Nicotine and Drug abuse and dependence - a phase IV clinical study of FDA data

• Nicotine (16,826 reports)

• Abdominal discomfort: 124 reports
• Abdominal distension: 111 reports
• Abdominal pain: 222 reports
• Abdominal pain upper: 188 reports
• Abnormal dreams: 281 reports
• Accidental overdose (therapeutic agent): 281 reports
• Acute kidney failure: 232 reports
• Aggression: 102 reports
• Agitation (state of anxiety or nervous excitement): 250 reports
• Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 104 reports
• Anaemia (lack of blood): 202 reports
• Anger: 140 reports
• Anhedonia (inability to experience pleasure from activities usually found enjoyable): 128 reports
• Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 192 reports
• Application site erythema (redness of the skin at application site): 505 reports
• Application site irritation: 122 reports
• Application site pain: 236 reports
• Application site pruritus (application site severe itching of the skin): 462 reports
• Application site rash: 318 reports
• Application site reaction: 143 reports
• Application site swelling: 110 reports
• Arrhythmias (irregular heartbeat): 231 reports
• Asthma: 150 reports
• Back pain: 240 reports
• Blood creatinine increased: 114 reports
• Blood glucose increased: 137 reports
• Breathing difficulty: 736 reports
• Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 147 reports
• Cardiac arrest: 114 reports
• Cellulitis (infection under the skin): 107 reports
• Chest pain: 477 reports
• Chronic kidney disease: 213 reports
• Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe): 252 reports
• Completed suicide (act of taking one's own life): 168 reports
• Confusional state: 232 reports
• Constipation: 243 reports
• Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 162 reports
• Cough: 269 reports
• Death: 282 reports
• Dehydration (dryness resulting from the removal of water): 141 reports
• Dependence: 119 reports
• Depressed mood: 126 reports
• Depression: 441 reports
• Diabetes: 112 reports
• Diarrhea: 451 reports
• Disturbance in attention: 111 reports
• Dizziness: 801 reports
• Drowsiness: 279 reports
• Drug abuse and dependence: 338 reports
• Drug administration error: 120 reports
• Drug dependence: 507 reports
• Drug hypersensitivity: 171 reports
• Drug ineffective: 1,456 reports
• Drug toxicity: 166 reports
• Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 231 reports
• Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother): 435 reports
• Dry mouth: 113 reports
• Emotional distress: 143 reports
• Fainting (loss of consciousness and postural tone): 152 reports
• Fall: 274 reports
• Fatigue (feeling of tiredness): 558 reports
• Fever: 312 reports
• Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 823 reports
• Gait disturbance: 173 reports
• Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 140 reports
• General physical health deterioration (weak health status): 106 reports
• Hallucinations (sensations that appear real but are created by your mind): 183 reports
• Headache (pain in head): 642 reports
• Head injury: 133 reports
• Heart attack: 245 reports
• Heart palpitations (feelings or sensations that your heart is pounding or racing): 278 reports
• Heart rate increased: 195 reports
• High blood cholesterol: 116 reports
• High blood pressure: 506 reports
• Hyperhidrosis (abnormally increased sweating): 264 reports
• Hypersensitivity: 254 reports
• Hypoaesthesia (reduced sense of touch or sensation): 185 reports
• Hypotension (abnormally low blood pressure): 383 reports
• Indigestion: 124 reports
• Injury: 153 reports
• Insomnia (sleeplessness): 483 reports
• Irritability: 219 reports
• Itching: 303 reports
• Jaundice neonatal (yellowing of skin in neonate): 122 reports
• Joint pain: 206 reports
• Loss of consciousness: 325 reports
• Low birth weight baby: 190 reports
• Malaise (a feeling of general discomfort or uneasiness): 527 reports
• Maternal exposure during pregnancy (use of substance during pregnancy): 485 reports
• Memory loss: 166 reports
• Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 101 reports
• Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 105 reports
• Mood swings (an extreme or rapid change in mood): 123 reports
• Multiple drug overdose: 147 reports
• Muscle aches (muscle pain): 135 reports
• Muscle spasms (muscle contraction): 122 reports
• Nausea (feeling of having an urge to vomit): 1,170 reports
• Nausea and vomiting: 589 reports
• Nervousness: 173 reports
• Nicotine dependence: 845 reports
• Nightmares (unpleasant dreams): 190 reports
• Oedema peripheral (superficial swelling): 169 reports
• Overdose: 826 reports
• Pain: 498 reports
• Pain in extremity: 301 reports
• Panic disorder: 140 reports
• Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 233 reports
• Pleural effusion (water on the lungs): 137 reports
• Pneumonia: 389 reports
• Premature baby: 420 reports
• Premature delivery: 313 reports
• Pulmonary embolism (blockage of the main artery of the lung): 127 reports
• Pulmonary oedema (fluid accumulation in the lungs): 209 reports
• Quit smoking: 111 reports
• Rashes (redness): 644 reports
• Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 204 reports
• Sepsis (a severe blood infection that can lead to organ failure and death): 144 reports
• Sleep disorder: 161 reports
• Speech impairment (adult) (inability to speak (adult)): 136 reports
• Stress and anxiety: 821 reports
• Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 149 reports
• Suicidal ideation: 214 reports
• Swelling: 103 reports
• Thrombocytopenia (decrease of platelets in blood): 136 reports
• Tremor (trembling or shaking movements in one or more parts of your body): 296 reports
• Urinary tract infection: 169 reports
• Urticaria (rash of round, red welts on the skin that itch intensely): 166 reports
• Ventricular septal defect (a hole in the heart, is a common heart defect that's present at birth (congenital)): 122 reports
• Vision blurred: 156 reports
• Weakness: 412 reports
• Weight decreased: 246 reports
• Weight increased: 228 reports
• Wheezing (a high-pitched whistling sound made while you breath): 123 reports
• Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 137 reports

