Norflex and Water retention - a phase IV clinical study of FDA data


Water retention is reported only by a few people who take Norflex.

The phase IV clinical study analyzes which people take Norflex and have Water retention. It is created by eHealthMe based on reports of 1,569 people who have side effects while taking Norflex from the FDA, and is updated regularly.

With medical big data and AI algorithms, eHealthMe enables everyone to run phase IV clinical trial to detect adverse drug outcomes and monitor effectiveness. Our original studies have been referenced on 600+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Most recently, phase IV clinial trails for COVID 19 vaccines have been added, check here.

On Jul, 16, 2022

1,569 people reported to have side effects when taking Norflex.
Among them, 5 people (0.32%) have Water retention.

What is Norflex?

Norflex has active ingredients of orphenadrine citrate. It is often used in muscle spasms. eHealthMe is studying from 1,758 Norflex users for its effectiveness, alternative drugs and more.

What is Water retention?

Water retention is found to be associated with 2,975 drugs and 2,206 conditions by eHealthMe.

Number of Norflex and Water retention reports submitted per year:

Could Norflex cause Water retention?

Gender of people who have Water retention when taking Norflex *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Water retention when taking Norflex *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 25 %
  • 40-49: 25 %
  • 50-59: 0.0 %
  • 60+: 50 %

Common drugs people take besides Norflex *:

  1. Aspirin: 4 people, 80.00%
  2. Zofran: 3 people, 60.00%
  3. Miralax: 3 people, 60.00%
  4. Prilosec: 3 people, 60.00%
  5. Protonix: 3 people, 60.00%
  6. Albuterol: 2 people, 40.00%
  7. Singulair: 2 people, 40.00%
  8. Lisinopril: 2 people, 40.00%
  9. Furosemide: 2 people, 40.00%
  10. Forteo: 2 people, 40.00%

Common side effects people have besides Water retention *:

  1. Oedema Peripheral (superficial swelling): 4 people, 80.00%
  2. Hypersensitivity: 3 people, 60.00%
  3. Vision Blurred: 3 people, 60.00%
  4. Weight Decreased: 3 people, 60.00%
  5. Nausea And Vomiting: 3 people, 60.00%
  6. Chest Pain: 3 people, 60.00%
  7. Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 2 people, 40.00%
  8. Pain In Extremity: 2 people, 40.00%
  9. Headache (pain in head): 2 people, 40.00%
  10. Depression: 2 people, 40.00%

Common conditions people have *:

  1. Osteoporosis (bones weak and more likely to break): 2 people, 40.00%
  2. Nausea (feeling of having an urge to vomit): 2 people, 40.00%
  3. Constipation: 2 people, 40.00%
  4. Pulmonary Congestion (congestion in the lungs): 1 person, 20.00%
  5. Impaired Gastric Emptying: 1 person, 20.00%
  6. Cough: 1 person, 20.00%
  7. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 20.00%

* Approximation only. Some reports may have incomplete information.

Do you take Norflex and have Water retention?

Check whether Water retention is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Alternative drugs to, pros and cons of Norflex:

Water retention treatments and more:

COVID vaccines that are related to Water retention:

How severe was Water retention and when was it recovered:

Expand to all the drugs that have ingredients of orphenadrine citrate:

Common drugs associated with Water retention:

All the drugs that are associated with Water retention:

Common conditions associated with Water retention:

All the conditions that are associated with Water retention:

How the study uses the data?

The study uses data from the FDA. It is based on orphenadrine citrate (the active ingredients of Norflex) and Norflex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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