Norco and Dupuytren's contracture - a phase IV clinical study of FDA data

• Norco (65,779 reports)

• Abasia (inability to walk): 162 reports
• Abdominal discomfort: 720 reports
• Abdominal distension: 461 reports
• Abdominal pain: 1,099 reports
• Abdominal pain upper: 844 reports
• Abnormal behavior: 124 reports
• Abnormal dreams: 152 reports
• Accidental overdose (therapeutic agent): 651 reports
• Acne (skin problems that cause pimples): 110 reports
• Activities of daily living impaired: 161 reports
• Acute kidney failure: 957 reports
• Acute myocardial infarction (acute heart attack): 129 reports
• Acute respiratory failure: 150 reports
• Adverse drug reaction: 261 reports
• Adverse event: 209 reports
• Aggression: 115 reports
• Agitation (state of anxiety or nervous excitement): 309 reports
• Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 265 reports
• Alanine aminotransferase increased: 151 reports
• Anaemia (lack of blood): 967 reports
• Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 151 reports
• Anger: 131 reports
• Anhedonia (inability to experience pleasure from activities usually found enjoyable): 299 reports
• Ankle fracture: 196 reports
• Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 1,139 reports
• Appetite - increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 143 reports
• Arrhythmias (irregular heartbeat): 382 reports
• Arthritis (form of joint disorder that involves inflammation of one or more joints): 501 reports
• Arthropathy: 277 reports
• Ascites (accumulation of fluid in the abdominal cavity): 113 reports
• Aspartate aminotransferase increased: 160 reports
• Asthma: 301 reports
• Atelectasis (partial or complete collapse of the lung): 177 reports
• Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 470 reports
• Back disorder: 164 reports
• Back injury: 133 reports
• Back pain: 1,816 reports
• Balance disorder: 462 reports
• Bleeding disorders: 109 reports
• Blindness: 109 reports
• Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 265 reports
• Blood alkaline phosphatase increased: 102 reports
• Blood creatinine increased: 227 reports
• Blood glucose decreased: 105 reports
• Blood glucose increased: 400 reports
• Blood potassium decreased: 248 reports
• Blood pressure management: 103 reports
• Blood sodium decreased: 108 reports
• Bone disorder: 237 reports
• Bone pain: 393 reports
• Bradycardia (abnormally slow heart action): 124 reports
• Breathing difficulty: 2,389 reports
• Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 559 reports
• Burning sensation: 325 reports
• Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder): 127 reports
• Cardiac arrest: 172 reports
• Cardiac disorder: 289 reports
• Cardiac failure: 160 reports
• Cardiac failure congestive: 579 reports
• Cardio-respiratory arrest (sudden dysfunction of heart and lungs): 143 reports
• Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling): 131 reports
• Cataract (clouding of the lens inside the eye): 272 reports
• Cellulitis (infection under the skin): 433 reports
• Chest pain: 1,341 reports
• Chills (felling of cold): 517 reports
• Chronic kidney disease: 994 reports
• Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe): 424 reports
• Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving): 245 reports
• Colitis (inflammation of colon): 123 reports
• Compression fracture (fracture due to pressure caused by injury): 101 reports
• Confusion: 136 reports
• Confusional state: 863 reports
• Consciousness - decreased: 110 reports
• Constipation: 1,444 reports
• Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 214 reports
• Coronary heart disease (narrowing or blockage of the coronary arteries): 212 reports
• Cough: 921 reports
• Coughing up blood: 168 reports
• Crohn's disease (condition that causes inflammation of the gastrointestinal tract): 222 reports
• Crying: 318 reports
• Death: 11,100 reports
• Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 542 reports
• Deformity (disfigurement): 102 reports
• Dehydration (dryness resulting from the removal of water): 917 reports