• Drug abuse and dependence (76,515 reports)

• Abilify: 486 reports
• Acetaminophen: 727 reports
• Acetaminophen and hydrocodone bitartrate: 346 reports
• Acetylsalicylic acid: 294 reports
• Actiq: 1,544 reports
• Adderall: 297 reports
• Akineton: 147 reports
• Albuterol: 344 reports
• Alcohol: 2,179 reports
• Allegra: 109 reports
• Allopurinol: 191 reports
• Alprazolam: 7,963 reports
• Ambien: 775 reports
• Amisulpride: 145 reports
• Amlodipine: 355 reports
• Amoxicillin: 186 reports
• Aripiprazole: 321 reports
• Aspirin: 405 reports
• Atarax: 164 reports
• Atenolol: 349 reports
• Ativan: 413 reports
• Augmentin: 174 reports
• Baclofen: 405 reports
• Bamate: 228 reports
• Benadryl: 157 reports
• Bisoprolol fumarate: 119 reports
• Buprenorphine: 688 reports
• Bupropion hydrochloride: 185 reports
• Buspar: 165 reports
• Butrans: 1,505 reports
• Caffeine: 224 reports
• Cannabis: 973 reports
• Cannabis sativa: 107 reports
• Carbamazepine: 457 reports
• Carisoprodol: 158 reports
• Celebrex: 255 reports
• Celexa: 270 reports
• Cephalexin: 111 reports
• Citalopram hydrobromide: 488 reports
• Claritin: 121 reports
• Clonazepam: 2,099 reports
• Clonidine: 325 reports
• Clopra: 212 reports
• Clozapine: 323 reports
• Clozaril: 161 reports
• Coca: 1,892 reports
• Codeine: 1,587 reports
• Commit: 181 reports
• Concerta: 146 reports
• Coumadin: 258 reports
• Cymbalta: 543 reports
• Delsym: 140 reports
• Demerol: 259 reports
• Depakote: 217 reports
• Desoxyn: 101 reports
• Diazepam: 4,827 reports
• Diclofenac: 160 reports
• Dilaudid: 2,744 reports
• Diphen: 2,442 reports
• Diphenhydramine hydrochloride: 352 reports
• Duloxetine hydrochloride: 131 reports
• Duragesic: 2,232 reports
• Duragesic-100: 237 reports
• Effexor: 559 reports
• Effexor xr: 185 reports
• Elavil: 290 reports
• Escitalopram: 628 reports
• Escitalopram oxalate: 208 reports
• Exalgo: 316 reports
• Fentanyl: 2,673 reports
• Fentanyl citrate: 1,254 reports
• Fentora: 1,470 reports
• Flexeril: 231 reports
• Flonase: 104 reports
• Fluconazole: 107 reports
• Fluoxetine: 1,500 reports
• Fluoxetine hydrochloride: 262 reports
• Folic acid: 104 reports
• Fosamax: 153 reports
• Furosemide: 449 reports
• Gabapentin: 2,745 reports
• Guaifenesin: 114 reports
• Halcion: 188 reports
• Haldol: 322 reports
• Hydramine: 2,708 reports
• Hydrochlorothiazide: 220 reports
• Hydrocodone bitartrate and acetaminophen: 1,943 reports
• Hydromorphone hydrochloride: 357 reports
• Hydroxyzine: 533 reports
• Hysingla: 1,477 reports
• Hysingla er: 1,477 reports
• Ibu: 1,409 reports
• Ibuprofen: 1,250 reports
• Imitrex: 116 reports
• Imodium: 224 reports
• Inderal: 115 reports
• Kadian: 1,758 reports
• Keppra: 213 reports
• Ketalar: 161 reports
• Klonopin: 492 reports
• Lamictal: 225 reports
• Lamotrigine: 500 reports
• Lansoprazole: 232 reports
• Lantus: 103 reports
• Lasix: 429 reports
• Levaquin: 170 reports
• Levetiracetam: 208 reports
• Levothyroxine sodium: 110 reports
• Lexapro: 223 reports
• Lidocaine: 107 reports
• Lipitor: 177 reports
• Lisinopril: 303 reports
• Lithium carbonate: 169 reports
• Loperamide hydrochloride: 174 reports
• Lopurin: 193 reports
• Loraz: 3,429 reports
• Lorazepam: 3,429 reports
• Lorcet-hd: 228 reports
• Lortab: 622 reports
• Lyrica: 1,396 reports
• Marijuana: 668 reports
