Nicotine and Application site erythema - a phase IV clinical study of FDA data

• Nicotine (16,826 reports)

• Abdominal discomfort: 124 reports
• Abdominal distension: 111 reports
• Abdominal pain: 222 reports
• Abdominal pain upper: 188 reports
• Abnormal dreams: 281 reports
• Accidental overdose (therapeutic agent): 281 reports
• Acute kidney failure: 232 reports
• Aggression: 102 reports
• Agitation (state of anxiety or nervous excitement): 250 reports
• Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 104 reports
• Anaemia (lack of blood): 202 reports
• Anger: 140 reports
• Anhedonia (inability to experience pleasure from activities usually found enjoyable): 128 reports
• Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 192 reports
• Application site erythema (redness of the skin at application site): 532 reports
• Application site irritation: 122 reports
• Application site pain: 249 reports
• Application site pruritus (application site severe itching of the skin): 462 reports
• Application site rash: 318 reports
• Application site reaction: 143 reports
• Application site swelling: 110 reports
• Arrhythmias (irregular heartbeat): 231 reports
• Asthma: 150 reports
• Back pain: 240 reports
• Blood creatinine increased: 114 reports
• Blood glucose increased: 137 reports
• Breathing difficulty: 736 reports
• Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 147 reports
• Cardiac arrest: 114 reports
• Cellulitis (infection under the skin): 107 reports
• Chest pain: 477 reports
• Chronic kidney disease: 213 reports
• Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe): 252 reports
• Completed suicide (act of taking one's own life): 168 reports
• Confusional state: 245 reports
• Constipation: 243 reports
• Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 162 reports
• Cough: 269 reports
• Death: 282 reports
• Dehydration (dryness resulting from the removal of water): 141 reports
• Dependence: 119 reports
• Depressed mood: 126 reports
• Depression: 441 reports
• Diabetes: 112 reports
• Diarrhea: 451 reports
• Disturbance in attention: 111 reports
• Dizziness: 801 reports
• Drowsiness: 279 reports
• Drug abuse and dependence: 338 reports
• Drug administration error: 120 reports
• Drug dependence: 507 reports
• Drug hypersensitivity: 171 reports
• Drug ineffective: 1,456 reports
• Drug toxicity: 166 reports
• Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 231 reports
• Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother): 435 reports
• Dry mouth: 113 reports
• Emotional distress: 143 reports
• Fainting (loss of consciousness and postural tone): 152 reports
• Fall: 274 reports
• Fatigue (feeling of tiredness): 558 reports
• Fever: 312 reports
• Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 823 reports
• Gait disturbance: 173 reports
• Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 140 reports
• General physical health deterioration (weak health status): 106 reports
• Hallucinations (sensations that appear real but are created by your mind): 183 reports
• Headache (pain in head): 642 reports
• Head injury: 133 reports
• Heart attack: 245 reports
• Heart palpitations (feelings or sensations that your heart is pounding or racing): 278 reports
• Heart rate increased: 195 reports
• High blood cholesterol: 116 reports
• High blood pressure: 506 reports
• Hyperhidrosis (abnormally increased sweating): 264 reports
• Hypersensitivity: 254 reports
• Hypoaesthesia (reduced sense of touch or sensation): 185 reports
• Hypotension (abnormally low blood pressure): 383 reports
• Indigestion: 124 reports
• Injury: 153 reports
• Insomnia (sleeplessness): 483 reports
• Irritability: 219 reports
• Itching: 303 reports
• Jaundice neonatal (yellowing of skin in neonate): 122 reports
• Joint pain: 206 reports
• Loss of consciousness: 325 reports
• Low birth weight baby: 190 reports
• Malaise (a feeling of general discomfort or uneasiness): 527 reports
• Maternal exposure during pregnancy (use of substance during pregnancy): 485 reports
• Memory loss: 166 reports
• Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 101 reports
• Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 105 reports
• Mood swings (an extreme or rapid change in mood): 123 reports
• Multiple drug overdose: 147 reports
• Muscle aches (muscle pain): 135 reports
• Muscle spasms (muscle contraction): 122 reports
• Nausea (feeling of having an urge to vomit): 1,170 reports
• Nausea and vomiting: 589 reports
• Nervousness: 173 reports
• Nicotine dependence: 845 reports
• Nightmares (unpleasant dreams): 190 reports
• Oedema peripheral (superficial swelling): 169 reports
• Overdose: 826 reports
• Pain: 498 reports
• Pain in extremity: 312 reports
• Panic disorder: 140 reports
• Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 233 reports
• Pleural effusion (water on the lungs): 137 reports
• Pneumonia: 389 reports
• Premature baby: 420 reports
• Premature delivery: 313 reports
• Pulmonary embolism (blockage of the main artery of the lung): 127 reports
• Pulmonary oedema (fluid accumulation in the lungs): 209 reports
• Quit smoking: 111 reports
• Rashes (redness): 644 reports
• Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 204 reports
• Sepsis (a severe blood infection that can lead to organ failure and death): 144 reports
• Sleep disorder: 176 reports
• Speech impairment (adult) (inability to speak (adult)): 136 reports
• Stress and anxiety: 821 reports
• Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 149 reports
• Suicidal ideation: 214 reports
• Swelling: 103 reports
• Thrombocytopenia (decrease of platelets in blood): 136 reports
• Tremor (trembling or shaking movements in one or more parts of your body): 296 reports
• Urinary tract infection: 169 reports
• Urticaria (rash of round, red welts on the skin that itch intensely): 166 reports
• Ventricular septal defect (a hole in the heart, is a common heart defect that's present at birth (congenital)): 122 reports
• Vision blurred: 156 reports
• Weakness: 412 reports
• Weight decreased: 246 reports
• Weight increased: 228 reports
• Wheezing (a high-pitched whistling sound made while you breath): 123 reports
• Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 137 reports

