Oxcarbazepine and Hepatocellular injury - a phase IV clinical study of FDA data

• Oxcarbazepine (11,198 reports)

• Abdominal pain: 104 reports
• Abnormal behavior: 117 reports
• Abortion spontaneous (naturally occurring miscarriage): 146 reports
• Acute kidney failure: 132 reports
• Aggression: 223 reports
• Agitation (state of anxiety or nervous excitement): 186 reports
• Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 110 reports
• Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat): 149 reports
• Arrhythmias (irregular heartbeat): 141 reports
• Back pain: 103 reports
• Balance disorder: 195 reports
• Breathing difficulty: 196 reports
• Cardiac arrest: 114 reports
• Chest pain: 146 reports
• Completed suicide (act of taking one's own life): 399 reports
• Confusional state: 218 reports
• Constipation: 127 reports
• Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 549 reports
• Cough: 103 reports
• Death: 144 reports
• Depression: 304 reports
• Diarrhea: 265 reports
• Diplopia (double vision): 154 reports
• Disturbance in attention: 105 reports
• Dizziness: 568 reports
• Drowsiness: 433 reports
• Drug hypersensitivity: 138 reports
• Drug ineffective: 1,124 reports
• Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 287 reports
• Erythema multiforme (a type of hypersensitivity reaction): 106 reports
• Fall: 433 reports
• Fatigue (feeling of tiredness): 547 reports
• Fever: 333 reports
• Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 117 reports
• Gait disturbance: 223 reports
• Headache (pain in head): 438 reports
• Head injury: 112 reports
• High blood pressure: 212 reports
• Hypoaesthesia (reduced sense of touch or sensation): 102 reports
• Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 398 reports
• Hypotension (abnormally low blood pressure): 138 reports
• Insomnia (sleeplessness): 244 reports
• Irritability: 109 reports
• Itching: 147 reports
• Joint pain: 152 reports
• Loss of consciousness: 146 reports
• Malaise (a feeling of general discomfort or uneasiness): 224 reports
• Maternal exposure during pregnancy (use of substance during pregnancy): 146 reports
• Memory loss: 268 reports
• Movement - uncoordinated: 128 reports
• Muscle spasms (muscle contraction): 129 reports
• Nausea (feeling of having an urge to vomit): 367 reports
• Nausea and vomiting: 369 reports
• Overdose: 151 reports
• Pain: 315 reports
• Pain in extremity: 165 reports
• Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 132 reports
• Pneumonia: 128 reports
• Psychotic disorder: 120 reports
• Rashes (redness): 396 reports
• Seizures (abnormal excessive or synchronous neuronal activity in the brain): 880 reports
• Speech disorder: 118 reports
• Speech impairment (adult) (inability to speak (adult)): 140 reports
• Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 163 reports
• Stress and anxiety: 339 reports
• Suicidal ideation: 174 reports
• Suicide attempt: 103 reports
• Thrombocytopenia (decrease of platelets in blood): 104 reports
• Tremor (trembling or shaking movements in one or more parts of your body): 238 reports
• Urinary tract infection: 128 reports
• Weakness: 331 reports
• Weight decreased: 182 reports
• Weight increased: 241 reports

• Hepatocellular injury (14,296 reports)

