Prolia and Retinal haemorrhage - a phase IV clinical study of FDA data


Retinal haemorrhage is found among people who take Prolia, especially for people who are female, 60+ old.

The phase IV clinical study analyzes which people take Prolia and have Retinal haemorrhage. It is created by eHealthMe based on reports of 137,760 people who have side effects when taking Prolia from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Feb, 03, 2023

137,760 people reported to have side effects when taking Prolia.
Among them, 8 people (0.01%) have Retinal haemorrhage.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 138,290 Prolia users for its effectiveness, alternative drugs and more.

What is Retinal haemorrhage?

Retinal haemorrhage (bleeding from retina) is found to be associated with 1,219 drugs and 729 conditions by eHealthMe.

Number of Prolia and Retinal haemorrhage reports submitted per year:

Could Prolia cause Retinal haemorrhage?

Gender of people who have Retinal haemorrhage when taking Prolia *:

  • female: 87.5 %
  • male: 12.5 %

Age of people who have Retinal haemorrhage when taking Prolia *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 14.29 %
  • 50-59: 0.0 %
  • 60+: 85.71 %

Common drugs people take besides Prolia *:

  1. Solu-Medrol: 3 people, 37.50%
  2. Aleve: 2 people, 25.00%
  3. Ampyra: 2 people, 25.00%
  4. Synthroid: 2 people, 25.00%
  5. Betaseron: 2 people, 25.00%
  6. Calcium: 2 people, 25.00%
  7. Omeprazole: 2 people, 25.00%
  8. Vitamin D: 2 people, 25.00%
  9. Magnesium: 2 people, 25.00%
  10. Lisinopril: 1 person, 12.50%

Common side effects people have besides Retinal haemorrhage *:

  1. Breast Cancer: 3 people, 37.50%
  2. Gait Disturbance: 3 people, 37.50%
  3. Peripheral Swelling: 2 people, 25.00%
  4. Therapeutic Response Unexpected: 2 people, 25.00%
  5. Cataract (clouding of the lens inside the eye): 2 people, 25.00%
  6. Colon Cancer: 2 people, 25.00%
  7. Dizziness: 2 people, 25.00%
  8. Nosebleed (bleeding from nose): 2 people, 25.00%
  9. Exposure To Toxic Agent: 2 people, 25.00%
  10. Visual Impairment: 1 person, 12.50%

Common conditions people have *:

  1. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 25.00%
  2. Gait Disturbance: 2 people, 25.00%
  3. Dizziness: 2 people, 25.00%
  4. Colon Cancer: 2 people, 25.00%
  5. Back Pain: 2 people, 25.00%
  6. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 12.50%
  7. Reflux Gastritis (a condition in which the lining of a person's stomach becomes inflamed as a result of exposure to bile): 1 person, 12.50%
  8. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 12.50%
  9. Psoriasis (immune-mediated disease that affects the skin): 1 person, 12.50%
  10. Migraine (headache): 1 person, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Prolia and have Retinal haemorrhage?

Check whether Retinal haemorrhage is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

How severe was Retinal haemorrhage and when was it recovered:

Expand to all the drugs that have ingredients of denosumab:

Alternative drugs to, pros and cons of Prolia:

Common Prolia side effects:

Browse all side effects of Prolia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Retinal haemorrhage treatments and more:

COVID vaccines that are related to Retinal haemorrhage:

Common drugs associated with Retinal haemorrhage:

All the drugs that are associated with Retinal haemorrhage:

Common conditions associated with Retinal haemorrhage:

All the conditions that are associated with Retinal haemorrhage:

How the study uses the data?

The study uses data from the FDA. It is based on denosumab (the active ingredients of Prolia) and Prolia (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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