Percocet and Pneumocephalus - a phase IV clinical study of FDA data


Pneumocephalus is found among people who take Percocet, especially for people who are male, 40-49 old.

The phase IV clinical study analyzes which people take Percocet and have Pneumocephalus. It is created by eHealthMe based on reports of 93,149 people who have side effects when taking Percocet from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 03, 2022

93,149 people reported to have side effects when taking Percocet.
Among them, 6 people (0.01%) have Pneumocephalus.

What is Percocet?

Percocet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 96,749 Percocet users for its effectiveness, alternative drugs and more.

What is Pneumocephalus?

Pneumocephalus (presence of air or gas within the cranial cavity) is found to be associated with 189 drugs and 101 conditions by eHealthMe.

Number of Percocet and Pneumocephalus reports submitted per year:

Could Percocet cause Pneumocephalus?

Gender of people who have Pneumocephalus when taking Percocet *:

  • female: 33.33 %
  • male: 66.67 %

Age of people who have Pneumocephalus when taking Percocet *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 40 %
  • 40-49: 60 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

Common drugs people take besides Percocet *:

  1. Neurontin: 4 people, 66.67%
  2. Thorazine: 4 people, 66.67%
  3. Ambien: 4 people, 66.67%
  4. Seroquel: 4 people, 66.67%
  5. Paxil: 4 people, 66.67%
  6. Trileptal: 4 people, 66.67%
  7. Lamictal: 4 people, 66.67%
  8. Carisoprodol: 2 people, 33.33%
  9. Fioricet: 2 people, 33.33%
  10. Folic Acid: 1 person, 16.67%

Common side effects people have besides Pneumocephalus *:

  1. Confusional State: 5 people, 83.33%
  2. Abnormal Behavior: 4 people, 66.67%
  3. Pleural Effusion (water on the lungs): 4 people, 66.67%
  4. Facial Bones Fracture (bone fracture of face): 4 people, 66.67%
  5. Hypocalcaemia (levels of calcium in blood serum are abnormally low): 4 people, 66.67%
  6. Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 4 people, 66.67%
  7. Indigestion: 4 people, 66.67%
  8. Drug Ineffective: 4 people, 66.67%
  9. Diabetes Insipidus (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function): 4 people, 66.67%
  10. Delirium (wild excitement): 4 people, 66.67%

Common conditions people have *:

  1. Depression: 3 people, 50.00%
  2. Stress And Anxiety: 1 person, 16.67%
  3. Ill-Defined Disorder: 1 person, 16.67%
  4. Bipolar Disorder (mood disorder): 1 person, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Percocet and have Pneumocephalus?

Check whether Pneumocephalus is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Pneumocephalus and when was it recovered:

Expand to all the drugs that have ingredients of acetaminophen; oxycodone hydrochloride:

Alternative drugs to, pros and cons of Percocet:

Common Percocet side effects:

Browse all side effects of Percocet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Pneumocephalus treatments and more:

COVID vaccines that are related to Pneumocephalus:

All the drugs that are associated with Pneumocephalus:

All the conditions that are associated with Pneumocephalus:

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; oxycodone hydrochloride (the active ingredients of Percocet) and Percocet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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