Omeprazole and Hyperchloraemia - a phase IV clinical study of FDA data


We study 380,957 people who have side effects when taking Omeprazole. Hyperchloraemia is found, especially among people who are female, 60+ old, also take Morphine and have Burkitt lymphoma.

The phase IV clinical study analyzes which people take Omeprazole and have Hyperchloraemia. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 02, 2023

380,957 people reported to have side effects when taking Omeprazole.
Among them, 16 people (0.0%) have Hyperchloraemia.

What is Omeprazole?

Omeprazole has active ingredients of omeprazole. It is used in gastroesophageal reflux disease. Currently, eHealthMe is studying from 390,286 Omeprazole users.

What is Hyperchloraemia?

Hyperchloraemia (an excess of chlorides in the blood) is found to be associated with 406 drugs and 164 conditions by eHealthMe. Currently, we are studying 869 people who have Hyperchloraemia.

Number of Omeprazole and Hyperchloraemia reports submitted per year:

Could Omeprazole cause Hyperchloraemia?

Gender of people who have Hyperchloraemia when taking Omeprazole *:

  • female: 81.25 %
  • male: 18.75 %

Age of people who have Hyperchloraemia when taking Omeprazole *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 6.25 %
  • 40-49: 25.0 %
  • 50-59: 0.0 %
  • 60+: 68.75 %

Common drugs people take besides Omeprazole *:

  1. Morphine: 4 people, 25.00%
  2. Vancomycin: 3 people, 18.75%
  3. Sodium Bicarbonate: 3 people, 18.75%
  4. Cordarone: 2 people, 12.50%
  5. Paracetamol: 2 people, 12.50%
  6. Bromhexine Hydrochloride: 2 people, 12.50%
  7. Panthenol: 2 people, 12.50%
  8. Clexane: 2 people, 12.50%
  9. Zocor: 1 person, 6.25%
  10. Clarithromycin: 1 person, 6.25%

Common side effects people have besides Hyperchloraemia *:

  1. Hyperventilation: 8 people, 50.00%
  2. Blood Bicarbonate Decreased: 7 people, 43.75%
  3. Blood Creatinine Increased: 6 people, 37.50%
  4. Tracheal Obstruction (blockage of trachea): 4 people, 25.00%
  5. Acidosis Hyperchloraemic (increased acidity in the blood and other body tissue with decrease in plasma bicarbonate concentration): 4 people, 25.00%
  6. Increased Viscosity Of Bronchial Secretion: 4 people, 25.00%
  7. Hypernatraemia (an abnormally high plasma concentration of sodium ions): 4 people, 25.00%
  8. Blood Sodium Decreased: 4 people, 25.00%
  9. Hyperkalemia (damage to or disease of the kidney): 3 people, 18.75%
  10. Hypotension (abnormally low blood pressure): 3 people, 18.75%

Common conditions people have *:

  1. Klebsiella Infection: 2 people, 12.50%
  2. Diabetes: 2 people, 12.50%
  3. Burkitt Lymphoma (cancer of the lymphatic system): 2 people, 12.50%
  4. Urinary Tract Infection: 1 person, 6.25%
  5. Stenotrophomonas Infection: 1 person, 6.25%
  6. Staphylococcal Infection (an infection with staphylococcus bacteria): 1 person, 6.25%
  7. Serratia Infection (bacterial infection): 1 person, 6.25%
  8. Proteus Infection (proteus can cause urinary tract infections): 1 person, 6.25%
  9. Pneumonia: 1 person, 6.25%
  10. Pain: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Omeprazole and have Hyperchloraemia?

Check whether Hyperchloraemia is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Omeprazole side effects by duration, gender and age:

Hyperchloraemia treatments and more:

All the drugs that are associated with Hyperchloraemia:

All the conditions that are associated with Hyperchloraemia:

How the study uses the data?

The study uses data from the FDA. It is based on omeprazole (the active ingredients of Omeprazole) and Omeprazole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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