• Dental caries: 122 reports
• Dependence: 190 reports
• Depressed mood: 167 reports
• Depression: 1,863 reports
• Diabetes: 292 reports
• Diarrhea: 2,625 reports
• Disability: 287 reports
• Discomfort: 147 reports
• Disease progression: 396 reports
• Disturbance in attention: 247 reports
• Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 173 reports
• Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body): 108 reports
• Dizziness: 2,030 reports
• Drowsiness: 1,034 reports
• Drug abuse and dependence: 1,543 reports
• Drug dependence: 3,710 reports
• Drug diversion: 312 reports
• Drug effect decreased: 267 reports
• Drug hypersensitivity: 782 reports
• Drug ineffective: 2,944 reports
• Drug intolerance (drug sensitivity): 285 reports
• Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 790 reports
• Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother): 1,073 reports
• Dry eyes (lack of adequate tears): 132 reports
• Dry mouth: 391 reports
• Dry skin: 304 reports
• Dyskinesia (abnormality or impairment of voluntary movement): 120 reports
• Dyspnea exertional: 222 reports
• Dysstasia (difficulty in standing): 133 reports
• Ear pain: 173 reports
• Eating disorder: 114 reports
• Emotional distress: 841 reports
• Enlarged heart: 137 reports
• Erection problems: 101 reports
• Exostosis (formation of new bone on the surface of a bone): 141 reports
• Eye disorder: 127 reports
• Eye pain: 146 reports
• Faeces discolored: 104 reports
• Fainting (loss of consciousness and postural tone): 411 reports
• Fall: 2,114 reports
• Fatigue (feeling of tiredness): 3,646 reports
• Fear: 139 reports
• Febrile neutropenia (fever with reduced white blood cells): 129 reports
• Feeling cold: 114 reports
• Feeling hot: 203 reports
• Femur fracture: 120 reports
• Fever: 1,013 reports
• Fibromyalgia (a long-term condition which causes pain all over the body): 332 reports
• Flatulence (flatus expelled through the anus): 234 reports
• Fluid overload (too much fluid in the blood): 137 reports
• Fluid retention (an abnormal accumulation of fluid in the blood): 310 reports
• Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 759 reports
• Foot fracture: 151 reports
• Full blood count decreased: 135 reports
• Fungal infection: 125 reports
• Gait disturbance: 1,020 reports
• Gallbladder disorder: 106 reports
• Gallstones (stone formation by bile component): 204 reports
• Gastric disorder (disease of stomach): 163 reports
• Gastric ulcer (stomach ulcer): 249 reports
• Gastritis (inflammation of stomach): 192 reports
• Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 517 reports
• Gastrointestinal disorder (functional problems of gastrointestinal tract): 246 reports
• Gastrointestinal haemorrhage (bleeding gastrointestinal tract): 634 reports
• General physical health deterioration (weak health status): 285 reports
• Gout (uric acid crystals building up in the body): 143 reports
• Haematochezia (passage of stools containing blood): 142 reports
• Haematocrit decreased: 145 reports
• Haematoma (collection of blood outside the blood vessels): 110 reports
• Haematuria (presence of blood in urine): 196 reports
• Haemoglobin decreased: 503 reports
• Haemorrhage (bleeding): 305 reports
• Haemorrhoids (a swollen vein or group of veins in the region of the anus): 163 reports
• Hair color changes: 143 reports
• Hair disorder: 105 reports
• Hair loss: 747 reports
• Hallucinations (sensations that appear real but are created by your mind): 365 reports
• Headache (pain in head): 2,471 reports
• Head injury: 816 reports
• Hearing loss: 153 reports
• Heart attack: 508 reports
• Heart palpitations (feelings or sensations that your heart is pounding or racing): 438 reports
• Heart rate decreased: 108 reports
• Heart rate increased: 347 reports
• Heart rate irregular: 135 reports
• Hepatic enzyme increased: 171 reports
• Hepatic steatosis (fatty liver disease): 119 reports
• Hepatitis c: 200 reports
• Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle): 146 reports
• Herpes zoster: 260 reports
