Oxaliplatin and Sick sinus syndrome - a phase IV clinical study of FDA data

• Oxaliplatin (50,569 reports)

• Abdominal discomfort: 115 reports
• Abdominal distension: 268 reports
• Abdominal pain: 1,720 reports
• Abdominal pain upper: 473 reports
• Abscess (pus): 109 reports
• Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood): 164 reports
• Acute kidney failure: 607 reports
• Acute myocardial infarction (acute heart attack): 207 reports
• Agitation (state of anxiety or nervous excitement): 170 reports
• Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 3,490 reports
• Alanine aminotransferase increased: 326 reports
• Altered state of consciousness (altered state of mind): 125 reports
• Anaemia (lack of blood): 1,939 reports
• Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 582 reports
• Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight): 142 reports
• Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 1,725 reports
• Ards (acute respiratory distress syndrome) (sudden failure of the respiratory (breathing) system): 261 reports
• Arrhythmias (irregular heartbeat): 632 reports
• Arteriospasm coronary (spasm of the large- or medium-sized coronary arteries): 351 reports
• Ascites (accumulation of fluid in the abdominal cavity): 572 reports
• Aspartate aminotransferase increased: 321 reports
• Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 483 reports
• Back pain: 478 reports
• Bleeding disorders: 114 reports
• Blood alkaline phosphatase increased: 210 reports
• Blood bilirubin increased: 275 reports
• Blood creatinine increased: 309 reports
• Blood glucose increased: 126 reports
• Blood lactate dehydrogenase increased: 145 reports
• Blood potassium decreased: 138 reports
• Body temperature increased: 124 reports
• Bone marrow failure: 761 reports
• Bone pain: 135 reports
• Bradycardia (abnormally slow heart action): 140 reports
• Breathing difficulty: 2,322 reports
• Breathing sounds - abnormal (stridor): 126 reports
• Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 348 reports
• Carcinoembryonic antigen increased: 117 reports
• Cardiac arrest: 407 reports
• Cardiac disorder: 104 reports
• Cardiac failure: 269 reports
• Cardiogenic shock (inadequate circulation of blood): 105 reports
• Cardiomyopathy (weakening of the heart muscle): 103 reports
• Cardio-respiratory arrest (sudden dysfunction of heart and lungs): 227 reports
• Cardiotoxicity (damage to the heart muscle): 268 reports
• Cellulitis (infection under the skin): 117 reports
• Cerebral infarction (less blood supply to brain resulting tissue damage): 135 reports
• Chest pain: 986 reports
• Chills (felling of cold): 845 reports
• Cholangitis (infection of the bile duct): 181 reports
• Cholecystitis (infection of gallbladder): 112 reports
• Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 188 reports
• Circulatory collapse: 157 reports
• Colitis (inflammation of colon): 333 reports
• Colon cancer: 319 reports
• Colon cancer metastatic (cancer of colon spreads to other part of body): 120 reports
• Colorectal cancer metastatic (cancer of colon and rectal spreads to other parts): 152 reports
• Confusion: 108 reports
• Confusional state: 341 reports
• Conjunctivitis (pink eye): 117 reports
• Consciousness - decreased: 178 reports
• Constipation: 784 reports
• Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 113 reports
• Cough: 408 reports
• C-reactive protein increased: 190 reports
• Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions): 203 reports
• Death: 2,073 reports
• Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 505 reports
• Dehydration (dryness resulting from the removal of water): 1,644 reports
• Depressed level of consciousness: 170 reports
• Depression: 136 reports
• Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis): 637 reports
• Device related infection: 179 reports
• Diarrhea: 5,718 reports
• Disease progression: 2,046 reports
• Disease recurrence: 154 reports
• Disseminated intravascular coagulation (systemic activation of blood coagulation): 288 reports
• Dizziness: 755 reports
• Drowsiness: 176 reports
• Drug hypersensitivity: 226 reports
• Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications): 115 reports
• Drug ineffective: 724 reports
• Drug intolerance (drug sensitivity): 222 reports
• Drug resistance (reduction in effectiveness of a drug): 101 reports
• Dry mouth: 128 reports
• Dry skin: 312 reports
• Dysaesthesia (abnormal sensation): 135 reports
• Dyspnea exertional: 152 reports
• Ejection fraction decreased (systolic heart failure): 118 reports
• Embolism (obstruction of an artery, typically by a clot of blood or an air bubble): 191 reports
• Encephalopathy (functioning of the brain is affected by some agent or condition): 199 reports
• Enteritis (inflammation of the small intestine): 245 reports
• Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon): 128 reports
• Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 105 reports
• Fainting (loss of consciousness and postural tone): 345 reports
• Fall: 322 reports
• Fatigue (feeling of tiredness): 2,379 reports
• Febrile neutropenia (fever with reduced white blood cells): 1,274 reports
• Feeling hot: 255 reports
• Fever: 2,504 reports
• Fistula (an abnormal connection or passageway between two): 103 reports
• Flatulence (flatus expelled through the anus): 114 reports
• Gait disturbance: 227 reports
• Gamma-glutamyltransferase increased: 156 reports
• Gastric ulcer (stomach ulcer): 261 reports
• Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 148 reports
• Gastrointestinal disorder (functional problems of gastrointestinal tract): 328 reports
• Gastrointestinal haemorrhage (bleeding gastrointestinal tract): 332 reports
• Gastrointestinal perforation (hole in the digestive tract): 650 reports
• Gastrointestinal toxicity (damage to digestive tract by any substance): 312 reports
• General physical health deterioration (weak health status): 1,013 reports
• Haematemesis (vomiting of blood): 226 reports
• Haematochezia (passage of stools containing blood): 113 reports
• Haematocrit decreased: 104 reports
• Haematotoxicity (toxins that destroy red blood cells): 435 reports
• Haematuria (presence of blood in urine): 240 reports
• Haemoglobin decreased: 514 reports
• Haemolytic anaemia (anaemia due to haemolysis): 176 reports
• Haemorrhage (bleeding): 336 reports
• Hair loss: 388 reports
• Headache (pain in head): 429 reports
• Heart attack: 349 reports
• Heart palpitations (feelings or sensations that your heart is pounding or racing): 155 reports
• Heart rate increased: 143 reports
• Hemiparesis (weakness on one side of the body): 131 reports
• Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure): 147 reports
• Hepatic enzyme increased: 127 reports
• Hepatic failure (liver failure): 370 reports
• Hepatic steatosis (fatty liver disease): 132 reports
• Hepatitis (inflammation of the liver): 108 reports
• Hepatocellular injury (liver injury): 179 reports
• Hepatotoxicity (chemical-driven liver damage): 213 reports
• Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough): 136 reports
• High blood pressure: 1,590 reports
• Hoarseness or changing voice: 317 reports
• Hot flush (sudden feelings of heat): 116 reports
• Hyperammonaemia: 228 reports
• Hyperammonaemic encephalopathy (excess of ammonia in the blood, disorder or disease of the brain): 147 reports
• Hyperbilirubinaemia (excess of bilirubin in the blood): 192 reports
• Hypercalcaemia (elevated calcium (ca+) level in the blood): 101 reports
• Hyperglycemia (high blood sugar): 206 reports
• Hyperhidrosis (abnormally increased sweating): 528 reports
• Hyperkalemia (damage to or disease of the kidney): 187 reports
• Hypersensitivity: 936 reports
• Hypertensive crisis: 180 reports
• Hypertransaminasaemia: 102 reports
• Hypoaesthesia (reduced sense of touch or sensation): 480 reports
• Hypoalbuminaemia (levels of albumin in blood serum are abnormally low): 203 reports
• Hypocalcaemia (levels of calcium in blood serum are abnormally low): 158 reports
• Hypokalemia (low potassium): 862 reports
• Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 470 reports
• Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 364 reports
• Hypophagia (reduced food intake): 143 reports
• Hypotension (abnormally low blood pressure): 1,227 reports
• Idiopathic pulmonary fibrosis (chronic lung disease): 222 reports
• Ill-defined disorder: 121 reports
• Impaired healing: 135 reports
• Indigestion: 206 reports
• Infection: 570 reports
• Infusion related reaction: 582 reports
• Insomnia (sleeplessness): 175 reports
• Interstitial lung disease: 881 reports
• Intestinal ischaemia (decreased supply of oxygenated blood to the intestines): 117 reports
• Intestinal obstruction: 815 reports
• Itching: 782 reports
• Jaundice - yellow skin (a yellowish pigmentation of the skin): 284 reports
• Joint pain: 213 reports
• Large intestine perforation (hole in large intestine): 214 reports
• Laryngospasm (an uncontrolled/involuntary muscular contraction of larynx): 343 reports
• Leukocytosis (increased white blood cells): 137 reports
• Leukoencephalopathy (disease of the white matter in the brain): 124 reports
• Leukopenia (less number of white blood cells in blood): 1,092 reports
• Liver disorder (liver diseases): 162 reports
• Liver injury: 138 reports
• Loss of consciousness: 501 reports
• Low tissue oxygen: 118 reports
• Lung disorder (lung disease): 195 reports
• Lymph follicular hypertrophy (an increase in the size of the lymph node follicles): 119 reports
• Malaise (a feeling of general discomfort or uneasiness): 1,056 reports
• Malignant neoplasm progression (cancer tumour came back): 1,071 reports
• Melaena (the passage of black, tarry stools): 102 reports
• Memory loss: 122 reports
• Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 150 reports
• Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 168 reports
• Metastases to liver (cancer spreads to liver): 625 reports
• Metastases to lung (cancer spreads to lung): 321 reports
• Metastases to lymph nodes (cancer spreads to lymph node): 149 reports
• Metastases to peritoneum (cancer spreads to peritoneum): 138 reports
• Mucosal inflammation (infection of mucous membrane): 1,199 reports
• Multi-organ failure (multisystem organ failure): 210 reports
• Muscle aches (muscle pain): 156 reports
• Muscle spasms (muscle contraction): 365 reports
• Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 143 reports
• Myelosuppression (a decrease in the production of blood cells): 157 reports
• Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 129 reports
• Nausea (feeling of having an urge to vomit): 4,055 reports
• Nausea and vomiting: 3,572 reports
• Neoplasm malignant (cancer tumour): 128 reports