• Application site erythema (24,256 reports)

• Abreva: 274 reports
• Aldara: 119 reports
• Amlodipine: 172 reports
• Androderm: 150 reports
• Androgel: 101 reports
• Aspirin: 466 reports
• Atenolol: 164 reports
• Axiron: 133 reports
• Butrans: 1,550 reports
• Calcium: 158 reports
• Catapres-tts-1: 238 reports
• Climara: 170 reports
• Clonazepam: 108 reports
• Clonidine: 258 reports
• Combipatch: 218 reports
• Coumadin: 101 reports
• Crestor: 107 reports
• Cymbalta: 139 reports
• Daytrana: 1,879 reports
• Duragesic: 400 reports
• Duragesic-100: 280 reports
• Elidel: 147 reports
• Emsam: 198 reports
• Exelon: 192 reports
• Fentanyl: 279 reports
• Fentanyl-100: 107 reports
• Fish oil: 144 reports
• Gabapentin: 214 reports
• Habitrol: 149 reports
• Hydrochlorothiazide: 175 reports
• Ibuprofen: 114 reports
• Levothyroxine sodium: 117 reports
• Lexapro: 113 reports
• Lipitor: 208 reports
• Lisinopril: 305 reports
• Losartan: 136 reports
• Lyrica: 134 reports
• Metformin: 224 reports
• Methotrexate: 117 reports
• Minivelle: 154 reports
• Minoxidil: 388 reports
• Multivitamin: 143 reports
• Neulasta: 134 reports
• Neupro: 383 reports
• Nexium: 137 reports
• Nicoderm cq: 2,827 reports
• Nicorette: 197 reports
• Nicotine: 532 reports
• Omeprazole: 240 reports
• Oxycodone: 106 reports
• Oxytrol for women: 781 reports
• Percocet: 126 reports
• Picato: 2,484 reports
• Prednisone: 121 reports
• Progesterone: 108 reports
• Regranex: 101 reports
• Rogaine: 308 reports
• Simvastatin: 244 reports
• Singulair: 135 reports
• Synthroid: 345 reports
• Topamax: 102 reports
• Tramadol: 105 reports
• Valchlor: 239 reports
• Vitamin b12: 102 reports
• Vitamin d: 223 reports
• Vitamins: 152 reports
• Voltaren: 134 reports
• Wellbutrin: 120 reports
• Xanax: 145 reports
• Xulane: 102 reports
• Zecuity: 2,025 reports
• Zoloft: 118 reports
• Zyrtec: 141 reports