• Hiatal hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 218 reports
• High blood cholesterol: 284 reports
• High blood pressure: 1,657 reports
• Hip fracture: 204 reports
• Hoarseness or changing voice: 229 reports
• Hospitalisation: 364 reports
• Hot flush (sudden feelings of heat): 333 reports
• Hyperglycemia (high blood sugar): 110 reports
• Hyperhidrosis (abnormally increased sweating): 640 reports
• Hyperkalemia (damage to or disease of the kidney): 214 reports
• Hyperlipidaemia (presence of excess lipids in the blood): 169 reports
• Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary): 106 reports
• Hypersensitivity: 535 reports
• Hypoacusis (loss of hearing): 134 reports
• Hypoaesthesia (reduced sense of touch or sensation): 939 reports
• Hypoglycemia (low blood sugar): 126 reports
• Hypokalemia (low potassium): 285 reports
• Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 203 reports
• Hypophagia (reduced food intake): 156 reports
• Hypotension (abnormally low blood pressure): 890 reports
• Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 180 reports
• Ill-defined disorder: 102 reports
• Impaired healing: 206 reports
• Indigestion: 498 reports
• Infection: 485 reports
• Inflammation: 103 reports
• Influenza like illness: 321 reports
• Infusion related reaction: 122 reports
• Injection site bruising: 131 reports
• Injection site erythema (redness at injection site): 180 reports
• Injection site pain: 398 reports
• Injury: 634 reports
• Insomnia (sleeplessness): 1,546 reports
• International normalised ratio increased: 102 reports
• Intervertebral disc degeneration (spinal disc degeneration): 320 reports
• Intervertebral disc disorder (spinal disc disorder): 110 reports
• Intervertebral disc protrusion (spinal disc protrusion): 377 reports
• Intestinal obstruction: 211 reports
• Irritability: 233 reports
• Irritable bowel syndrome: 150 reports
• Itching: 880 reports
• Joint injury: 196 reports
• Joint pain: 1,756 reports
• Joint stiffness: 159 reports
• Joint swelling: 530 reports
• Kidney infection: 122 reports
• Kidney stones: 339 reports
• Knee joint replacement: 116 reports
• Leukocytosis (increased white blood cells): 126 reports
• Leukopenia (less number of white blood cells in blood): 113 reports
• Limb discomfort (discomfort in leg): 123 reports
• Limb injury: 221 reports
• Live birth: 133 reports
• Liver disorder (liver diseases): 103 reports
• Localised infection (infection at the single location): 146 reports
• Loss of consciousness: 555 reports
• Lower limb fracture: 127 reports
• Low tissue oxygen: 145 reports
• Lung disorder (lung disease): 121 reports
• Lymph follicular hypertrophy (an increase in the size of the lymph node follicles): 193 reports
• Malaise (a feeling of general discomfort or uneasiness): 1,786 reports
• Malignant neoplasm progression (cancer tumour came back): 344 reports
• Malnutrition (condition that results from eating a diet in which certain nutrients are lacking): 119 reports
• Maternal exposure during pregnancy (use of substance during pregnancy): 570 reports
• Memory loss: 1,176 reports
• Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 307 reports
• Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition): 127 reports
• Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 257 reports
• Metastases to bone (cancer spreads to bone): 172 reports
• Migraine (headache): 697 reports
• Mitral valve incompetence (inefficient heart valve): 110 reports
• Mobility decreased (ability to move is reduced): 230 reports
• Mood swings (an extreme or rapid change in mood): 227 reports
• Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 106 reports
• Multiple myeloma (cancer of the plasma cells): 251 reports
• Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 115 reports
• Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 302 reports
• Muscle aches (muscle pain): 697 reports
• Muscle spasms (muscle contraction): 1,020 reports
• Muscle strain (an injury to a muscle in which the muscle fibres tear): 123 reports
• Muscle twitching: 103 reports
