Paxil and Major depression - from FDA reports


Major depression is found among people who take Paxil, especially for people who are female, 40-49 old , have been taking the drug for 2 - 5 years, also take medication Seroquel, and have Pain. This review analyzes which people have Major depression with Paxil. It is created by eHealthMe based on reports of 78,781 people who have side effects when taking Paxil from FDA, and is updated regularly.



On Jul, 13, 2018

78,781 people reported to have side effects when taking Paxil.
Among them, 235 people (0.3%) have Major depression


Number of reports submitted per year:

Could Paxil cause Major depression?

Time on Paxil when people have Major depression *:

  • < 1 month: 13.21 %
  • 1 - 6 months: 15.09 %
  • 6 - 12 months: 9.43 %
  • 1 - 2 years: 15.09 %
  • 2 - 5 years: 32.08 %
  • 5 - 10 years: 13.21 %
  • 10+ years: 1.89 %

Gender of people who have Major depression when taking Paxil *:

  • female: 56.6 %
  • male: 43.4 %

Age of people who have Major depression when taking Paxil *:

  • 0-1: 0.52 %
  • 2-9: 0.0 %
  • 10-19: 8.81 %
  • 20-29: 3.11 %
  • 30-39: 13.99 %
  • 40-49: 32.12 %
  • 50-59: 25.39 %
  • 60+: 16.06 %

Top conditions involved for these people *:

  1. Insomnia (sleeplessness): 25 people, 10.64%
  2. Pain: 25 people, 10.64%
  3. Sleep Disorder: 19 people, 8.09%
  4. Bipolar Disorder (mood disorder): 17 people, 7.23%
  5. Parkinson's Disease: 13 people, 5.53%

Top co-used drugs for these people *:

  1. Seroquel: 76 people, 32.34%
  2. Effexor: 44 people, 18.72%
  3. Zyprexa: 41 people, 17.45%
  4. Xanax: 38 people, 16.17%
  5. Lexapro: 38 people, 16.17%

Top other side effects for these people *:

  1. Suicidal Ideation: 107 people, 45.53%
  2. Headache (pain in head): 65 people, 27.66%
  3. Dizziness: 64 people, 27.23%
  4. Suicide Attempt: 59 people, 25.11%
  5. Fatigue (feeling of tiredness): 56 people, 23.83%

* Approximation only. Some reports may have incomplete information.

What's next:

You could also:



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Paxil has active ingredients of paroxetine hydrochloride. It is often used in depression. (latest outcomes from Paxil 82,159 users)

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

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