• Neoplasm progression (growth of tumour): 341 reports
• Neuropathy peripheral (surface nerve damage): 2,757 reports
• Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system): 1,107 reports
• Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection): 234 reports
• Neutrophil count decreased (less than normal number of neutrophil a type of blood cell): 622 reports
• Non-hodgkin's lymphoma (malignant (cancer) cells form in the lymph system): 118 reports
• Nosebleed (bleeding from nose): 473 reports
• Oedema (fluid collection in tissue): 155 reports
• Oedema peripheral (superficial swelling): 429 reports
• Oesophagitis (inflammation of oesophagus): 193 reports
• Oxygen saturation decreased: 413 reports
• Pain: 755 reports
• Pain in extremity: 300 reports
• Paleness (unusual lightness of skin colour): 131 reports
• Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome): 1,241 reports
• Pancreatitis (inflammation of pancreas): 118 reports
• Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 385 reports
• Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 1,302 reports
• Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect): 134 reports
• Paronychia (infection in the tissues adjacent to a nail on a finger or toe): 387 reports
• Peripheral sensory neuropathy (damage to one or more of your peripheral nerves): 550 reports
• Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 288 reports
• Pleural effusion (water on the lungs): 448 reports
• Pneumonia: 1,167 reports
• Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 132 reports
• Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung): 116 reports
• Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 432 reports
• Portal hypertension (increase in the blood pressure within a system of veins called the portal venous system): 208 reports
• Posterior reversible encephalopathy syndrome (posterior reversible encephalopathy syndrome (pres), also known as reversible posterior leukoencephalopathy syndrome (rpls), is a syndrome characterized by headache, confusion, seizures and visual loss): 183 reports
• Protein - urine: 479 reports
• Pulmonary embolism (blockage of the main artery of the lung): 907 reports
• Pulmonary oedema (fluid accumulation in the lungs): 148 reports
• Rashes (redness): 2,073 reports
• Rectal haemorrhage (bleeding from anus): 196 reports
• Renal failure acute (rapid kidney dysfunction): 413 reports
• Renal impairment (severely reduced kidney function): 314 reports
• Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 590 reports
• Respiratory distress (difficulty in breathing): 200 reports
• Seizures (abnormal excessive or synchronous neuronal activity in the brain): 149 reports
• Sepsis (a severe blood infection that can lead to organ failure and death): 1,026 reports
• Septic shock (shock due to blood infection): 508 reports
• Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin): 203 reports
• Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 103 reports
• Skin blushing/flushing (a sudden reddening of the face, neck): 463 reports
• Skin discoloration - bluish (bluish colour of skin): 127 reports
• Skin disorder (skin disease): 170 reports
• Skin exfoliation (removal of the oldest dead skin cells): 158 reports
• Skin fissures (a crack in the skin): 112 reports
• Skin reaction: 161 reports
• Skin toxicity (skin damage due to toxin/poison): 429 reports
• Small intestinal obstruction (blockage in small intestine): 228 reports
• Speech disorder: 228 reports
• Speech impairment (adult) (inability to speak (adult)): 504 reports
• Splenomegaly (enlargement of spleen): 239 reports
• Stable angina (a constant chest pain): 191 reports
• Staphylococcal infection (an infection with staphylococcus bacteria): 106 reports
• Stomatitis (inflammation of mucous membrane of mouth): 1,101 reports
• Stress and anxiety: 214 reports
• Stress cardiomyopathy (stress-induced chronic disease of the heart muscle): 110 reports
• Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 319 reports
• Subileus: 110 reports
• Swallowing difficulty: 447 reports
• Taste - impaired: 292 reports
• Therapeutic response decreased (less preventive response): 132 reports
• Throat tightness: 281 reports
• Thrombocytopenia (decrease of platelets in blood): 3,548 reports
• Thrombosis (formation of a blood clot inside a blood vessel): 244 reports
• Transaminases increased: 134 reports
• Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 154 reports
• Tremor (trembling or shaking movements in one or more parts of your body): 440 reports
• Tumor lysis syndrome: 173 reports
• Unilateral hydronephrosis (kidney stone that causes obstruction of the ureter): 128 reports
• Urinary retention (the inability to completely or partially empty the bladder): 117 reports
• Urinary tract infection: 451 reports
• Urticaria (rash of round, red welts on the skin that itch intensely): 204 reports
• Venoocclusive liver disease (small veins in the liver are obstructed): 456 reports
• Ventricular fibrillation (abnormally irregular heart rhythm): 141 reports
• Vision blurred: 166 reports
• Weakness: 2,046 reports
• Weight decreased: 804 reports
• Weight increased: 128 reports
• Wheezing (a high-pitched whistling sound made while you breath): 131 reports
• White blood cell count decreased: 698 reports
• White blood cell count increased: 132 reports

