Plaquenil and Migraine with aura - a phase IV clinical study of FDA data


We study 85,611 people who have side effects when taking Plaquenil. Migraine with aura is found, especially among people who are female, 60+ old, also take Fosamax and have Osteoporosis.

The phase IV clinical study analyzes which people take Plaquenil and have Migraine with aura. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

What are phase IV trials?

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 24, 2023

85,611 people reported to have side effects when taking Plaquenil.
Among them, 19 people (0.02%) have Migraine with aura.

What is Plaquenil?

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is used in systemic lupus erythematosus. Currently, eHealthMe is studying from 88,236 Plaquenil users.

What is Migraine with aura?

Migraine with aura (headache with vision weakness) is found to be associated with 1,191 drugs and 814 conditions by eHealthMe. Currently, we are studying 5,678 people who have Migraine with aura.

Number of Plaquenil and Migraine with aura reports submitted per year:

Could Plaquenil cause Migraine with aura?

Gender of people who have Migraine with aura when taking Plaquenil *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Migraine with aura when taking Plaquenil *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 6.67 %
  • 40-49: 26.67 %
  • 50-59: 13.33 %
  • 60+: 53.33 %

Common drugs people take besides Plaquenil *:

  1. Fosamax: 8 people, 42.11%
  2. Vitamin D: 6 people, 31.58%
  3. Humira: 6 people, 31.58%
  4. Daypro: 4 people, 21.05%
  5. Prolia: 4 people, 21.05%
  6. Lutein: 4 people, 21.05%
  7. Xanax: 4 people, 21.05%
  8. Hydroxychloroquine Sulfate: 4 people, 21.05%
  9. Didronel: 4 people, 21.05%
  10. Coenzyme Q10: 3 people, 15.79%

Common side effects people have besides Migraine with aura *:

  1. Fatigue (feeling of tiredness): 12 people, 63.16%
  2. Pain In Extremity: 9 people, 47.37%
  3. Weight Increased: 8 people, 42.11%
  4. Nausea (feeling of having an urge to vomit): 8 people, 42.11%
  5. Essential Hypertension (primary hypertension): 7 people, 36.84%
  6. Stress And Anxiety: 7 people, 36.84%
  7. Migraine (headache): 6 people, 31.58%
  8. Joint Pain: 6 people, 31.58%
  9. Influenza Like Illness: 6 people, 31.58%
  10. Headache (pain in head): 6 people, 31.58%

Common conditions people have *:

  1. Osteoporosis (bones weak and more likely to break): 8 people, 42.11%
  2. Polyarthritis (arthritis which involves 5 or more joints simultaneously): 4 people, 21.05%
  3. Insomnia (sleeplessness): 3 people, 15.79%
  4. Menopause (end of monthly cycles in women): 2 people, 10.53%
  5. Muscle Spasms (muscle contraction): 2 people, 10.53%
  6. Bladder Spasm: 2 people, 10.53%
  7. Cough: 2 people, 10.53%
  8. Gastrointestinal Disorder (functional problems of gastrointestinal tract): 2 people, 10.53%
  9. Gilles De La Tourette Syndrome (a condition that causes people to make repeated, quick movements or sounds that they cannot control): 2 people, 10.53%
  10. High Blood Pressure: 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

Do you take Plaquenil and have Migraine with aura?

Check whether Migraine with aura is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Migraine with aura and when was it recovered:

Expand to all the drugs that have ingredients of hydroxychloroquine sulfate:

Alternative drugs to, pros and cons of Plaquenil:

Browse all side effects of Plaquenil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Migraine with aura treatments and more:

Common drugs associated with Migraine with aura:

All the drugs that are associated with Migraine with aura:

Common conditions associated with Migraine with aura:

All the conditions that are associated with Migraine with aura:

How the study uses the data?

The study uses data from the FDA. It is based on hydroxychloroquine sulfate (the active ingredients of Plaquenil) and Plaquenil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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