All the drugs that are associated with Application site erythema:

• Application site erythema (1,171 drugs)

• Acid reflux: 163 reports
• Acne: 221 reports
• Actinic keratosis: 1,766 reports
• Add: 1,368 reports
• Adhd: 1,368 reports
• Antidepressant therapy: 379 reports
• Anxiety: 232 reports
• Anxiety aggravated: 232 reports
• Anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension: 246 reports
• Arthralgia: 150 reports
• Arthritis: 142 reports
• Attention deficit disorder with hyperactivity: 1,417 reports
• Attention deficit hyperactivity disorder: 1,417 reports
• Attention deficit/hyperactivity disorder: 1,216 reports
• Attention deficit hyperactivity disorder (adhd): 1,435 reports
• Back pain: 400 reports
• Birth control: 173 reports
• Blood cholesterol abnormal: 400 reports
• Blood cholesterol increased: 385 reports
• Blood pressure abnormal: 158 reports
• Blood pressure increased: 760 reports
• Blood testosterone decreased: 241 reports
• Blood triglycerides abnormal: 385 reports
• Blood triglycerides increased: 400 reports
• Breakthrough pain: 154 reports
• Cessation of smoking: 1,453 reports
• Contraception: 174 reports
• Dementia alzheimer's type: 196 reports
• Depression: 366 reports
• Diabetes: 144 reports
• Diabetes mellitus: 145 reports
• Dm: 144 reports
• Fibromyalgia: 108 reports
• Fibromyalgia syndrome: 108 reports
• Gastroesophageal reflux disease: 167 reports
• Gastro-oesophageal reflux disease: 167 reports
• Gastrooesophageal reflux disease: 163 reports
• Gerd: 163 reports
• Hair loss: 409 reports
• Hbp: 760 reports
• Headache: 275 reports
• High blood cholesterol: 385 reports
• High blood pressure: 760 reports
• Hormone replacement therapy: 451 reports
• Hormone therapy: 434 reports
• Hot flash: 277 reports
• Hot flashes: 277 reports
• Hot flush: 277 reports
• Hot flushes aggravated: 280 reports
• Hrt: 434 reports
• Hypercholesterolaemia: 385 reports
• Hyperlipidemia: 385 reports
• Hypertension: 760 reports
• Hypertonic bladder: 282 reports
• Hypothyroid: 161 reports
• Hypothyroidism: 158 reports
• Insomnia: 105 reports
• Joint pain: 150 reports
• Keratosis - actinic (solar): 1,758 reports
• Menopause hot flashes: 280 reports
• Migraine: 750 reports
• Migraines: 750 reports
• Mycosis fungoides: 166 reports
• Nerve pain: 146 reports
• Neuralgia: 146 reports
• Oral herpes: 160 reports
• Pain: 1,549 reports
• Pain relief: 1,544 reports
• Parkinsons: 126 reports
• Parkinson's disease: 248 reports
• Periodic limb movement disorder: 189 reports
• Precancerous skin lesion: 364 reports
• Pregnancy: 173 reports
• Primary pulmonary hypertension: 115 reports
• Quit smoking: 1,469 reports
• Rash: 141 reports
• Rashes: 141 reports
• Restless leg syndrome: 189 reports
• Rheumatoid arthritis: 139 reports
• Rosacea: 140 reports
• Skin rash: 141 reports
• Sleep disorder: 143 reports
• Sleep disorder due to general medical condition, insomnia type: 143 reports
• Sleep disorder therapy: 143 reports
• Sleep issues: 105 reports
• Sleep - too much: 143 reports
• Smoker: 1,453 reports
• Smoking and smokeless tobacco: 1,453 reports
• Smoking cessation therapy: 1,469 reports
• Solar keratosis: 1,758 reports
• Stop smoking: 1,453 reports
• Stress: 226 reports
• Stress and anxiety: 226 reports
• Sun-induced skin changes - keratosis: 1,766 reports
• Thyroid diseases: 134 reports
• Tobacco user: 1,453 reports

All the conditions that are associated with Application site erythema:

• Application site erythema (880 conditions)

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).