Norflex and Ear buzzing - a phase IV clinical study of FDA data


Ear buzzing is found among people who take Norflex, especially for people who are female, 40-49 old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Norflex and have Ear buzzing. It is created by eHealthMe based on reports of 1,569 people who have side effects when taking Norflex from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Jul, 13, 2022

1,569 people reported to have side effects when taking Norflex.
Among them, 28 people (1.78%) have Ear buzzing.

What is Norflex?

Norflex has active ingredients of orphenadrine citrate. It is often used in muscle spasms. eHealthMe is studying from 1,832 Norflex users for its effectiveness, alternative drugs and more.

What is Ear buzzing?

Ear buzzing is found to be associated with 3,200 drugs and 2,875 conditions by eHealthMe.

Number of Norflex and Ear buzzing reports submitted per year:

Could Norflex cause Ear buzzing?

Time on Norflex when people have Ear buzzing *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Ear buzzing when taking Norflex *:

  • female: 67.86 %
  • male: 32.14 %

Age of people who have Ear buzzing when taking Norflex *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 3.7 %
  • 30-39: 7.41 %
  • 40-49: 77.78 %
  • 50-59: 11.11 %
  • 60+: 0.0 %

Common drugs people take besides Norflex *:

  1. Toradol: 17 people, 60.71%
  2. Tranxene: 13 people, 46.43%
  3. Vioxx: 8 people, 28.57%
  4. Inderal: 7 people, 25.00%
  5. Albuterol: 6 people, 21.43%
  6. Neurontin: 6 people, 21.43%
  7. Allegra: 6 people, 21.43%
  8. Relafen: 6 people, 21.43%
  9. Sudafed 12 Hour: 6 people, 21.43%
  10. Seroquel: 5 people, 17.86%

Common side effects people have besides Ear buzzing *:

  1. Chest Pain: 21 people, 75.00%
  2. Nausea (feeling of having an urge to vomit): 19 people, 67.86%
  3. Breathing Difficulty: 19 people, 67.86%
  4. Dizziness: 17 people, 60.71%
  5. Difficulty In Walking: 16 people, 57.14%
  6. Constipation: 16 people, 57.14%
  7. Hypoaesthesia (reduced sense of touch or sensation): 15 people, 53.57%
  8. Injection Site Pain: 14 people, 50.00%
  9. Nervousness: 14 people, 50.00%
  10. Faecal Incontinence (a lack of control over passing stool): 14 people, 50.00%

Common conditions people have *:

  1. Neck Pain: 10 people, 35.71%
  2. Pain: 5 people, 17.86%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 17.86%
  4. Drowsiness: 4 people, 14.29%
  5. Seasonal Allergy (allergic condition due to certain season): 2 people, 7.14%
  6. Neuralgia (pain in one or more nerves): 2 people, 7.14%
  7. Muscle Tightness: 2 people, 7.14%
  8. Migraine (headache): 2 people, 7.14%
  9. Hyperchlorhydria (gastric acid levels are higher in stomach): 2 people, 7.14%
  10. High Blood Pressure: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Norflex and have Ear buzzing?

Check whether Ear buzzing is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Ear buzzing and when was it recovered:

Expand to all the drugs that have ingredients of orphenadrine citrate:

Alternative drugs to, pros and cons of Norflex:

Common Norflex side effects:

Browse all side effects of Norflex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Ear buzzing treatments and more:

COVID vaccines that are related to Ear buzzing:

Common drugs associated with Ear buzzing:

All the drugs that are associated with Ear buzzing:

Common conditions associated with Ear buzzing:

All the conditions that are associated with Ear buzzing:

How the study uses the data?

The study uses data from the FDA. It is based on orphenadrine citrate (the active ingredients of Norflex) and Norflex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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