Premarin and Tinnitus - from FDA reports

Tinnitus is found among people who take Premarin, especially for people who are female, 60+ old , have been taking the drug for 10+ years, also take medication Synthroid, and have Depression. This study is created by eHealthMe based on reports of 83,146 people who have side effects when taking Premarin from FDA, and is updated regularly.

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On Nov, 13, 2018

83,146 people reported to have side effects when taking Premarin.
Among them, 420 people (0.51%) have Tinnitus

Number of reports submitted per year:

Could Premarin cause Tinnitus?

Time on Premarin when people have Tinnitus *:

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 8.7 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 30.43 %
  • 10+ years: 60.87 %

Gender of people who have Tinnitus when taking Premarin *:

  • female: 98.77 %
  • male: 1.23 %

Age of people who have Tinnitus when taking Premarin *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.29 %
  • 20-29: 0.58 %
  • 30-39: 2.92 %
  • 40-49: 12.24 %
  • 50-59: 38.19 %
  • 60+: 45.77 %

Top conditions involved for these people *:

  1. Depression: 42 people, 10.00%
  2. Osteoporosis (bones weak and more likely to break): 35 people, 8.33%
  3. Osteopenia (a condition where bone mineral density is lower than normal): 20 people, 4.76%
  4. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 18 people, 4.29%
  5. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 17 people, 4.05%

Click here to view more results or personalize the results to your gender and age

Top co-used drugs for these people *:

  1. Synthroid: 83 people, 19.76%
  2. Vioxx: 74 people, 17.62%
  3. Fosamax: 74 people, 17.62%
  4. Lipitor: 62 people, 14.76%
  5. Celebrex: 59 people, 14.05%

Click here to view more results or personalize the results to your gender and age

Top other side effects for these people *:

  1. Dizziness: 130 people, 30.95%
  2. Headache (pain in head): 116 people, 27.62%
  3. Pain: 102 people, 24.29%
  4. Fall: 98 people, 23.33%
  5. Fatigue (feeling of tiredness): 98 people, 23.33%

Click here to view more results or personalize the results to your gender and age

* Approximation only. Some reports may have incomplete information.

FDA reports used in this study

Do you have Tinnitus while taking Premarin?

You are not alone:

Related studies


Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. (latest outcomes from Premarin 84,099 users)


Tinnitus (a ringing in the ears) has been reported by people with depression, high blood pressure, pain, high blood cholesterol, stress and anxiety (latest reports from 36,038 Tinnitus patients).

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What would happen?

Predict new side effects and undetected conditions when you take Premarin and have Tinnitus

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NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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