Nicotine and Major depressive disorder - a phase IV clinical study of FDA data

Summary:

Major depressive disorder is found among people who take Nicotine, especially for people who are female, 20-29 old, have been taking the drug for 1 - 6 months.

The phase IV clinical study analyzes which people take Nicotine and have Major depressive disorder. It is created by eHealthMe based on reports of 17,828 people who have side effects when taking Nicotine from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.



On Sep, 18, 2022

17,828 people reported to have side effects when taking Nicotine.
Among them, 31 people (0.17%) have Major depressive disorder.


What is Nicotine?

Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 18,146 Nicotine users for its effectiveness, alternative drugs and more.

What is Major depressive disorder?

Major depressive disorder (a condition characterized by a long-lasting depressed mood or marked loss of interest or pleasure) is found to be associated with 1,930 drugs and 1,332 conditions by eHealthMe.

Number of Nicotine and Major depressive disorder reports submitted per year:

Could Nicotine cause Major depressive disorder?

Time on Nicotine when people have Major depressive disorder *:

  • < 1 month: 33.33 %
  • 1 - 6 months: 44.44 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 11.11 %
  • 10+ years: 11.11 %

Gender of people who have Major depressive disorder when taking Nicotine *:

  • female: 61.29 %
  • male: 38.71 %

Age of people who have Major depressive disorder when taking Nicotine *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 48 %
  • 30-39: 12 %
  • 40-49: 32 %
  • 50-59: 0.0 %
  • 60+: 8 %

Common drugs people take besides Nicotine *:

  1. Wellbutrin: 8 people, 25.81%
  2. Seroquel: 8 people, 25.81%
  3. Zyprexa: 7 people, 22.58%
  4. Vicodin: 7 people, 22.58%
  5. Ativan: 7 people, 22.58%
  6. Lexapro: 6 people, 19.35%
  7. Gabapentin: 6 people, 19.35%
  8. Klonopin: 6 people, 19.35%
  9. Effexor: 5 people, 16.13%
  10. Naproxen: 5 people, 16.13%

Common side effects people have besides Major depressive disorder *:

  1. Suicidal Ideation: 16 people, 51.61%
  2. Borderline Personality Disorder: 9 people, 29.03%
  3. Suicide Attempt: 7 people, 22.58%
  4. Pain: 6 people, 19.35%
  5. Back Pain: 6 people, 19.35%
  6. Neck Pain: 5 people, 16.13%
  7. Nausea (feeling of having an urge to vomit): 5 people, 16.13%
  8. Victim Of Abuse: 5 people, 16.13%
  9. Post-Traumatic Stress Disorder: 5 people, 16.13%
  10. Bipolar Disorder (mood disorder): 5 people, 16.13%

Common conditions people have *:

  1. Depression: 6 people, 19.35%
  2. Pain: 5 people, 16.13%
  3. Insomnia (sleeplessness): 4 people, 12.90%
  4. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 12.90%
  5. Sleep Disorder: 3 people, 9.68%
  6. Affective Disorder (mental disorder): 2 people, 6.45%
  7. Hiv Infection: 2 people, 6.45%
  8. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 2 people, 6.45%
  9. Bipolar Disorder (mood disorder): 2 people, 6.45%
  10. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 3.23%

* Approximation only. Some reports may have incomplete information.

Do you take Nicotine and have Major depressive disorder?

Check whether Major depressive disorder is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.



Related studies

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Expand to all the drugs that have ingredients of nicotine:

Alternative drugs to, pros and cons of Nicotine:

Common Nicotine side effects:

Browse all side effects of Nicotine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Major depressive disorder treatments and more:

COVID vaccines that are related to Major depressive disorder:

Common drugs associated with Major depressive disorder:

All the drugs that are associated with Major depressive disorder:

Common conditions associated with Major depressive disorder:

All the conditions that are associated with Major depressive disorder:

How the study uses the data?

The study uses data from the FDA. It is based on nicotine (the active ingredients of Nicotine) and Nicotine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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