Plaquenil and Pityriasis rubra pilaris - a phase IV clinical study of FDA data


Pityriasis rubra pilaris is reported only by a few people who take Plaquenil.

The phase IV clinical study analyzes which people take Plaquenil and have Pityriasis rubra pilaris. It is created by eHealthMe based on reports of 80,685 people who have side effects while taking Plaquenil from the FDA, and is updated regularly.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 05, 2023

80,685 people reported to have side effects when taking Plaquenil.
Among them, 2 people (0.0%) have Pityriasis rubra pilaris.

What is Plaquenil?

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. eHealthMe is studying from 83,248 Plaquenil users for its effectiveness, alternative drugs and more.

What is Pityriasis rubra pilaris?

Pityriasis rubra pilaris (reddish-orange colour scaling patches with well defined borders) is found to be associated with 114 drugs and 49 conditions by eHealthMe.

Number of Plaquenil and Pityriasis rubra pilaris reports submitted per year:

Could Plaquenil cause Pityriasis rubra pilaris?

Time on Plaquenil when people have Pityriasis rubra pilaris *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Pityriasis rubra pilaris when taking Plaquenil *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Pityriasis rubra pilaris when taking Plaquenil *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 100 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

Common drugs people take besides Plaquenil *:

  1. Zyrtec: 2 people, 100.00%
  2. Voriconazole: 2 people, 100.00%
  3. Vfend: 2 people, 100.00%
  4. Valtrex: 2 people, 100.00%
  5. Remeron: 2 people, 100.00%
  6. Nplate: 2 people, 100.00%
  7. Neupogen: 2 people, 100.00%
  8. Levaquin: 2 people, 100.00%
  9. Folic Acid: 2 people, 100.00%
  10. Daptomycin: 2 people, 100.00%

Common side effects people have besides Pityriasis rubra pilaris *:

  1. Viraemia (presence of a virus in the blood stream): 2 people, 100.00%
  2. Thrombocytopenia (decrease of platelets in blood): 2 people, 100.00%
  3. Adverse Drug Reaction: 2 people, 100.00%
  4. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 2 people, 100.00%
  5. Blood Pressure Fluctuation: 2 people, 100.00%
  6. Blood Product Transfusion Dependent: 2 people, 100.00%
  7. Cough: 2 people, 100.00%
  8. Depression: 2 people, 100.00%
  9. Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 2 people, 100.00%
  10. Drug Ineffective: 2 people, 100.00%

Common conditions people have *:

  1. Thrombocytopenia (decrease of platelets in blood): 2 people, 100.00%
  2. Itching: 2 people, 100.00%
  3. Dry Eyes (lack of adequate tears): 2 people, 100.00%

* Approximation only. Some reports may have incomplete information.

Do you take Plaquenil and have Pityriasis rubra pilaris?

Check whether Pityriasis rubra pilaris is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Pityriasis rubra pilaris and when was it recovered:

Expand to all the drugs that have ingredients of hydroxychloroquine sulfate:

Alternative drugs to, pros and cons of Plaquenil:

Common Plaquenil side effects:

Browse all side effects of Plaquenil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Pityriasis rubra pilaris treatments and more:

COVID vaccines that are related to Pityriasis rubra pilaris:

All the drugs that are associated with Pityriasis rubra pilaris:

All the conditions that are associated with Pityriasis rubra pilaris:

How the study uses the data?

The study uses data from the FDA. It is based on hydroxychloroquine sulfate (the active ingredients of Plaquenil) and Plaquenil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe: