Ortho tri-cyclen and Neutropenia aggravated - a phase IV clinical study of FDA data


We study 4,839 people who have side effects when taking Ortho tri-cyclen. Neutropenia aggravated is found, especially among people who are female, 20-29 old, have been taking the drug for 2 - 5 years, also take Accutane and have Acne cystic.

The phase IV clinical study analyzes which people take Ortho tri-cyclen and have Neutropenia aggravated. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 24, 2023

4,839 people reported to have side effects when taking Ortho tri-cyclen.
Among them, 28 people (0.58%) have Neutropenia aggravated.

What is Ortho tri-cyclen?

Ortho tri-cyclen has active ingredients of ethinyl estradiol; norgestimate. It is used in birth control. Currently, eHealthMe is studying from 5,698 Ortho tri-cyclen users.

What is Neutropenia aggravated?

Neutropenia aggravated (worse an abnormally low number of neutrophils) is found to be associated with 1,686 drugs and 532 conditions by eHealthMe. Currently, we are studying 86 people who have Neutropenia aggravated.

Number of Ortho tri-cyclen and Neutropenia aggravated reports submitted per year:

Could Ortho tri-cyclen cause Neutropenia aggravated?

Time on Ortho tri-cyclen when people have Neutropenia aggravated *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 100 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Neutropenia aggravated when taking Ortho tri-cyclen *:

  • female: 92.86 %
  • male: 7.14 %

Age of people who have Neutropenia aggravated when taking Ortho tri-cyclen *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 4 %
  • 20-29: 64 %
  • 30-39: 16 %
  • 40-49: 8 %
  • 50-59: 0.0 %
  • 60+: 8 %

Common drugs people take besides Ortho tri-cyclen *:

  1. Accutane: 23 people, 82.14%
  2. Ursodiol: 1 person, 3.57%
  3. Tri-Sprintec: 1 person, 3.57%
  4. Synthroid: 1 person, 3.57%
  5. Sutent: 1 person, 3.57%
  6. Rebetol: 1 person, 3.57%
  7. Lisinopril: 1 person, 3.57%
  8. Levofloxacin: 1 person, 3.57%
  9. Lansoprazole: 1 person, 3.57%
  10. Ganciclovir: 1 person, 3.57%

Common side effects people have besides Neutropenia aggravated *:

  1. Stress And Anxiety: 23 people, 82.14%
  2. Back Pain: 23 people, 82.14%
  3. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 23 people, 82.14%
  4. Depression: 23 people, 82.14%
  5. Irritable Bowel Syndrome: 23 people, 82.14%
  6. Inflammatory Bowel Disease: 23 people, 82.14%
  7. Mitral Valve Prolapse (heart's mitral valve doesn't work well): 22 people, 78.57%
  8. Mitral Valve Incompetence (inefficient heart valve): 22 people, 78.57%
  9. Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder): 22 people, 78.57%
  10. Ventricular Extrasystoles (premature cardiac contraction): 22 people, 78.57%

Common conditions people have *:

  1. Acne Cystic (skin problems that cause pimples): 6 people, 21.43%
  2. Schizoaffective Disorder (a mental disorder characterized by disordered thought): 1 person, 3.57%
  3. Renal Cell Carcinoma (a kidney cancer): 1 person, 3.57%
  4. Pneumonia Cytomegaloviral (cmv pneumonia is caused by a member of a group of herpes-type viruses): 1 person, 3.57%
  5. Metastases To Lung (cancer spreads to lung): 1 person, 3.57%
  6. Hepatitis C: 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Ortho tri-cyclen and have Neutropenia aggravated?

Check whether Neutropenia aggravated is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Ortho tri-cyclen side effects by duration, gender and age:

Neutropenia aggravated treatments and more:

Common drugs associated with Neutropenia aggravated:

All the drugs that are associated with Neutropenia aggravated:

Common conditions associated with Neutropenia aggravated:

All the conditions that are associated with Neutropenia aggravated:

How the study uses the data?

The study uses data from the FDA. It is based on ethinyl estradiol; norgestimate (the active ingredients of Ortho tri-cyclen) and Ortho tri-cyclen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


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DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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