• Sick sinus syndrome (4,111 reports)

• Allopurinol: 127 reports
• Amlodipine: 145 reports
• Aricept: 107 reports
• Aspirin: 502 reports
• Atenolol: 189 reports
• Avandia: 232 reports
• Coumadin: 231 reports
• Digoxin: 306 reports
• Diovan: 119 reports
• Fosamax: 159 reports
• Furosemide: 268 reports
• Lasix: 291 reports
• Lipitor: 197 reports
• Lisinopril: 188 reports
• Metformin: 177 reports
• Nexium: 101 reports
• Norvasc: 169 reports
• Omeprazole: 119 reports
• Plavix: 150 reports
• Prednisone: 132 reports
• Prilosec: 106 reports
• Simvastatin: 153 reports
• Spironolactone: 108 reports
• Synthroid: 134 reports
• Toprol-xl: 102 reports
• Vioxx: 236 reports
• Warfarin sodium: 104 reports
• Zocor: 103 reports

All the drugs that are associated with Sick sinus syndrome:

• Sick sinus syndrome (1,242 drugs)

• A-fib: 297 reports
• Atrial fibrillation: 307 reports
• Atrial fibrillation/flutter: 297 reports
• Atrial flutter: 297 reports
• Auricular fibrillation: 297 reports
• Blood pressure increased: 427 reports
• Diabetes: 216 reports
• Diabetes mellitus: 217 reports
• Hbp: 427 reports
• High blood pressure: 427 reports
• Hypertension: 431 reports
• Multiple myeloma: 149 reports
• Osteoporosis: 152 reports
• Ra: 103 reports
• Rheumatoid arthritis: 103 reports
• Rheumatoid arthritis aggravated: 103 reports
• Thin bones: 140 reports
• Type 2 diabetes: 121 reports
• Type 2 diabetes mellitus: 121 reports

All the conditions that are associated with Sick sinus syndrome:

• Sick sinus syndrome (710 conditions)

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