Prednisolone and Serotonin syndrome - a phase IV clinical study of FDA data

Summary:

Serotonin syndrome is found among people who take Prednisolone, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months.

The phase IV clinical study analyzes which people take Prednisolone and have Serotonin syndrome. It is created by eHealthMe based on reports of 180,802 people who have side effects when taking Prednisolone from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Mar, 27, 2023

180,802 people reported to have side effects when taking Prednisolone.
Among them, 83 people (0.05%) have Serotonin syndrome.

What is Prednisolone?

Prednisolone has active ingredients of prednisolone. It is often used in rheumatoid arthritis. eHealthMe is studying from 182,055 Prednisolone users for its effectiveness, alternative drugs and more.

What is Serotonin syndrome?

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) is found to be associated with 1,580 drugs and 1,123 conditions by eHealthMe.

Number of Prednisolone and Serotonin syndrome reports submitted per year:

Could Prednisolone cause Serotonin syndrome?

Time on Prednisolone when people have Serotonin syndrome *:

Gender of people who have Serotonin syndrome when taking Prednisolone *:

female: 53.25 %
male: 46.75 %

Age of people who have Serotonin syndrome when taking Prednisolone *:

Common drugs people take besides Prednisolone *:

Common side effects people have besides Serotonin syndrome *:

Confusional State: 14 people, 16.87%
Hyperhidrosis (abnormally increased sweating): 11 people, 13.25%
Agitation (state of anxiety or nervous excitement): 10 people, 12.05%
Inappropriate Antidiuretic Hormone Secretion: 9 people, 10.84%
Nausea And Vomiting: 8 people, 9.64%
Body Temperature Increased: 8 people, 9.64%
Arrhythmias (irregular heartbeat): 8 people, 9.64%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 8 people, 9.64%
High Blood Pressure: 7 people, 8.43%
Eye Movements - Uncontrollable: 7 people, 8.43%

Common conditions people have *:

Depression: 28 people, 33.73%
Pain: 25 people, 30.12%
Neuralgia (pain in one or more nerves): 13 people, 15.66%
Pneumonia Staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus): 8 people, 9.64%
Stress And Anxiety: 5 people, 6.02%
Diabetes: 4 people, 4.82%
Weight Loss: 4 people, 4.82%
Sedation: 3 people, 3.61%
Sleep Disorder: 3 people, 3.61%
Enterococcal Infection: 3 people, 3.61%

* Approximation only. Some reports may have incomplete information.

Do you take Prednisolone and have Serotonin syndrome?

Check whether Serotonin syndrome is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Abdullah, D., Mohamed, A. M. F. S., & Liew, A. K. C., "Dentine hypersensitivity-like tooth pain associated with the use of high-dose steroid therapy", Journal of conservative dentistry: JCD, 2018 Jan .
Behnoush B, Memarian A, Teimoory M, "Naltrexone Induced Serotonin Syndrome", International Journal of Medical Toxicology and Forensic Medicine, 2013 Apr .

Related studies

How severe was Serotonin syndrome and when was it recovered:

Serotonin syndrome in Prednisolone

Expand to all the drugs that have ingredients of prednisolone:

Serotonin syndrome and drugs with ingredients of prednisolone (54 reports)

Alternative drugs to, pros and cons of Prednisolone:

Prednisolone (182,055 reports)

Common Prednisolone side effects:

Fever: 10,764 reports
Pneumonia: 9,340 reports
Drug ineffective: 8,974 reports
Diarrhea: 7,028 reports
Breathing difficulty: 7,011 reports
Rashes (redness): 6,528 reports
Thrombocytopenia (decrease of platelets in blood): 6,390 reports

Browse all side effects of Prednisolone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Serotonin syndrome treatments and more:

Serotonin syndrome (17,788 reports)

COVID vaccines that are related to Serotonin syndrome:

Common drugs associated with Serotonin syndrome:

All the drugs that are associated with Serotonin syndrome:

Serotonin syndrome (1,580 drugs)

Common conditions associated with Serotonin syndrome:

Depression: 4,717 reports
Pain: 1,295 reports
Stress and anxiety: 948 reports
Major depression: 608 reports
Insomnia: 560 reports

All the conditions that are associated with Serotonin syndrome:

Serotonin syndrome (1,123 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on prednisolone (the active ingredients of Prednisolone) and Prednisolone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.