• Melatonin: 144 reports
• Meprobamate: 228 reports
• Metformin: 676 reports
• Metformin hydrochloride: 122 reports
• Methadone hydrochloride: 271 reports
• Methadose: 192 reports
• Methamphetamine hydrochloride: 108 reports
• Methotrexate: 158 reports
• Methylphenidate hydrochloride: 115 reports
• Metoclopramide: 211 reports
• Mirtazapine: 1,414 reports
• Morphine: 4,321 reports
• Morphine sulfate: 2,180 reports
• Motrin: 109 reports
• Ms contin: 2,212 reports
• Naproxen: 184 reports
• Neurontin: 738 reports
• Nexium: 216 reports
• Nicorette: 326 reports
• Nicotine: 338 reports
• Nitrous oxide: 115 reports
• Norco: 1,543 reports
• Norvasc: 245 reports
• Nucynta: 1,364 reports
• Olanzapine: 1,248 reports
• Omeprazole: 435 reports
• Ondansetron: 102 reports
• Opana: 2,190 reports
• Opana er: 1,944 reports
• Oxazepam: 587 reports
• Oxycodone: 4,148 reports
• Oxycodone and acetaminophen: 113 reports
• Oxycodone hydrochloride: 194 reports
• Oxycontin: 11,544 reports
• Oxymorphone hydrochloride: 586 reports
• Palladone: 107 reports
• Pantoprazole: 469 reports
• Paracetamol: 1,458 reports
• Paroxetine: 1,213 reports
• Paroxetine hydrochloride: 158 reports
• Paxil: 693 reports
• Pepcid: 115 reports
• Percocet: 3,654 reports
• Percodan: 1,166 reports
• Phenergan: 216 reports
• Phentermine: 113 reports
• Plavix: 133 reports
• Prednisolone: 155 reports
• Prednisone: 435 reports
• Pregabalin: 1,162 reports
• Premarin: 115 reports
• Prevacid: 206 reports
• Prilosec: 223 reports
• Profen: 1,264 reports
• Promethazine: 478 reports
• Propofol: 133 reports
• Protonix: 161 reports
• Provigil: 109 reports
• Prozac: 579 reports
• Quetiapine fumarate: 644 reports
• Quinine: 579 reports
• Ramipril: 402 reports
• Ranitidine: 159 reports
• Relpax: 107 reports
• Remeron: 268 reports
• Restoril: 132 reports
• Ribavirin: 103 reports
• Risperdal: 568 reports
• Risperidone: 429 reports
• Ritalin: 307 reports
• Roxicet: 115 reports
• Roxicodone: 712 reports
• Ryzolt: 149 reports
• Seroquel: 1,021 reports
• Sertraline: 1,973 reports
• Sertraline hydrochloride: 262 reports
• Simvastatin: 230 reports
• Singulair: 110 reports
• Soma: 507 reports
• Stadol: 1,768 reports
• Sublocade: 160 reports
• Suboxone: 1,056 reports
• Subsys: 353 reports
• Subutex: 581 reports
• Synthroid: 150 reports
• Tegretol: 280 reports
• Temaz: 646 reports
• Temazepam: 646 reports
• Topamax: 290 reports
• Topiramate: 249 reports
• Toradol: 107 reports
• Tramadol: 3,935 reports
• Tramadol hydrochloride: 730 reports
• Trazodone hydrochloride: 196 reports
• Triazolam: 318 reports
• Tylenol: 311 reports
• Tylenol w/ codeine: 107 reports
• Ultram: 757 reports
• Valium: 1,290 reports
• Valproate sodium: 111 reports
• Valproic acid: 242 reports
• Venlafaxine hydrochloride: 199 reports
• Ventolin: 108 reports
• Viagra: 139 reports
• Vicodin: 1,307 reports
• Vioxx: 324 reports
• Vistaril: 154 reports
• Vivitrol: 430 reports
• Voltaren: 156 reports
• Vyvanse: 111 reports
• Wellbutrin: 498 reports
• Xanax: 2,578 reports
• Xyrem: 362 reports
• Zanaflex: 165 reports
• Zantac: 125 reports
• Zide: 217 reports
• Zithromax: 124 reports
• Zofran: 129 reports
• Zoloft: 737 reports
• Zolpidem: 2,180 reports
• Zolpidem tartrate: 642 reports
• Zometa: 124 reports
• Zopiclone: 450 reports
• Zydone: 846 reports
• Zyprexa: 413 reports

