Premarin and Lichen planus - a phase IV clinical study of FDA data


Lichen planus is found among people who take Premarin, especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years.

The phase IV clinical study analyzes which people take Premarin and have Lichen planus. It is created by eHealthMe based on reports of 94,499 people who have side effects when taking Premarin from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 01, 2022

94,499 people reported to have side effects when taking Premarin.
Among them, 37 people (0.04%) have Lichen planus.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 95,572 Premarin users for its effectiveness, alternative drugs and more.

What is Lichen planus?

Lichen planus (an inflammatory skin condition, characterized by an itchy, non-infectious rash) is found to be associated with 836 drugs and 516 conditions by eHealthMe.

Number of Premarin and Lichen planus reports submitted per year:

Could Premarin cause Lichen planus?

Time on Premarin when people have Lichen planus *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 50 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 50 %
  • 10+ years: 0.0 %

Gender of people who have Lichen planus when taking Premarin *:

  • female: 100 %
  • male: 0.0 %

Age of people who have Lichen planus when taking Premarin *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 2.94 %
  • 50-59: 26.47 %
  • 60+: 70.59 %

Common drugs people take besides Premarin *:

  1. Synthroid: 18 people, 48.65%
  2. Fosamax: 16 people, 43.24%
  3. Atenolol: 9 people, 24.32%
  4. Actonel: 7 people, 18.92%
  5. Calcium: 6 people, 16.22%
  6. Codeine: 5 people, 13.51%
  7. Prolia: 5 people, 13.51%
  8. Aspirin: 4 people, 10.81%
  9. Vioxx: 4 people, 10.81%
  10. Cytomel: 3 people, 8.11%

Common side effects people have besides Lichen planus *:

  1. Oedema Peripheral (superficial swelling): 20 people, 54.05%
  2. Cellulitis (infection under the skin): 19 people, 51.35%
  3. Sinusitis (inflammation of sinus): 16 people, 43.24%
  4. Dental Caries: 16 people, 43.24%
  5. Oral Torus (a lesion made of compact bone and occurs along the palate or the mandible inside the mouth): 15 people, 40.54%
  6. Arthropathy: 15 people, 40.54%
  7. Tooth Abscess (pus formation in tooth): 15 people, 40.54%
  8. Stress And Anxiety: 15 people, 40.54%
  9. Fall: 15 people, 40.54%
  10. Joint Pain: 14 people, 37.84%

Common conditions people have *:

  1. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 11 people, 29.73%
  2. Senile Osteoporosis (weak bones with ageing): 9 people, 24.32%
  3. Heart Rate Irregular: 9 people, 24.32%
  4. Osteopenia (a condition where bone mineral density is lower than normal): 7 people, 18.92%
  5. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 13.51%
  6. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 13.51%
  7. High Blood Pressure: 4 people, 10.81%
  8. Joint Pain: 3 people, 8.11%
  9. Osteoporosis (bones weak and more likely to break): 2 people, 5.41%
  10. Macular Degeneration (painless eye condition that leads to the gradual loss of central vision): 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

Do you take Premarin and have Lichen planus?

Check whether Lichen planus is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Lichen planus and when was it recovered:

Expand to all the drugs that have ingredients of estrogens, conjugated:

Alternative drugs to, pros and cons of Premarin:

Common Premarin side effects:

Browse all side effects of Premarin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Lichen planus treatments and more:

COVID vaccines that are related to Lichen planus:

Common drugs associated with Lichen planus:

All the drugs that are associated with Lichen planus:

Common conditions associated with Lichen planus:

All the conditions that are associated with Lichen planus:

How the study uses the data?

The study uses data from the FDA. It is based on estrogens, conjugated (the active ingredients of Premarin) and Premarin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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