Pepcid and Aortic valve replacement - a phase IV clinical study of FDA data


Aortic valve replacement is found among people who take Pepcid, especially for people who are male, 60+ old.

The phase IV clinical study analyzes which people take Pepcid and have Aortic valve replacement. It is created by eHealthMe based on reports of 48,403 people who have side effects when taking Pepcid from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 03, 2023

48,403 people reported to have side effects when taking Pepcid.
Among them, 12 people (0.02%) have Aortic valve replacement.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 49,526 Pepcid users for its effectiveness, alternative drugs and more.

What is Aortic valve replacement?

Aortic valve replacement is found to be associated with 636 drugs and 279 conditions by eHealthMe.

Number of Pepcid and Aortic valve replacement reports submitted per year:

Could Pepcid cause Aortic valve replacement?

Gender of people who have Aortic valve replacement when taking Pepcid *:

  • female: 25 %
  • male: 75 %

Age of people who have Aortic valve replacement when taking Pepcid *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 10 %
  • 60+: 90 %

Common drugs people take besides Pepcid *:

  1. Lasix: 9 people, 75.00%
  2. Colace: 8 people, 66.67%
  3. Carvedilol: 6 people, 50.00%
  4. Prednisone: 6 people, 50.00%
  5. Cytoxan: 6 people, 50.00%
  6. Celexa: 6 people, 50.00%
  7. Lisinopril: 6 people, 50.00%
  8. Zometa: 6 people, 50.00%
  9. Aredia: 6 people, 50.00%
  10. Amoxicillin: 6 people, 50.00%

Common side effects people have besides Aortic valve replacement *:

  1. Breathing Difficulty: 8 people, 66.67%
  2. Infection: 8 people, 66.67%
  3. Fall: 8 people, 66.67%
  4. Cardiac Valve Disease (heart valve disease): 8 people, 66.67%
  5. Anaemia (lack of blood): 8 people, 66.67%
  6. Aortic Stenosis (obstruction to the outflow of blood from the left ventricle into the aorta): 8 people, 66.67%
  7. Neuropathy Peripheral (surface nerve damage): 6 people, 50.00%
  8. Musculoskeletal Discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves): 6 people, 50.00%
  9. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 50.00%
  10. Pain: 6 people, 50.00%

Common conditions people have *:

  1. Hyperkalemia (damage to or disease of the kidney): 2 people, 16.67%
  2. Skin Blushing/flushing (a sudden reddening of the face, neck): 1 person, 8.33%
  3. Hypersensitivity: 1 person, 8.33%
  4. High Blood Cholesterol: 1 person, 8.33%
  5. Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 8.33%
  6. Fabry's Disease (build up of a particular type of fat, called globotriaosylceramide, in the body's cells): 1 person, 8.33%
  7. Asthma: 1 person, 8.33%
  8. Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Pepcid and have Aortic valve replacement?

Check whether Aortic valve replacement is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Aortic valve replacement and when was it recovered:

Expand to all the drugs that have ingredients of famotidine:

Alternative drugs to, pros and cons of Pepcid:

Common Pepcid side effects:

Browse all side effects of Pepcid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Aortic valve replacement treatments and more:

COVID vaccines that are related to Aortic valve replacement:

Common drugs associated with Aortic valve replacement:

All the drugs that are associated with Aortic valve replacement:

Common conditions associated with Aortic valve replacement:

All the conditions that are associated with Aortic valve replacement:

How the study uses the data?

The study uses data from the FDA. It is based on famotidine (the active ingredients of Pepcid) and Pepcid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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