Nicotine and Macrocytosis - a phase IV clinical study of FDA data


Macrocytosis is found among people who take Nicotine, especially for people who are female, 50-59 old.

The phase IV clinical study analyzes which people take Nicotine and have Macrocytosis. It is created by eHealthMe based on reports of 17,828 people who have side effects when taking Nicotine from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 02, 2022

17,828 people reported to have side effects when taking Nicotine.
Among them, 7 people (0.04%) have Macrocytosis.

What is Nicotine?

Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 18,146 Nicotine users for its effectiveness, alternative drugs and more.

What is Macrocytosis?

Macrocytosis (enlargement of red blood cells with near-constant haemoglobin concentration) is found to be associated with 988 drugs and 530 conditions by eHealthMe.

Number of Nicotine and Macrocytosis reports submitted per year:

Could Nicotine cause Macrocytosis?

Gender of people who have Macrocytosis when taking Nicotine *:

  • female: 80 %
  • male: 20 %

Age of people who have Macrocytosis when taking Nicotine *:

  • 0-1: 25 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 50 %
  • 60+: 25 %

Common drugs people take besides Nicotine *:

  1. Fosamax: 4 people, 57.14%
  2. Chantix: 4 people, 57.14%
  3. Omega-3 Marine Triglycerides: 3 people, 42.86%
  4. Valium: 1 person, 14.29%
  5. Omega-3-Acid Ethyl Esters: 1 person, 14.29%
  6. Ms Contin: 1 person, 14.29%
  7. Lovenox: 1 person, 14.29%
  8. Duphalac: 1 person, 14.29%
  9. Depakote: 1 person, 14.29%

Common side effects people have besides Macrocytosis *:

  1. Yawning (simultaneous inhalation of air and stretching of the eardrums, followed by exhalation of breath): 4 people, 57.14%
  2. Low Turnover Osteopathy (slow removal of old bone and its replacement by new bone): 4 people, 57.14%
  3. Lactose Intolerance (inability to digest lactose): 4 people, 57.14%
  4. Joint Dislocation (a joint position is changed from normal position): 4 people, 57.14%
  5. Intervertebral Disc Displacement: 4 people, 57.14%
  6. Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 57.14%
  7. Hyperglycemia (high blood sugar): 4 people, 57.14%
  8. Herpes Simplex (herpes simplex is a common viral infection): 4 people, 57.14%
  9. Herniated Nucleus Pulposus (Slipped Disk): 4 people, 57.14%
  10. Hereditary Fructose Intolerance: 4 people, 57.14%

Common conditions people have *:

  1. Osteoporosis (bones weak and more likely to break): 4 people, 57.14%
  2. Osteopenia (a condition where bone mineral density is lower than normal): 4 people, 57.14%
  3. High Blood Pressure: 1 person, 14.29%
  4. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Nicotine and have Macrocytosis?

Check whether Macrocytosis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Macrocytosis and when was it recovered:

Expand to all the drugs that have ingredients of nicotine:

Alternative drugs to, pros and cons of Nicotine:

Common Nicotine side effects:

Browse all side effects of Nicotine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Macrocytosis treatments and more:

COVID vaccines that are related to Macrocytosis:

Common drugs associated with Macrocytosis:

All the drugs that are associated with Macrocytosis:

Common conditions associated with Macrocytosis:

All the conditions that are associated with Macrocytosis:

How the study uses the data?

The study uses data from the FDA. It is based on nicotine (the active ingredients of Nicotine) and Nicotine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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