Percocet and Epidermal necrosis - a phase IV clinical study of FDA data


Epidermal necrosis is found among people who take Percocet, especially for people who are female, 60+ old.

The phase IV clinical study analyzes which people take Percocet and have Epidermal necrosis. It is created by eHealthMe based on reports of 93,149 people who have side effects when taking Percocet from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On May, 26, 2023

93,149 people reported to have side effects when taking Percocet.
Among them, 9 people (0.01%) have Epidermal necrosis.

What is Percocet?

Percocet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 96,769 Percocet users for its effectiveness, alternative drugs and more.

What is Epidermal necrosis?

Epidermal necrosis (skin condition that is usually caused by a reaction to drugs) is found to be associated with 461 drugs and 306 conditions by eHealthMe.

Number of Percocet and Epidermal necrosis reports submitted per year:

Could Percocet cause Epidermal necrosis?

Gender of people who have Epidermal necrosis when taking Percocet *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Epidermal necrosis when taking Percocet *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 100 %

Common drugs people take besides Percocet *:

  1. Zovirax: 9 people, 100.00%
  2. Rituxan: 9 people, 100.00%
  3. Hydroxyzine: 9 people, 100.00%
  4. Lasix: 9 people, 100.00%
  5. Lyrica: 9 people, 100.00%
  6. Fosamax: 9 people, 100.00%
  7. Zometa: 9 people, 100.00%
  8. Neupogen: 9 people, 100.00%
  9. Elavil: 9 people, 100.00%
  10. Provera: 9 people, 100.00%

Common side effects people have besides Epidermal necrosis *:

  1. Weight Decreased: 9 people, 100.00%
  2. Blood Immunoglobulin M Increased: 9 people, 100.00%
  3. Delirium (wild excitement): 9 people, 100.00%
  4. Bone Disorder: 9 people, 100.00%
  5. Jaw Disorder (jaw disease): 9 people, 100.00%
  6. Itching: 9 people, 100.00%
  7. Bone Swelling: 9 people, 100.00%
  8. Breast Hyperplasia (accumulation of abnormal cells in a breast duct): 9 people, 100.00%
  9. Breathing Difficulty: 9 people, 100.00%
  10. Burkitt Lymphoma (cancer of the lymphatic system): 9 people, 100.00%

Common conditions people have *:

  1. Multiple Myeloma (cancer of the plasma cells): 9 people, 100.00%
  2. Immunodeficiency Disorders: 9 people, 100.00%
  3. Aseptic Necrosis (the death of bone tissue due to a lack of blood supply): 9 people, 100.00%
  4. Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 1 person, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Percocet and have Epidermal necrosis?

Check whether Epidermal necrosis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Epidermal necrosis and when was it recovered:

Expand to all the drugs that have ingredients of acetaminophen; oxycodone hydrochloride:

Alternative drugs to, pros and cons of Percocet:

Common Percocet side effects:

Browse all side effects of Percocet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Epidermal necrosis treatments and more:

COVID vaccines that are related to Epidermal necrosis:

Common drugs associated with Epidermal necrosis:

All the drugs that are associated with Epidermal necrosis:

All the conditions that are associated with Epidermal necrosis:

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; oxycodone hydrochloride (the active ingredients of Percocet) and Percocet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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