Probiotic and Rhabdomyolysis - a phase IV clinical study of FDA data


Rhabdomyolysis is found among people who take Probiotic, especially for people who are male, 60+ old, have been taking the drug for < 1 month.

The phase IV clinical study analyzes which people take Probiotic and have Rhabdomyolysis. It is created by eHealthMe based on reports of 20,702 people who have side effects when taking Probiotic from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Oct, 03, 2022

20,702 people reported to have side effects when taking Probiotic.
Among them, 14 people (0.07%) have Rhabdomyolysis.

What is Probiotic?

Probiotic has active ingredients of bacillus coagulans. It is often used in irritable bowel syndrome. eHealthMe is studying from 21,341 Probiotic users for its effectiveness, alternative drugs and more.

What is Rhabdomyolysis?

Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down) is found to be associated with 2,286 drugs and 1,852 conditions by eHealthMe.

Number of Probiotic and Rhabdomyolysis reports submitted per year:

Could Probiotic cause Rhabdomyolysis?

Time on Probiotic when people have Rhabdomyolysis *:

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

Gender of people who have Rhabdomyolysis when taking Probiotic *:

  • female: 45.45 %
  • male: 54.55 %

Age of people who have Rhabdomyolysis when taking Probiotic *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 22.22 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 22.22 %
  • 60+: 55.56 %

Common drugs people take besides Probiotic *:

  1. Magnesium: 4 people, 28.57%
  2. Vitamin D: 4 people, 28.57%
  3. Multivitamin: 3 people, 21.43%
  4. Lipitor: 3 people, 21.43%
  5. Vitamin C: 3 people, 21.43%
  6. Fish Oil: 3 people, 21.43%
  7. Coenzyme Q10: 3 people, 21.43%
  8. Crestor: 3 people, 21.43%
  9. Tirosint: 2 people, 14.29%
  10. Norvasc: 2 people, 14.29%

Common side effects people have besides Rhabdomyolysis *:

  1. Pneumonia: 4 people, 28.57%
  2. Fatigue (feeling of tiredness): 3 people, 21.43%
  3. Sepsis (a severe blood infection that can lead to organ failure and death): 3 people, 21.43%
  4. Muscle Aches (muscle pain): 3 people, 21.43%
  5. Weakness: 2 people, 14.29%
  6. Non-Alcoholic Steatohepatitis (liver inflammation caused by a build up of fat in the liver): 2 people, 14.29%
  7. Fever: 2 people, 14.29%
  8. Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 2 people, 14.29%
  9. Dizziness: 2 people, 14.29%
  10. Irritability: 2 people, 14.29%

Common conditions people have *:

  1. High Density Lipoprotein Increased: 2 people, 14.29%
  2. Low Density Lipoprotein Decreased (cholesterol decreased): 2 people, 14.29%
  3. Cushing's Syndrome (obesity, a rounded face, increased fat): 2 people, 14.29%
  4. Acne (skin problems that cause pimples): 2 people, 14.29%
  5. Oedema (fluid collection in tissue): 1 person, 7.14%
  6. Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 1 person, 7.14%
  7. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 7.14%
  8. Bipolar Disorder (mood disorder): 1 person, 7.14%
  9. Post Procedural Infection: 1 person, 7.14%
  10. Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Probiotic and have Rhabdomyolysis?

Check whether Rhabdomyolysis is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related publications that referenced our studies

Related studies

How severe was Rhabdomyolysis and when was it recovered:

Expand to all the drugs that have ingredients of bacillus coagulans:

Alternative drugs to, pros and cons of Probiotic:

Common Probiotic side effects:

Browse all side effects of Probiotic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Rhabdomyolysis treatments and more:

COVID vaccines that are related to Rhabdomyolysis:

Common drugs associated with Rhabdomyolysis:

All the drugs that are associated with Rhabdomyolysis:

Common conditions associated with Rhabdomyolysis:

All the conditions that are associated with Rhabdomyolysis:

How the study uses the data?

The study uses data from the FDA. It is based on bacillus coagulans (the active ingredients of Probiotic) and Probiotic (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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