Norco and Dry eye syndrome - a phase IV clinical study of FDA data


Dry eye syndrome is reported only by a few people who take Norco.

The phase IV clinical study analyzes which people take Norco and have Dry eye syndrome. It is created by eHealthMe based on reports of 67,324 people who have side effects while taking Norco from the FDA, and is updated regularly.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Aug, 16, 2022

67,324 people reported to have side effects when taking Norco.
Among them, 5 people (0.01%) have Dry eye syndrome.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 65,779 Norco users for its effectiveness, alternative drugs and more.

What is Dry eye syndrome?

Dry eye syndrome is found to be associated with 879 drugs and 613 conditions by eHealthMe.

Number of Norco and Dry eye syndrome reports submitted per year:

Could Norco cause Dry eye syndrome?

Gender of people who have Dry eye syndrome when taking Norco *:

  • female: 80 %
  • male: 20 %

Age of people who have Dry eye syndrome when taking Norco *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 100 %
  • 60+: 0.0 %

Common drugs people take besides Norco *:

  1. Wellbutrin: 5 people, 100.00%
  2. Cymbalta: 5 people, 100.00%
  3. Lunesta: 5 people, 100.00%
  4. Zyrtec: 4 people, 80.00%
  5. Compazine: 4 people, 80.00%
  6. Loratadine: 4 people, 80.00%
  7. Zometa: 4 people, 80.00%
  8. Levaquin: 4 people, 80.00%
  9. Hydrocodone Bitartrate And Acetaminophen: 4 people, 80.00%
  10. Heparin: 4 people, 80.00%

Common side effects people have besides Dry eye syndrome *:

  1. Vertebral Foraminal Stenosis (narrowing of the intervertebral foramen): 4 people, 80.00%
  2. Emotional Distress: 4 people, 80.00%
  3. Fatigue (feeling of tiredness): 4 people, 80.00%
  4. Fever: 4 people, 80.00%
  5. Fibrosis (formation of excess fibrous connective tissue in an organ or tissue): 4 people, 80.00%
  6. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 80.00%
  7. Gums - Swollen: 4 people, 80.00%
  8. Hair Loss: 4 people, 80.00%
  9. Hand-Foot-And-Mouth Disease: 4 people, 80.00%
  10. Hepatomegaly (abnormal enlargement of the liver): 4 people, 80.00%

Common conditions people have *:

  1. Osteomyelitis (infection of bone): 4 people, 80.00%
  2. Metastases To Bone (cancer spreads to bone): 4 people, 80.00%
  3. Breast Cancer: 4 people, 80.00%
  4. Bone Cancer Metastatic: 4 people, 80.00%
  5. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 20.00%

* Approximation only. Some reports may have incomplete information.

Do you take Norco and have Dry eye syndrome?

Check whether Dry eye syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Dry eye syndrome and when was it recovered:

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Alternative drugs to, pros and cons of Norco:

Common Norco side effects:

Browse all side effects of Norco:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Dry eye syndrome treatments and more:

COVID vaccines that are related to Dry eye syndrome:

All the drugs that are associated with Dry eye syndrome:

All the conditions that are associated with Dry eye syndrome:

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Norco) and Norco (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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