: 139 reports
- Daytrana: 1,879 reports
- Duragesic: 400 reports
- Duragesic-100: 280 reports
- Elidel: 147 reports
- Emsam: 198 reports
- Exelon: 192 reports
- Fentanyl: 279 reports
- Fentanyl-100: 107 reports
- Fish oil: 144 reports
- Gabapentin: 214 reports
- Habitrol: 149 reports
- Hydrochlorothiazide: 175 reports
- Ibuprofen: 114 reports
- Levothyroxine sodium: 117 reports
- Lexapro: 113 reports
- Lipitor: 208 reports
- Lisinopril: 305 reports
- Losartan: 136 reports
- Lyrica: 134 reports
- Metformin: 224 reports
- Methotrexate: 117 reports
- Minivelle: 154 reports
- Minoxidil: 388 reports
- Multivitamin: 143 reports
- Neulasta: 134 reports
- Neupro: 383 reports
- Nexium: 137 reports
- Nicoderm cq: 2,827 reports
- Nicorette: 197 reports
- Nicotine: 532 reports
- Omeprazole: 240 reports
- Oxycodone: 106 reports
- Oxytrol for women: 781 reports
- Percocet: 126 reports
- Picato: 2,484 reports
- Prednisone: 121 reports
- Progesterone: 108 reports
- Regranex: 101 reports
- Rogaine: 308 reports
- Simvastatin: 244 reports
- Singulair: 135 reports
- Synthroid: 345 reports
- Topamax: 102 reports
- Tramadol: 105 reports
- Valchlor: 239 reports
- Vitamin b12: 102 reports
- Vitamin d: 223 reports
- Vitamins: 152 reports
- Voltaren: 134 reports
- Wellbutrin: 120 reports
- Xanax: 145 reports
- Xulane: 102 reports
- Zecuity: 2,025 reports
- Zoloft: 118 reports
- Zyrtec: 141 reports
All the drugs that are associated with Application site erythema:
- Application site erythema (1,171 drugs)
Common conditions associated with Application site erythema:
- Acid reflux: 163 reports
- Acne: 221 reports
- Actinic keratosis: 1,766 reports
- Add: 1,368 reports
- Adhd: 1,368 reports
- Antidepressant therapy: 379 reports
- Anxiety: 232 reports
- Anxiety aggravated: 232 reports
- Anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension: 246 reports
- Arthralgia: 150 reports
- Arthritis: 142 reports
- Attention deficit disorder with hyperactivity: 1,417 reports
- Attention deficit hyperactivity disorder: 1,417 reports
- Attention deficit/hyperactivity disorder: 1,216 reports
- Attention deficit hyperactivity disorder (adhd): 1,435 reports
- Back pain: 400 reports
- Birth control: 173 reports
- Blood cholesterol abnormal: 400 reports
- Blood cholesterol increased: 385 reports
- Blood pressure abnormal: 158 reports
- Blood pressure increased: 760 reports
- Blood testosterone decreased: 241 reports
- Blood triglycerides abnormal: 385 reports
- Blood triglycerides increased: 400 reports
- Breakthrough pain: 154 reports
- Cessation of smoking: 1,453 reports
- Contraception: 174 reports
- Dementia alzheimer's type: 196 reports
- Depression: 366 reports
- Diabetes: 144 reports
- Diabetes mellitus: 145 reports
- Dm: 144 reports
- Fibromyalgia: 108 reports
- Fibromyalgia syndrome: 108 reports
- Gastroesophageal reflux disease: 167 reports
- Gastro-oesophageal reflux disease: 167 reports
- Gastrooesophageal reflux disease: 163 reports
- Gerd: 163 reports
- Hair loss: 409 reports
- Hbp: 760 reports
- Headache: 275 reports
- High blood cholesterol: 385 reports
- High blood pressure: 760 reports
- Hormone replacement therapy: 451 reports
- Hormone therapy: 434 reports
- Hot flash: 277 reports
- Hot flashes: 277 reports
- Hot flush: 277 reports
- Hot flushes aggravated: 280 reports
- Hrt: 434 reports
- Hypercholesterolaemia: 385 reports
- Hyperlipidemia: 385 reports
- Hypertension: 760 reports
- Hypertonic bladder: 282 reports
- Hypothyroid: 161 reports
- Hypothyroidism: 158 reports
- Insomnia: 105 reports
- Joint pain: 150 reports
- Keratosis - actinic (solar): 1,758 reports
- Menopause hot flashes: 280 reports
- Migraine: 750 reports
- Migraines: 750 reports
- Mycosis fungoides: 166 reports
- Nerve pain: 146 reports
- Neuralgia: 146 reports
- Oral herpes: 160 reports
- Pain: 1,549 reports
- Pain relief: 1,544 reports
- Parkinsons: 126 reports
- Parkinson's disease: 248 reports
- Periodic limb movement disorder: 189 reports
- Precancerous skin lesion: 364 reports
- Pregnancy: 173 reports
- Primary pulmonary hypertension: 115 reports
- Quit smoking: 1,469 reports
- Rash: 141 reports
- Rashes: 141 reports
- Restless leg syndrome: 189 reports
- Rheumatoid arthritis: 139 reports
- Rosacea: 140 reports
- Skin rash: 141 reports
- Sleep disorder: 143 reports
- Sleep disorder due to general medical condition, insomnia type: 143 reports
- Sleep disorder therapy: 143 reports
- Sleep issues: 105 reports
- Sleep - too much: 143 reports
- Smoker: 1,453 reports
- Smoking and smokeless tobacco: 1,453 reports
- Smoking cessation therapy: 1,469 reports
- Solar keratosis: 1,758 reports
- Stop smoking: 1,453 reports
- Stress: 226 reports
- Stress and anxiety: 226 reports
- Sun-induced skin changes - keratosis: 1,766 reports
- Thyroid diseases: 134 reports
- Tobacco user: 1,453 reports
All the conditions that are associated with Application site erythema:
- Application site erythema (880 conditions)
How the study uses the data?
The study uses data from the FDA. It is based on nicotine (the active ingredients of Nicotine) and Nicotine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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