Palonosetron and Heart attack - a phase IV clinical study of FDA data


We study 5,389 people who have side effects when taking Palonosetron. Heart attack is found, especially among people who are male, 60+ old, have been taking the drug for < 1 month, also take Dexamethasone and have Lung cancer - non-small cell.

The phase IV clinical study analyzes which people take Palonosetron and have Heart attack. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 03, 2023

5,389 people reported to have side effects when taking Palonosetron.
Among them, 17 people (0.32%) have Heart attack.

What is Palonosetron?

Palonosetron has active ingredients of palonosetron hydrochloride. Currently, eHealthMe is studying from 5,401 Palonosetron users.

What is Heart attack?

Heart attack is found to be associated with 3,584 drugs and 3,207 conditions by eHealthMe. Currently, we are studying 260,389 people who have Heart attack.

Number of Palonosetron and Heart attack reports submitted per year:

Could Palonosetron cause Heart attack?

Time on Palonosetron when people have Heart attack *:

  • < 1 month: 75 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 25 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Heart attack when taking Palonosetron *:

  • female: 37.5 %
  • male: 62.5 %

Age of people who have Heart attack when taking Palonosetron *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 6.67 %
  • 60+: 93.33 %

Common drugs people take besides Palonosetron *:

  1. Niacin: 7 people, 41.18%
  2. Dexamethasone: 7 people, 41.18%
  3. Folic Acid: 6 people, 35.29%
  4. Prochlorperazine: 6 people, 35.29%
  5. Zofran: 5 people, 29.41%
  6. Cisplatin: 5 people, 29.41%
  7. Glyburide: 5 people, 29.41%
  8. Prevacid: 5 people, 29.41%
  9. Mirtazapine: 5 people, 29.41%
  10. Allopurinol: 5 people, 29.41%

Common side effects people have besides Heart attack *:

  1. High Blood Pressure: 2 people, 11.76%
  2. Nasopharyngitis (inflammation of the nasopharynx): 2 people, 11.76%
  3. Bladder Cancer: 2 people, 11.76%
  4. Cardiac Arrest: 2 people, 11.76%
  5. Upper-Airway Cough Syndrome: 2 people, 11.76%
  6. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 11.76%
  7. Cardiac Failure: 1 person, 5.88%
  8. Arteriosclerosis Coronary Artery (thickening and hardening of arteries- coronary artery): 1 person, 5.88%
  9. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 5.88%
  10. Bundle Branch Block Left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle): 1 person, 5.88%

Common conditions people have *:

  1. Lung Cancer - Non-Small Cell (lung cancer): 6 people, 35.29%
  2. Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 3 people, 17.65%
  3. Depression: 2 people, 11.76%
  4. Muscle Aches (muscle pain): 2 people, 11.76%
  5. High Blood Cholesterol: 2 people, 11.76%
  6. Gout (uric acid crystals building up in the body): 2 people, 11.76%
  7. Diabetes: 2 people, 11.76%
  8. Bladder Cancer: 2 people, 11.76%
  9. Burkitt Lymphoma (cancer of the lymphatic system): 2 people, 11.76%
  10. Blood Potassium Decreased: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Palonosetron and have Heart attack?

Check whether Heart attack is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Palonosetron side effects by duration, gender and age:

Heart attack treatments and more:

Common drugs associated with Heart attack:

All the drugs that are associated with Heart attack:

Common conditions associated with Heart attack:

All the conditions that are associated with Heart attack:

How the study uses the data?

The study uses data from the FDA. It is based on palonosetron hydrochloride (the active ingredients of Palonosetron) and Palonosetron (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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