All the drugs that are associated with Drug abuse and dependence:

• Drug abuse and dependence (2,099 drugs)

• Acid reflux: 106 reports
• Acupuncture and pain: 3,385 reports
• Add: 277 reports
• Addiction - drug: 3,279 reports
• Adhd: 277 reports
• Adult hypothyroidism: 153 reports
• Affective disorder: 114 reports
• Agitation: 117 reports
• Agrypnia: 1,036 reports
• Alcohol abuse: 393 reports
• Alcohol dependence: 375 reports
• Alcohol detoxification: 375 reports
• Alcoholism: 407 reports
• Alcohol problem: 393 reports
• Alcohol rehabilitation: 375 reports
• Alcohol use: 393 reports
• Alternative medicine - pain relief: 5,009 reports
• Analgesic therapy: 124 reports
• Antidepressant therapy: 2,030 reports
• Anxiety: 1,599 reports
• Anxiety aggravated: 1,460 reports
• Anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension: 1,455 reports
• Anxiety disorder: 131 reports
• Anxiety disorder due to a general medical condition: 163 reports
• Asthma: 165 reports
• Attention deficit disorder with hyperactivity: 277 reports
• Attention deficit hyperactivity disorder: 277 reports
• Attention deficit/hyperactivity disorder: 159 reports
• Attention deficit hyperactivity disorder (adhd): 277 reports
• Back pain: 1,068 reports
• Back pain aggravated: 905 reports
• Bipolar: 549 reports
• Bi-polar: 502 reports
• Bipolar disorder: 549 reports
• Blood cholesterol abnormal: 149 reports
• Blood cholesterol increased: 137 reports
• Blood pressure increased: 654 reports
• Blood triglycerides increased: 137 reports
• Bone and joint pain: 166 reports
• Breakthrough pain: 143 reports
• Bronchial asthma: 164 reports
• Cessation of smoking: 205 reports
• Childhood hyperkinesis: 277 reports
• Cigarette smoking: 192 reports
• Cocaine abuse: 5,562 reports
• Daytime sleep disorder: 213 reports
• Depression: 2,061 reports
• Depression aggravated: 2,050 reports
• Depression - major: 164 reports
• Diabetes: 188 reports
• Diabetes mellitus: 166 reports
• Diabetes mellitus management: 166 reports
• Difficulty falling asleep: 1,036 reports
• Dm: 166 reports
• Drug abuse: 5,061 reports
• Drug abuse and dependence: 2,858 reports
• Drug abuser: 3,278 reports
• Drug addiction: 3,278 reports
• Drug dependence: 1,325 reports
• Drug withdrawal syndrome: 149 reports
• Dyssomnia: 923 reports
• Epilepsy: 258 reports
• Epilepsy aggravated: 259 reports
• Euphoric mood: 135 reports
• Feeling uptight: 1,455 reports
• Fibromyalgia: 116 reports
• Fibromyositis: 116 reports
• Gad: 131 reports
• Gastroesophageal reflux disease: 106 reports
• Gastro-oesophageal reflux disease: 106 reports
• Gastrooesophageal reflux disease: 106 reports
• Generalised anxiety disorder: 131 reports
• Generalized anxiety disorder: 131 reports
• Gerd: 116 reports
• Gerds: 106 reports
• Hallucinogen abuse: 6,014 reports
• Hbp: 654 reports
• Headache: 313 reports
• Headaches: 325 reports
• Heartburn: 116 reports
• Heartburn - chronic: 106 reports
• Hepatitis c: 173 reports
