Paroxetine and Hepatitis fulminant - a phase IV clinical study of FDA data


Hepatitis fulminant is found among people who take Paroxetine, especially for people who are female, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Paroxetine and have Hepatitis fulminant. It is created by eHealthMe based on reports of 56,969 people who have side effects when taking Paroxetine from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 26, 2022

56,969 people reported to have side effects when taking Paroxetine.
Among them, 39 people (0.07%) have Hepatitis fulminant.

What is Paroxetine?

Paroxetine has active ingredients of paroxetine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 58,167 Paroxetine users for its effectiveness, alternative drugs and more.

What is Hepatitis fulminant?

Hepatitis fulminant (life-threatening condition defined by significantly impaired liver function) is found to be associated with 927 drugs and 635 conditions by eHealthMe.

Number of Paroxetine and Hepatitis fulminant reports submitted per year:

Could Paroxetine cause Hepatitis fulminant?

Time on Paroxetine when people have Hepatitis fulminant *:

  • < 1 month: 71.43 %
  • 1 - 6 months: 14.29 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 14.29 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Hepatitis fulminant when taking Paroxetine *:

  • female: 68.42 %
  • male: 31.58 %

Age of people who have Hepatitis fulminant when taking Paroxetine *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 10.53 %
  • 40-49: 15.79 %
  • 50-59: 21.05 %
  • 60+: 52.63 %

Common drugs people take besides Paroxetine *:

  1. Xanax: 8 people, 20.51%
  2. Allopurinol: 5 people, 12.82%
  3. Omeprazole: 5 people, 12.82%
  4. Actonel: 4 people, 10.26%
  5. Calcitriol: 4 people, 10.26%
  6. Prednisolone: 4 people, 10.26%
  7. Gliclazide: 3 people, 7.69%
  8. Metformin: 3 people, 7.69%
  9. Xarelto: 3 people, 7.69%
  10. Levothyroxine Sodium: 3 people, 7.69%

Common side effects people have besides Hepatitis fulminant *:

  1. Multi-Organ Failure (multisystem organ failure): 6 people, 15.38%
  2. Thrombocytopenia (decrease of platelets in blood): 5 people, 12.82%
  3. Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 4 people, 10.26%
  4. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 4 people, 10.26%
  5. Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 4 people, 10.26%
  6. Coma Hepatic (accumulation in the bloodstream of toxic substances that are normally removed by the liver leads coma): 4 people, 10.26%
  7. Hepatic Failure (liver failure): 4 people, 10.26%
  8. Ventricular Fibrillation (abnormally irregular heart rhythm): 4 people, 10.26%
  9. Acute Kidney Failure: 4 people, 10.26%
  10. Renal Failure Acute (rapid kidney dysfunction): 4 people, 10.26%

Common conditions people have *:

  1. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 10.26%
  2. Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 3 people, 7.69%
  3. Heart Disease: 3 people, 7.69%
  4. Diabetic Nephropathy (diabetic kidney disease): 3 people, 7.69%
  5. Depression: 3 people, 7.69%
  6. Suicide Attempt: 2 people, 5.13%
  7. Stupor (lack of critical cognitive function and level of consciousness): 1 person, 2.56%
  8. Quit Smoking: 1 person, 2.56%
  9. Panic Disorder: 1 person, 2.56%
  10. Lymphoma (cancer that begins in immune system cells): 1 person, 2.56%

* Approximation only. Some reports may have incomplete information.

Do you take Paroxetine and have Hepatitis fulminant?

Check whether Hepatitis fulminant is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

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How severe was Hepatitis fulminant and when was it recovered:

Expand to all the drugs that have ingredients of paroxetine hydrochloride:

Alternative drugs to, pros and cons of Paroxetine:

Common Paroxetine side effects:

Browse all side effects of Paroxetine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Hepatitis fulminant treatments and more:

COVID vaccines that are related to Hepatitis fulminant:

Common drugs associated with Hepatitis fulminant:

All the drugs that are associated with Hepatitis fulminant:

Common conditions associated with Hepatitis fulminant:

All the conditions that are associated with Hepatitis fulminant:

How the study uses the data?

The study uses data from the FDA. It is based on paroxetine hydrochloride (the active ingredients of Paroxetine) and Paroxetine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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