Pantoprazole and Megacolon - a phase IV clinical study of FDA data


Megacolon is found among people who take Pantoprazole, especially for people who are female, 40-49 old.

The phase IV clinical study analyzes which people take Pantoprazole and have Megacolon. It is created by eHealthMe based on reports of 219,443 people who have side effects when taking Pantoprazole from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Nov, 30, 2022

219,443 people reported to have side effects when taking Pantoprazole.
Among them, 98 people (0.04%) have Megacolon.

What is Pantoprazole?

Pantoprazole has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 222,376 Pantoprazole users for its effectiveness, alternative drugs and more.

What is Megacolon?

Megacolon (a very dilated colon) is found to be associated with 737 drugs and 376 conditions by eHealthMe.

Number of Pantoprazole and Megacolon reports submitted per year:

Could Pantoprazole cause Megacolon?

Gender of people who have Megacolon when taking Pantoprazole *:

  • female: 80 %
  • male: 20 %

Age of people who have Megacolon when taking Pantoprazole *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 1.25 %
  • 30-39: 30.0 %
  • 40-49: 38.75 %
  • 50-59: 8.75 %
  • 60+: 21.25 %

Common drugs people take besides Pantoprazole *:

  1. Sulfamethoxazole: 15 people, 15.31%
  2. Mitoxantrone: 13 people, 13.27%
  3. Rydapt: 13 people, 13.27%
  4. Paracetamol: 11 people, 11.22%
  5. Fluvastatin: 9 people, 9.18%
  6. Vancomycin: 9 people, 9.18%
  7. Insulin: 7 people, 7.14%
  8. Cosentyx: 7 people, 7.14%
  9. Lasix: 6 people, 6.12%
  10. Amoxicillin And Clavulanate Potassium: 5 people, 5.10%

Common side effects people have besides Megacolon *:

  1. Drug Ineffective: 43 people, 43.88%
  2. Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 38 people, 38.78%
  3. Pseudomembranous Colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon): 30 people, 30.61%
  4. Gastrointestinal Perforation (hole in the digestive tract): 30 people, 30.61%
  5. Trimethylaminuria (trimethylamine builds up in the body of patients with trimethylaminuria. the trimethylamine gets released in the person's sweat, urine, reproductive fluids, and breath, giving off a strong fishy or body odour): 29 people, 29.59%
  6. Fever: 25 people, 25.51%
  7. Sepsis (a severe blood infection that can lead to organ failure and death): 23 people, 23.47%
  8. Diarrhea: 23 people, 23.47%
  9. Abdominal Pain Upper: 22 people, 22.45%
  10. Bacterial Test Positive: 21 people, 21.43%

Common conditions people have *:

  1. Bipolar Disorder (mood disorder): 43 people, 43.88%
  2. Urinary Tract Infection: 22 people, 22.45%
  3. Bacterial Infection: 18 people, 18.37%
  4. Diarrhea: 18 people, 18.37%
  5. Bacterial Test Positive: 15 people, 15.31%
  6. Abdominal Pain: 15 people, 15.31%
  7. Reflux Gastritis (a condition in which the lining of a person's stomach becomes inflamed as a result of exposure to bile): 14 people, 14.29%
  8. Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 13 people, 13.27%
  9. Bacteriuria (presence of bacteria in urine): 12 people, 12.24%
  10. Leukocytosis (increased white blood cells): 11 people, 11.22%

* Approximation only. Some reports may have incomplete information.

Do you take Pantoprazole and have Megacolon?

Check whether Megacolon is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Megacolon and when was it recovered:

Expand to all the drugs that have ingredients of pantoprazole sodium:

Alternative drugs to, pros and cons of Pantoprazole:

Common Pantoprazole side effects:

Browse all side effects of Pantoprazole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Megacolon treatments and more:

COVID vaccines that are related to Megacolon:

Common drugs associated with Megacolon:

All the drugs that are associated with Megacolon:

All the conditions that are associated with Megacolon:

How the study uses the data?

The study uses data from the FDA. It is based on pantoprazole sodium (the active ingredients of Pantoprazole) and Pantoprazole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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