• Heroin abuse: 6,014 reports
• High blood cholesterol: 149 reports
• High blood pressure: 654 reports
• High cholesterol: 149 reports
• Hiv: 138 reports
• Hiv infection: 138 reports
• Hiv test: 138 reports
• Htn: 654 reports
• Hypercholesterolaemia: 137 reports
• Hypercholesterolemia: 137 reports
• Hyperlipoproteinemia: 137 reports
• Hypertension: 657 reports
• Hypothyroid: 153 reports
• Hypothyroidism: 153 reports
• Ill-defined disorder: 135 reports
• Illicit drug abuse: 5,562 reports
• Inability to sleep: 923 reports
• Insomnia: 923 reports
• Insomnia concerns: 1,040 reports
• Insomnia exacerbated: 923 reports
• Intentional self-injury: 978 reports
• Jitters: 1,455 reports
• Joint pain: 200 reports
• Ldl/hdl ratio increased: 137 reports
• Lipid test: 137 reports
• Lipoprotein test: 137 reports
• Low thyroid: 153 reports
• Lsd abuse: 5,562 reports
• Major depression: 164 reports
• Major depressive disorder: 166 reports
• Marijuana abuse: 5,562 reports
• Mental disorder: 136 reports
• Migraine: 433 reports
• Migraines: 295 reports
• Ms: 236 reports
• Ms hug: 236 reports
• Multiple sclerosis: 233 reports
• Muscle building therapy: 104 reports
• Narcolepsy: 225 reports
• Narcotic abuse: 5,562 reports
• Neuralgia: 149 reports
• Non-a or non-b hepatitis: 170 reports
• Osteoporosis: 150 reports
• Pain: 5,280 reports
• Pain exacerbated: 5,226 reports
• Pain - head: 307 reports
• Pain management: 5,009 reports
• Pain relief by acupuncture: 4,492 reports
• Panic attack: 118 reports
• Panic disorder: 117 reports
• Parkinsonism aggravated: 202 reports
• Parkinson's disease: 202 reports
• Pcp abuse: 5,223 reports
• Personality disorder: 201 reports
• Postherpetic neuralgia: 147 reports
• Psychotic disorder: 217 reports
• Quit smoking: 205 reports
• Ra: 116 reports
• Restlessness: 117 reports
• Rheumatoid arthritis: 116 reports
• Schizophrenia: 487 reports
• Seizure: 134 reports
• Seizure disorder: 259 reports
• Sleep aid: 927 reports
• Sleep disorder: 350 reports
• Sleep disorder due to a general medical condition: 345 reports
• Sleep disorder due to general medical condition, insomnia type: 345 reports
• Sleep disorder therapy: 328 reports
• Sleeping: 923 reports
• Sleeping difficulty: 927 reports
• Sleep issues: 923 reports
• Sleep - too much: 345 reports
• Smoking and smokeless tobacco: 205 reports
• Smoking cessation: 205 reports
• Smoking cessation therapy: 207 reports
• Stiffness in a joint: 224 reports
• Stop smoking: 192 reports
• Stress: 1,455 reports
• Stress and anxiety: 1,455 reports
• Substance abuse: 5,223 reports
• Suicide attempt: 435 reports
• Tension: 1,455 reports
• Thin bones: 135 reports
• Tobacco abuse: 207 reports
• Tobacco user: 205 reports
• Under active thyroids: 153 reports
• Unipolar depression: 209 reports

All the conditions that are associated with Drug abuse and dependence:

• Drug abuse and dependence (1,365 conditions)

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