• Musculoskeletal chest pain (pain in chest muscle or nerve or bones): 112 reports
• Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 395 reports
• Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 351 reports
• Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 197 reports
• Nasopharyngitis (inflammation of the nasopharynx): 607 reports
• Nausea (feeling of having an urge to vomit): 3,619 reports
• Nausea and vomiting: 1,997 reports
• Neck pain: 464 reports
• Neoplasm malignant (cancer tumour): 198 reports
• Neoplasm progression (growth of tumour): 137 reports
• Nephrogenic anaemia (anaemia due to kidney disease): 183 reports
• Nerve compression: 121 reports
• Nerve injury: 155 reports
• Nervousness: 302 reports
• Nervous system disorder (a general class of medical conditions affecting the nervous system): 104 reports
• Neuralgia (pain in one or more nerves): 246 reports
• Neuropathy peripheral (surface nerve damage): 622 reports
• Nightmares (unpleasant dreams): 126 reports
• Night sweats (sweating in night): 236 reports
• Nosebleed (bleeding from nose): 421 reports
• Oedema (fluid collection in tissue): 390 reports
• Oedema peripheral (superficial swelling): 766 reports
• Oral pain: 246 reports
• Oropharyngeal pain: 350 reports
• Osteoarthritis (a joint disease caused by cartilage loss in a joint): 566 reports
• Osteomyelitis (infection of bone): 207 reports
• Osteonecrosis of jaw (death of bone of jaw): 283 reports
• Osteopenia (a condition where bone mineral density is lower than normal): 194 reports
• Osteoporosis (bones weak and more likely to break): 322 reports
• Otitis (ear infection): 123 reports
• Overdose: 5,025 reports
• Oxygen saturation decreased: 139 reports
• Pain: 4,160 reports
• Pain in extremity: 1,746 reports
• Pain in jaw: 253 reports
• Pancreatitis (inflammation of pancreas): 201 reports
• Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 227 reports
• Panic disorder: 267 reports
• Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 728 reports
• Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur): 114 reports
• Peripheral swelling: 809 reports
• Photophobia (extreme sensitivity to light): 111 reports
• Pleural effusion (water on the lungs): 375 reports
• Pneumonia: 1,745 reports
• Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 191 reports
• Post procedural complication: 104 reports
• Post-traumatic stress disorder: 106 reports
• Pre-existing condition improved: 279 reports
• Procedural pain: 105 reports
• Productive cough: 190 reports
• Pruritus generalised (generalized itching): 108 reports
• Psoriasis (immune-mediated disease that affects the skin): 192 reports
• Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 110 reports
• Psychological trauma: 106 reports
• Psychotic disorder: 106 reports
• Pulmonary embolism (blockage of the main artery of the lung): 597 reports
• Pulmonary hypertension (increase in blood pressure in the lung artery): 136 reports
• Pulmonary oedema (fluid accumulation in the lungs): 210 reports
• Rashes (redness): 1,569 reports
• Rash pruritic (redness with itching): 142 reports
• Rectal haemorrhage (bleeding from anus): 271 reports
• Red blood cell count decreased: 182 reports
• Renal disorder (kidney disease): 169 reports
• Renal failure acute (rapid kidney dysfunction): 195 reports
• Renal failure chronic (long lasting kidney dysfunction): 107 reports
• Renal impairment (severely reduced kidney function): 231 reports
• Renal injury (kidney injury): 306 reports
• Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 369 reports
• Restless leg syndrome (a powerful urge to move your legs): 147 reports
• Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints): 360 reports
• Rib fracture: 196 reports
• Rickets (softening of bones): 125 reports
• Road traffic accident: 408 reports
• Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder): 157 reports
• Scar: 153 reports
• Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 162 reports
• Scoliosis (a medical condition in which a person's spine is curved from side to side): 125 reports
