Nicotine and Macular pigmentation - a phase IV clinical study of FDA data


Macular pigmentation is reported only by a few people who take Nicotine.

The phase IV clinical study analyzes which people take Nicotine and have Macular pigmentation. It is created by eHealthMe based on reports of 17,828 people who have side effects while taking Nicotine from the FDA, and is updated regularly.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Aug, 28, 2022

17,828 people reported to have side effects when taking Nicotine.
Among them, 5 people (0.03%) have Macular pigmentation.

What is Nicotine?

Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 18,139 Nicotine users for its effectiveness, alternative drugs and more.

What is Macular pigmentation?

Macular pigmentation (pigmented yellow spot near the centre of the retina) is found to be associated with 110 drugs and 95 conditions by eHealthMe.

Number of Nicotine and Macular pigmentation reports submitted per year:

Could Nicotine cause Macular pigmentation?

Gender of people who have Macular pigmentation when taking Nicotine *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Macular pigmentation when taking Nicotine *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 100 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

Common drugs people take besides Nicotine *:

  1. Paracetamol: 5 people, 100.00%
  2. Mirabegron: 5 people, 100.00%
  3. Colecalciferol: 5 people, 100.00%

Common side effects people have besides Macular pigmentation *:

  1. Urticaria (rash of round, red welts on the skin that itch intensely): 5 people, 100.00%
  2. Urinary Tract Infection: 5 people, 100.00%
  3. Back Pain: 5 people, 100.00%
  4. Blood Folate Decreased: 5 people, 100.00%
  5. Diarrhea: 5 people, 100.00%
  6. Dizziness: 5 people, 100.00%
  7. Face Oedema (swelling of face): 5 people, 100.00%
  8. Fatigue (feeling of tiredness): 5 people, 100.00%
  9. Fever: 5 people, 100.00%
  10. Gastroenteritis Viral (inflammation of stomach and intestine caused by virus infection): 5 people, 100.00%

Common conditions people have *:

  1. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 100.00%
  2. Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 80.00%

* Approximation only. Some reports may have incomplete information.

Do you take Nicotine and have Macular pigmentation?

Check whether Macular pigmentation is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Macular pigmentation and when was it recovered:

Expand to all the drugs that have ingredients of nicotine:

Alternative drugs to, pros and cons of Nicotine:

Common Nicotine side effects:

Browse all side effects of Nicotine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Macular pigmentation treatments and more:

COVID vaccines that are related to Macular pigmentation:

All the drugs that are associated with Macular pigmentation:

All the conditions that are associated with Macular pigmentation:

How the study uses the data?

The study uses data from the FDA. It is based on nicotine (the active ingredients of Nicotine) and Nicotine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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