Nicotine and Ulcerative colitis - a phase IV clinical study of FDA data


Ulcerative colitis is found among people who take Nicotine, especially for people who are female, 40-49 old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Nicotine and have Ulcerative colitis. It is created by eHealthMe based on reports of 17,828 people who have side effects when taking Nicotine from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Jan, 31, 2023

17,828 people reported to have side effects when taking Nicotine.
Among them, 47 people (0.26%) have Ulcerative colitis.

What is Nicotine?

Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 18,166 Nicotine users for its effectiveness, alternative drugs and more.

What is Ulcerative colitis?

Ulcerative colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine) is found to be associated with 2,431 drugs and 1,874 conditions by eHealthMe.

Number of Nicotine and Ulcerative colitis reports submitted per year:

Could Nicotine cause Ulcerative colitis?

Time on Nicotine when people have Ulcerative colitis *:

  • < 1 month: 66.67 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 33.33 %

Gender of people who have Ulcerative colitis when taking Nicotine *:

  • female: 72.34 %
  • male: 27.66 %

Age of people who have Ulcerative colitis when taking Nicotine *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 5.13 %
  • 30-39: 20.51 %
  • 40-49: 56.41 %
  • 50-59: 5.13 %
  • 60+: 12.82 %

Common drugs people take besides Nicotine *:

  1. Neurontin: 19 people, 40.43%
  2. Percocet: 18 people, 38.30%
  3. Combivent: 17 people, 36.17%
  4. Narcan: 17 people, 36.17%
  5. Moxifloxacin: 17 people, 36.17%
  6. Lidocaine: 17 people, 36.17%
  7. Lantus: 17 people, 36.17%
  8. Flovent: 17 people, 36.17%
  9. Dilaudid: 17 people, 36.17%
  10. Demerol: 17 people, 36.17%

Common side effects people have besides Ulcerative colitis *:

  1. Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 22 people, 46.81%
  2. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 21 people, 44.68%
  3. Diarrhea: 19 people, 40.43%
  4. Diarrhea Haemorrhagic: 18 people, 38.30%
  5. Pain: 18 people, 38.30%
  6. Dizziness: 18 people, 38.30%
  7. Intestinal Obstruction: 18 people, 38.30%
  8. Breathing Difficulty: 18 people, 38.30%
  9. Obstructive Airways Disorder (a progressive disease that makes it hard to breathe): 17 people, 36.17%
  10. Mastication Disorder (disease of chewing food): 17 people, 36.17%

Common conditions people have *:

  1. Osteopenia (a condition where bone mineral density is lower than normal): 17 people, 36.17%
  2. Crohn's Disease (condition that causes inflammation of the gastrointestinal tract): 5 people, 10.64%
  3. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 6.38%
  4. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 6.38%
  5. Abdominal Pain: 3 people, 6.38%
  6. Vitamin B12 Deficiency: 1 person, 2.13%
  7. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 2.13%
  8. Lipids Increased (excess lipid in body): 1 person, 2.13%
  9. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 2.13%
  10. Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 2.13%

* Approximation only. Some reports may have incomplete information.

Do you take Nicotine and have Ulcerative colitis?

Check whether Ulcerative colitis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Ulcerative colitis and when was it recovered:

Expand to all the drugs that have ingredients of nicotine:

Alternative drugs to, pros and cons of Nicotine:

Common Nicotine side effects:

Browse all side effects of Nicotine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Ulcerative colitis treatments and more:

COVID vaccines that are related to Ulcerative colitis:

Common drugs associated with Ulcerative colitis:

All the drugs that are associated with Ulcerative colitis:

Common conditions associated with Ulcerative colitis:

All the conditions that are associated with Ulcerative colitis:

How the study uses the data?

The study uses data from the FDA. It is based on nicotine (the active ingredients of Nicotine) and Nicotine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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