• Seasonal allergy (allergic condition due to certain season): 108 reports
• Sedation: 106 reports
• Seizures (abnormal excessive or synchronous neuronal activity in the brain): 415 reports
• Sepsis (a severe blood infection that can lead to organ failure and death): 546 reports
• Septic shock (shock due to blood infection): 146 reports
• Sinus disorder (disease of sinus): 150 reports
• Sinusitis (inflammation of sinus): 735 reports
• Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 109 reports
• Skin blushing/flushing (a sudden reddening of the face, neck): 240 reports
• Skin discoloration: 212 reports
• Skin disorder (skin disease): 174 reports
• Skin exfoliation (removal of the oldest dead skin cells): 165 reports
• Skin ulcer: 109 reports
• Sleep apnea syndrome: 377 reports
• Sleep disorder: 275 reports
• Small intestinal obstruction (blockage in small intestine): 113 reports
• Sneezing: 106 reports
• Speech disorder: 183 reports
• Speech impairment (adult) (inability to speak (adult)): 294 reports
• Spinal fracture (fracture in one of vertebrae): 118 reports
• Spinal osteoarthritis (joint cartilage loss in spine): 244 reports
• Splenomegaly (enlargement of spleen): 101 reports
• Staphylococcal infection (an infection with staphylococcus bacteria): 225 reports
• Stomatitis (inflammation of mucous membrane of mouth): 326 reports
• Stress and anxiety: 2,345 reports
• Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 521 reports
• Suicidal ideation: 533 reports
• Suicide attempt: 166 reports
• Surgery: 351 reports
• Swallowing difficulty: 461 reports
• Swelling: 434 reports
• Swelling face: 222 reports
• Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 101 reports
• Taste - impaired: 308 reports
• Tenderness (pain or discomfort when an affected area is touched): 115 reports
• The flu (the flu is caused by an influenza virus): 484 reports
• Therapeutic response decreased (less preventive response): 158 reports
• Therapeutic response unexpected: 320 reports
• Throat irritation: 128 reports
• Thrombocytopenia (decrease of platelets in blood): 698 reports
• Thrombosis (formation of a blood clot inside a blood vessel): 357 reports
• Thyroid diseases: 113 reports
• Tinnitus (a ringing in the ears): 217 reports
• Tooth abscess (pus formation in tooth): 234 reports
• Toothaches (tooth pain): 173 reports
• Tooth disorder (tooth disease): 161 reports
• Tooth extraction: 104 reports
• Tooth fracture: 102 reports
• Tooth loss: 164 reports
• Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 174 reports
• Tremor (trembling or shaking movements in one or more parts of your body): 883 reports
• Tumor: 114 reports
• Unresponsive to stimuli: 141 reports
• Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding): 131 reports
• Upper limb fracture: 126 reports
• Upper respiratory tract infection: 262 reports
• Urinary incontinence (inability to control the flow of urine and involuntary urination): 199 reports
• Urinary retention (the inability to completely or partially empty the bladder): 134 reports
• Urinary tract infection: 1,127 reports
• Urination - painful: 195 reports
• Urticaria (rash of round, red welts on the skin that itch intensely): 287 reports
• Vaginal bleeding: 150 reports
• Viral infection: 156 reports
• Vision blurred: 561 reports
• Visual acuity reduced (reduced clearness of vision): 106 reports
• Visual impairment: 391 reports
• Weakness: 2,289 reports
• Weight decreased: 1,494 reports
• Weight increased: 977 reports
• Weight loss: 146 reports
• Wheezing (a high-pitched whistling sound made while you breath): 224 reports
• White blood cell count decreased: 449 reports
• White blood cell count increased: 220 reports
• Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 398 reports
• Wound: 127 reports

• Dupuytren's contracture (2,031 reports)

All the drugs that are associated with Dupuytren's contracture:

• Dupuytren's contracture (445 drugs)

All the conditions that are associated with Dupuytren's contracture:

• Dupuytren's contracture (208 conditions)

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