• Acetaminophen: 128 reports
• Aldactone: 122 reports
• Allopurinol: 339 reports
• Alprazolam: 302 reports
• Amlodipine: 315 reports
• Amoxicillin: 341 reports
• Aspirin: 220 reports
• Atarax: 142 reports
• Atenolol: 105 reports
• Atorvastatin calcium: 135 reports
• Augmentin: 458 reports
• Bactrim: 678 reports
• Carboplatin: 169 reports
• Cefotaxime: 140 reports
• Ceftriaxone: 248 reports
• Cellcept: 128 reports
• Clarithromycin: 120 reports
• Cordarone: 191 reports
• Crestor: 276 reports
• Cyclophosphamide: 227 reports
• Cymbalta: 146 reports
• Cytarabine: 216 reports
• Dexamethasone: 126 reports
• Diazepam: 138 reports
• Eliquis: 167 reports
• Emend: 154 reports
• Escitalopram: 146 reports
• Etoposide: 112 reports
• Flagyl: 137 reports
• Fluconazole: 109 reports
• Furosemide: 439 reports
• Gaviscon: 119 reports
• Gilenya: 122 reports
• Hydrochlorothiazide: 125 reports
• Ibuprofen: 206 reports
• Innohep: 199 reports
• Irbesartan: 126 reports
• Isentress: 133 reports
• Kaletra: 141 reports
• Keppra: 274 reports
• Keytruda: 108 reports
• Lamictal: 167 reports
• Lansoprazole: 432 reports
• Lantus: 154 reports
• Levetiracetam: 184 reports
• Lovenox: 605 reports
• Lyrica: 399 reports
• Metformin: 392 reports
• Methotrexate: 849 reports
• Methotrexate sodium: 101 reports
• Metronidazole: 113 reports
• Mirtazapine: 119 reports
• Morphine: 227 reports
• Movicol: 147 reports
• Neurontin: 101 reports
• Nexium: 189 reports
• Norvir: 207 reports
• Novorapid: 123 reports
• Olanzapine: 193 reports
• Omeprazole: 351 reports
• Ondansetron: 132 reports
• Opdivo: 114 reports
• Oxaliplatin: 179 reports
• Oxycontin: 139 reports
• Paclitaxel: 137 reports
• Pantoprazole: 625 reports
• Paracetamol: 1,978 reports
• Paroxetine: 188 reports
• Plaquenil: 113 reports
• Plavix: 153 reports
• Polaramine: 120 reports
• Prednisolone: 224 reports
• Prednisone: 369 reports
• Prezista: 148 reports
• Ramipril: 313 reports
• Risperidone: 130 reports
• Sertraline: 155 reports
• Simvastatin: 192 reports
• Solu-medrol: 182 reports
• Spironolactone: 107 reports
• Tacrolimus: 123 reports
• Tegretol: 112 reports
• Tramadol: 450 reports
• Tramadol hydrochloride: 116 reports
• Truvada: 184 reports
• Valium: 134 reports
• Xanax: 222 reports
• Xarelto: 127 reports
• Zolpidem: 139 reports
• Zopiclone: 214 reports

All the drugs that are associated with Hepatocellular injury:

• Hepatocellular injury (958 drugs)

• Acute lymphoblastic anemia: 352 reports
• Acute lymphocytic leukemia (all): 355 reports
• A-fib: 325 reports
• Ankylosing spondylitis: 120 reports
• Anxiety: 348 reports
• Atrial fibrillation: 339 reports
• Atrial fibrillation/flutter: 339 reports
• Bipolar disorder: 103 reports
• Blood pressure - high: 1,000 reports
• Blood triglycerides increased: 356 reports
• Breast cancer: 240 reports
• Breast cancer metastatic: 126 reports
• Cardiac failure: 107 reports
• Cystitis: 134 reports
• Depression: 713 reports
• Diabetes: 179 reports
• Diabetes - type 2: 301 reports
• Dyslipidemia: 367 reports
• Epilepsy: 345 reports
• Feeling uptight: 348 reports
• Gastroesophageal reflux disease: 167 reports
• High blood cholesterol: 340 reports
• High blood pressure: 951 reports
• Hiv: 362 reports
• Hiv infection: 374 reports
• Human immunodeficiency virus infection: 362 reports
• Hypercholesterolaemia: 340 reports
• Hypertension: 951 reports
• Hypertension aggravated: 1,040 reports
• Infection: 445 reports
• Insomnia: 180 reports
• Lipid profile: 111 reports
• Lipid test: 367 reports
• Low thyroid: 199 reports
• Lung adenocarcinoma: 128 reports
• Lung disorder: 160 reports
• Metastatic malignant melanoma: 110 reports
• Multiple sclerosis: 202 reports
• Nausea and vomiting: 115 reports
• Neuralgia: 111 reports
• Pain: 1,165 reports
• Pain management: 1,084 reports
• Preventive health care: 173 reports
• Reflux esophagitis: 174 reports
• Rheumatoid arthritis: 304 reports
• Spondylitis: 120 reports
• Tuberculosis: 106 reports

All the conditions that are associated with Hepatocellular injury:

• Hepatocellular injury (882 conditions)

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