Paxil and Facial paralysis - a phase IV clinical study of FDA data


Facial paralysis is found among people who take Paxil, especially for people who are female, 40-49 old, have been taking the drug for 1 - 2 years.

The phase IV clinical study analyzes which people take Paxil and have Facial paralysis. It is created by eHealthMe based on reports of 87,385 people who have side effects when taking Paxil from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 29, 2022

87,385 people reported to have side effects when taking Paxil.
Among them, 17 people (0.02%) have Facial paralysis.

What is Paxil?

Paxil has active ingredients of paroxetine hydrochloride. It is often used in depression. eHealthMe is studying from 91,143 Paxil users for its effectiveness, alternative drugs and more.

What is Facial paralysis?

Facial paralysis (loss of function of face muscle) is found to be associated with 1,537 drugs and 927 conditions by eHealthMe.

Number of Paxil and Facial paralysis reports submitted per year:

Could Paxil cause Facial paralysis?

Time on Paxil when people have Facial paralysis *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 83.33 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 16.67 %

Gender of people who have Facial paralysis when taking Paxil *:

  • female: 53.33 %
  • male: 46.67 %

Age of people who have Facial paralysis when taking Paxil *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 7.69 %
  • 20-29: 0.0 %
  • 30-39: 15.38 %
  • 40-49: 53.85 %
  • 50-59: 15.38 %
  • 60+: 7.69 %

Common drugs people take besides Paxil *:

  1. Estraderm: 5 people, 29.41%
  2. Tylenol: 2 people, 11.76%
  3. Benadryl: 2 people, 11.76%
  4. Dilantin: 2 people, 11.76%
  5. Lamictal: 2 people, 11.76%
  6. Seroquel: 2 people, 11.76%
  7. Risperdal: 2 people, 11.76%
  8. Gravol: 2 people, 11.76%
  9. Zantac: 1 person, 5.88%
  10. Glycolax: 1 person, 5.88%

Common side effects people have besides Facial paralysis *:

  1. Speech Impairment (Adult) (inability to speak (adult)): 10 people, 58.82%
  2. Fatigue (feeling of tiredness): 9 people, 52.94%
  3. Memory Loss: 7 people, 41.18%
  4. Headache (pain in head): 7 people, 41.18%
  5. Nausea (feeling of having an urge to vomit): 7 people, 41.18%
  6. Dizziness: 7 people, 41.18%
  7. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 7 people, 41.18%
  8. Dissociation: 6 people, 35.29%
  9. Migraine (headache): 6 people, 35.29%
  10. Mood Swings (an extreme or rapid change in mood): 6 people, 35.29%

Common conditions people have *:

  1. Migraine (headache): 5 people, 29.41%
  2. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 11.76%
  3. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.88%
  4. Psoriasis (immune-mediated disease that affects the skin): 1 person, 5.88%
  5. Premenstrual Dysphoric Disorder: 1 person, 5.88%
  6. Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 1 person, 5.88%
  7. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.88%
  8. Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 1 person, 5.88%
  9. Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 5.88%
  10. High Blood Pressure: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Paxil and have Facial paralysis?

Check whether Facial paralysis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

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How severe was Facial paralysis and when was it recovered:

Expand to all the drugs that have ingredients of paroxetine hydrochloride:

Alternative drugs to, pros and cons of Paxil:

Common Paxil side effects:

Browse all side effects of Paxil:

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Facial paralysis treatments and more:

COVID vaccines that are related to Facial paralysis:

Common drugs associated with Facial paralysis:

All the drugs that are associated with Facial paralysis:

Common conditions associated with Facial paralysis:

All the conditions that are associated with Facial paralysis:

How the study uses the data?

The study uses data from the FDA. It is based on paroxetine hydrochloride (the active ingredients of Paxil) and Paxil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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