Phentermine and Crohn's disease - a phase IV clinical study of FDA data


Crohn's disease is found among people who take Phentermine, especially for people who are female, 20-29 old, have been taking the drug for 1 - 2 years.

The phase IV clinical study analyzes which people take Phentermine and have Crohn's disease. It is created by eHealthMe based on reports of 14,395 people who have side effects when taking Phentermine from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Jan, 30, 2023

14,395 people reported to have side effects when taking Phentermine.
Among them, 11 people (0.08%) have Crohn's disease.

What is Phentermine?

Phentermine has active ingredients of phentermine hydrochloride. It is often used in weight loss. eHealthMe is studying from 18,485 Phentermine users for its effectiveness, alternative drugs and more.

What is Crohn's disease?

Crohn's disease (condition that causes inflammation of the gastrointestinal tract) is found to be associated with 2,441 drugs and 1,929 conditions by eHealthMe.

Number of Phentermine and Crohn's disease reports submitted per year:

Could Phentermine cause Crohn's disease?

Time on Phentermine when people have Crohn's disease *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 100 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Crohn's disease when taking Phentermine *:

  • female: 81.82 %
  • male: 18.18 %

Age of people who have Crohn's disease when taking Phentermine *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 14.29 %
  • 20-29: 42.86 %
  • 30-39: 14.29 %
  • 40-49: 14.29 %
  • 50-59: 14.29 %
  • 60+: 0.0 %

Common drugs people take besides Phentermine *:

  1. Accutane: 3 people, 27.27%
  2. Humira: 3 people, 27.27%
  3. Wellbutrin: 2 people, 18.18%
  4. Vitamin D2: 2 people, 18.18%
  5. Cimzia: 2 people, 18.18%
  6. Effexor: 1 person, 9.09%
  7. Magnesium: 1 person, 9.09%
  8. Imuran: 1 person, 9.09%
  9. Imodium: 1 person, 9.09%
  10. Imitrex: 1 person, 9.09%

Common side effects people have besides Crohn's disease *:

  1. Hot Flush (sudden feelings of heat): 3 people, 27.27%
  2. Inflammatory Bowel Disease: 3 people, 27.27%
  3. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 27.27%
  4. Intestinal Obstruction: 2 people, 18.18%
  5. Fatigue (feeling of tiredness): 2 people, 18.18%
  6. Dry Skin: 2 people, 18.18%
  7. Hypoaesthesia (reduced sense of touch or sensation): 2 people, 18.18%
  8. Nosebleed (bleeding from nose): 2 people, 18.18%
  9. Depression: 2 people, 18.18%
  10. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 18.18%

Common conditions people have *:

  1. Depression: 4 people, 36.36%
  2. Weight Decreased: 2 people, 18.18%
  3. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 18.18%
  4. High Blood Pressure: 2 people, 18.18%
  5. Migraine (headache): 2 people, 18.18%
  6. Acne (skin problems that cause pimples): 2 people, 18.18%
  7. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 18.18%
  8. Renal Disorder (kidney disease): 1 person, 9.09%
  9. Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 1 person, 9.09%
  10. Acne Cystic (skin problems that cause pimples): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Phentermine and have Crohn's disease?

Check whether Crohn's disease is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Crohn's disease and when was it recovered:

Expand to all the drugs that have ingredients of phentermine hydrochloride:

Alternative drugs to, pros and cons of Phentermine:

Common Phentermine side effects:

Browse all side effects of Phentermine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Crohn's disease treatments and more:

COVID vaccines that are related to Crohn's disease:

Common drugs associated with Crohn's disease:

All the drugs that are associated with Crohn's disease:

Common conditions associated with Crohn's disease:

All the conditions that are associated with Crohn's disease:

How the study uses the data?

The study uses data from the FDA. It is based on phentermine hydrochloride (the active ingredients of Phentermine) and Phentermine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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